Valarmathi Thiruvanamalai

Assistant Professor This email address is being protected from spambots. You need JavaScript enabled to view it.
Volker G094S
(205) 996-1280

Research and Teaching Interests: Stem Cell Biology, Stem Cell Genome Engineering, Functional Tissue Engineering, Regenerative Medicine

Office Hours: By appointment

Education:

  • B.Sc., Chemistry, University of Madras (Dwaraka Doss Goverdhan Doss Vaishnav College), Madras, India
  • M.B.B.S., Medicine & Surgery, University of Madras (Kilpauk Medical College), Madras, India
  • M.D., Pathology, University of Madras (Postgraduate Institute of Basic Medical Sciences), Madras, India
  • Ph.D., Biotechnology, All-India Institute of Medical Sciences (AIIMS), New Delhi, India
  • Postdoctoral Fellowship Training, Embryonic Stem Cells, Laboratory of Molecular Biology (LMB), Centre for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA – Dr. Ira Pastan
  • Pedagogy Course, Scientists Teaching Science Online Course, The New York Academy of Sciences, Science Alliance, New York, New York, USA

Stem Cell Courses and Trainings:

  • LifeLab™ Pluripotent Stem Cell Workshop, LifeLab™ Stem Cell Research Centers, Life Technologies, Carlsbad, California, USA
  • Regenerative Medicine Essentials Course: The Fundamentals to the Future Wake Forest Institute for Regenerative Medicine (WFIRM), Winston-Salem, North Carolina, USA
  • Frontiers in Human Embryonic Stem Cells Advance Training Course – FrHESC, Marine Biological Laboratory (MBL), Woods Hole, Massachusetts, USA
  • Short-Term Course in Human Embryonic Stem Cell Culture Techniques – hESC, Johns Hopkins University (JHU), Baltimore, Maryland, USA

Dr. Valarmathi M. Thiruvanamalai received his B.Sc. in Chemistry, M.B.B.S. in Medicine & Surgery and M.D. in Pathology from the University of Madras, Madras, India; as well as Ph.D. in Medical Biotechnology from All-India Institute of Medical Sciences (AIIMS), New Delhi, India. He was appointed as an Assistant Professor in the Department of Pathology in SRMC & RI (Deemed University), affiliated to Harvard Medical International, Madras, India. He received a Visiting Scientist Fellowship from the National Institute of Health (NIH) and spent two years with Dr. Ira Pastan in the Laboratory of Molecular Biology (LMB). He joined the Department of Comparative Biosciences at the University of Illinois at Urbana-Champaign (UIUC) in 2013 after working as a Research Assistant Professor at the University of South Carolina (USC), Columbia, South Carolina. In UIUC, he conducted his cardiovascular physiology teaching and cardiovascular research in College of Medicine, College of Veterinary Medicine, and the Beckman Institute for Advanced Science and Technology. His past research experience includes human cancer genetics. He is serving as a member in various prestigious national and international scientific societies and organizations such as ISSCR, TERMIS, AACR, ASIP, ACS, ESC, ISHR, ASGCT, and AHA. Currently, his research mainly focuses on creating functional vascularized tissue-engineered constructs for cardiovascular repair and regeneration.

pdfDownload CV

Research Interests

The long term goal of our research laboratory is to work on thrust areas like:

  • Creating 3D vascularized tissues and/or organs for regenerative medicine using autologous and/or allogeneic stem cells, induced pluripotent stem cells (iPSCs) and/or multipotent adult stem cells (MSCs), e.g., “3D functional vascularized cardiac tissue constructs” for repair and regeneration purposes by applying engineering principles (translational aspect).
  • Using the same 3D models of tissues for the study of basic biological molecular mechanisms, e.g., creating in vitro “3D models of cardiomyogenesis & cardiovascular diseases” to study various aspects of normal and pathological tissue developments by employing developmental and genetic engineering approaches, including CRISPR/Cas systems, the powerful genome editing tool (mechanistic aspect).
  • As well as, for the use of drug discovery and toxicity screening, e.g., “cardiotoxicity” (therapeutic aspect).

In a nutshell, our research is state-of-the-art that promises to lead to the generation of total replacement biologic products for various therapeutic purposes in regenerative and/or personalized medicine.

Select Publications

See Valarmathi Thiruvanamalai's PubMed page.

  • Valarmathi MT, Fuseler JW, Potts JD, Davis JM, Price RL. Functional tissue-engineering: A prevascularized cardiac muscle construct for validating human mesenchymal stem cells engraftment potential in vitro. Tissue Eng Part A. 2017 1-29.
  • Valarmathi MT, Fuseler JW, Davis JM, Price RL. A novel human tissue-engineered 3-D functional vascularized cardiac muscle construct. Front Cell Dev Biol. 2017 5:2 1-24.
  • Fuseler JW, Valarmathi MT. Nitric oxide modulates postnatal bone marrow-derived mesenchymal stem cell migration. Front Cell Dev Biol. 2016 4:133 1-20.
  • Fuseler JW, Valarmathi MT. Modulation of the migration and differentiation potential of adult bone marrow stromal stem cells by nitric oxide. Biomaterials 2012 33:1032-43. {2012 The Year in Images}
  • Valarmathi MT, Fuseler JW, Goodwin RL, Davis JM, Potts JD. The mechanical coupling of adult marrow stromal stem cells during cardiac regeneration assessed in a 2-D co-culture model. Biomaterials 2011 32:2834-50.
  • Valarmathi MT, Goodwin RL, Fuseler JW, Davis JM, Yost MJ, Potts JD. A 3-D cardiac muscle construct for exploring adult marrow stem cell based myocardial regeneration. Biomaterials 2010 31:3185-3200.
  • Kaur G, Valarmathi MT, Potts JD, Jabbari E, Sabo-Attwood S, Wang Q. Regulation of osteogenic differentiation of rat bone marrow stromal cells on 2D nanorod substrates. Biomaterials 2010 31:1732-41.
  • Valarmathi MT, Davis JM, Yost MJ, Goodwin RL, Potts JD. A three-dimensional model of vasculogenesis. Biomaterials 2009 30:1098-112.
  • Kaur G, Valarmathi MT, Potts JD, Wang Q. The promotion of osteoblastic differentiation of rat bone marrow stromal cells by a polyvalent plant mosaic virus. Biomaterials 2008 29:4074-81.
  • Valarmathi MT, Yost MJ, Goodwin RL, Potts JD. The influence of proepicardial cells on the osteogenic potential of marrow stromal cells in a three-dimensional tubular scaffold. Biomaterials 2008 29:2203-16. {2008 The Year in Images}
  • Valarmathi MT, Yost MJ, Goodwin RL, Potts JD. A three-dimensional tubular scaffold that modulates the osteogenic and vasculogenic differentiation of rat bone marrow stromal cells. Tissue Eng Part A. 2008 14:491-504. {Journal Cover Article 2008; Journal Cover for Biopreservation and Biobanking 2010}
  • Valarmathi MT, Sawhney M, Deo SS, Shukla NK, Das SN. Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. Hum Mutat. 2004 23:205. (Pages - 1 to 11)
  • Valarmathi MT, Agarwal A, Deo SS, Shukla NK, Das SN. BRCA1 germline mutations in Indian familial breast cancer. Hum Mutat. 2003 21:98-9. (Pages - 1 to 7)

Academic Distinction

  • Research Academy Member - College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign (UIUC), Urbana, Illinois, USA
  • Teacher Ranked as Excellent by Veterinary Medical Students, Veterinary Biosciences, Cardiovascular Physiology Course (VM 603), University of Illinois at Urbana-Champaign (UIUC), Urbana, Illinois, USA
  • Scientist Development Grant Award, American Heart Association (AHA), National Center, Dallas, Texas, USA
  • Nature Reader Panel – Panelist, Nature Publishing Group, Nature Editorial Team, Macmillan, New York, USA
  • Visiting Scientist – Postdoctoral Fellowship, Centre for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA
  • Research Associateship , Indian Council of Medical Research (ICMR), Government of India, New Delhi, INDIA
  • Post M.D./M.S. Training in Medical Biotechnology Fellowship, Department of Biotechnology (DBT), Government of India, New Delhi, INDIA
  • Senior Research Fellowship, Indian Council of Medical Research (ICMR), Government of India, New Delhi, INDIA

Editorial Positions

Editorships

  • Associate Editor, International Journal of Clinical Therapeutics and Diagnosis (IJCTD)
  • Guest Associate Editor, Frontiers in Cell and Developmental Biology – Frontiers Open Access
  • Managing Editor, JBR Journal of Translational Biomarkers and Diagnosis (JBR-TBD)

Editorial Boards

  • Journal of Stem Cell Therapy and Transplantation
  • JSM Bone Marrow Research
  • SciTz Stem Cells Research & Therapy
  • JBR Journal of Translational Diagnostics and Technology (JBR-JTDT)
  • SRL Stem Cell & Research
  • Gene and Cell Therapy
  • Journal of Rheumatology & Muscular System
  • International Journal of Anatomy & Applied Physiology (IJAAP)
  • Studies on Stem Cells Research and Therapy
  • International Journal of Clinical Therapeutics and Diagnosis (IJCTD)
  • Anatomy & Physiology: Current Research
  • Journal of Microbial & Biochemical Technology

Professional Societies

  • American Society of Gene & Cell Therapy – ASGCT
  • International Society for Heart Research - ISHR
  • European Society of Cardiology – ESC
  • Council on Functional Genomics and Translational Biology – AHA FGTB
  • The New York Academy of Sciences – NYAS
  • American Association for the Advancement of Science – AAAS
  • American Chemical Society – ACS
  • Council on Basic Cardiovascular Sciences – AHA BCVS
  • American Association for Cancer Research – AACR
  • American Society for Investigative Pathology – ASIP
  • International Society for Stem Cell Research – ISSCR
  • Tissue Engineering and Regenerative Medicine International Society – TERMIS
  • Dermatopathology Society of India - DSI