Factor VIII Inhibitor Titer  Email this article           Printer friendly page

Primary Name Factor VIII Inhibitor Titer
Synonym Bethesda Titer for Factor VIII Inhibitor
Synonym --
Contraction FVIII Inhibitor
Contraction FVIII Inh
Contraction --
UAB Procedure Number 2500490
CPT Code 85730, 85732, 85240, 85335
Specimen Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified volume. Do not underfill or overfill.

Specimen Management Centrifuge blue-stopper tube within 1 hour of collection, separate plasma and test or quick-freeze at -70°C.
Specimen Accepted Daily including weekends
Test Performed Monday-Friday.
Available Stat? No
Description Factor VIII inhibitors are IgG alloantibodies specific for therapeutic factor VIII. Factor VIII inhibitors appear in 22 to 33% of severe hemophilia patients. Inhibitors typically neutralize therapeutic factor VIII concentrates making it necessary to provide patients with alternative therapy. Autoimmune anti-factor VIII antibodies may arise in rare circumstances, causing acquired hemophilia, with severe bleeding.
Reference Interval None detected
Critical Value --
Therapeutic Range --
Associated With Bleeding disorders
Associated With Coagulation factor inhibitors
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