Wuqiang Zhu

Assistant Professor This email address is being protected from spambots. You need JavaScript enabled to view it.
Volker G094E
(205) 934-0228

Research and Teaching Interests: Cardiomyocyte cell cycle, Stem/Progenitor cell-mediated myocardial repair, Cardiovascular biomedical engineering

Office Hours: M-F 8:00 a.m.- 5:00 p.m.; and by appointment

Education:

  • M.D., Hubei Medical University, China, Clinical Medicine
  • Ph.D., Tongji Medical College, Huazhong University of Science and Technology, China, Internal Medicine-Cardiology
  • Ph.D., Indiana University, Cellular and Integrative Physiology

I received five years of general cardiology and interventional cardiology training in China, followed by 12 years of cardiovascular research training in the United States. My research is mainly focused on studying the molecular mechanisms of myocardial injury and develop strategies to enhance the efficiency of cell-based myocardial repair.

I completed my Ph.D. thesis in the laboratory of Dr. Loren Field (Indiana University), a world-reknowned scientist in the field of cardiomyocyte cell cycle and stem cells. It was in his laboratory that I studied the regulation of cardiomyocyte cell cycle and therapeutic potential of activation of cardiomyocyte proliferation in the injured heart. In addition, I generated a novel juvenile mouse model to mimic doxorubicin-induced cardiotoxicity in childhood patients. I received my postdoc training in the laboratories of Dr. Gangjian Qin (Northwestern University) and Dr. Jop van Berlo (University of Minnesota). Under their mentorship, I dissected several molecular pathways that regulate the differentiation of c-kit+ cardiac progenitor cells. I also established a novel technique to enhance the homing of c- kit+ progenitor cells to the injured myocardium for repair. My current mentor is Dr. Jianyi Zhang, an internationally recognized scientist in cardiac stem cell field. My ongoing research is to develop strategies to enhance the efficiency of stem cell-based therapy for myocardial injury.

Recent Courses

  • 2017 Guest lecture, Tissue Engineering (BME 435/535, 3 credit hours). Course Director: Dr. Ho-Wook Jun.
  • 2017 Guest lecture, Biological Transport Phenomena (BME 350, 3 credit hours). Course Director: Dr. Palaniappan Sethu.
  • 2017 Guest lecture, Bioelectric Phenomena (BME 461/561, 3 credit hours). Course Director: Andrew Pollard.

Select Publications

  • Wuqiang Zhu*, Meng Zhao* (*Equal contribution), Saidulu Mattapally, Sifeng Chen, Jianyi Zhang. CCND2 Overexpression enhances the regenerative potency of human induced pluripotent stem cell-derived cardiomyocytes. Circulation Research. 2017 (In Press)
  • Karl Toischer*, Wuqiang Zhu* (*Equal contribution), Mark Hunlich, Sean Reuter, Gerd Hasenfuss, Loren J. Field. Cardiomyocyte proliferation enhances survival and cardiac function during chronic pressure overload. Journal of Clinical Investigation. 2017 (In Press)
  • Zhongming Chen*, Wuqiang Zhu* (*Equal contribution), Ingrid Bender, Wuming Gong, Il-Youp Kwak, Amritha Yellamilli, Thomas J. Hodges, Natsumi Nemoto, Jianyi Zhang, Daniel J. Garry, Jop van Berlo. Pathologic stimulus determines lineage commitment of c-kit+ cardiac progenitor cells. Circulation. 2017 (In Press)
  • Wuqiang Zhu, Ling Gao, Jianyi Zhang. Differentiation and transplantation of human induced-pluripotent stem cell derived cardiac cells for myocardial repair. Journal of Visualized Experiments. 2017. (120). doi: 10.3791/55142
  • Wuqiang Zhu, Jianyi Zhang. Meeting Report for the 2017 NIH NHLBI Progenitor Cell Biology Consortium: Cardiovascular Bioengineering Workshop and Symposium. Circulation Research. 2017. 120(11):1709-1712 (Review)
  • Mounica Yanamandala, Wuqiang Zhu, Daniel J. Garry, Timothy J. Kamp, Joshua M. Hare, Ho-wook Jun, Young-sup Yoon, Nenad Bursac, Sumanth Prabhu, Gerald W. Dorn, II Roberto Bolli, Richard N. Kitsis, Jianyi Zhang. Overcoming the roadblocks to cardiac cell therapy using tissue engineering. Journal of the American College of Cardiology. 2017. 70(6):766-775 (Review)

Academic Distinctions and Professional Societies

  • 2016-2019: Enhancing post-infarction myogenesis via transplantation of cyclin D2 expressing iPSC-derived cardiomyocytes. American Heart Association Scientist Development Grant (16SDG30410018). Role: PI
  • 2016-2017: Bioenergetic study of myocardial repair using a bioengineered heart tissue. University of Alabama at Birmingham Center for Clinical and Translational Science (CCTS) Grant. Role: PI