Other

Other

Researchers at UAB have developed a SUMOylation assay that can be used to identify inhibitors of any step of the SUMO conjugation reaction, as well as allosteric changes in both the E1 and E2 enzymes that modulate SUMOylation efficiency, noncovalent SUMO binding, or any protein-protein interactions between E1, E2, SUMO, or peptide.

In vitro assay to assess conjugation of the ubiquitin-like protein, SUMO (small ubiquitin-like modifier), to a target peptide

Other

MNX mice provide a platform for studying the role mtDNA plays in the susceptibility to diseases and disorders, based specifically on the mitochondrion’s communication with the nucleus (and vice versa).

Methods for creating MNX animals and MNX lines for study of the role of mitochondrial DNA in various diseases

Other

Investigators at UAB have identified a set of biomarkers with expression patterns that correlate with ALS disease progression.

Diagnostic assay; Companion assay