Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression Core
Jeong S. Hong, Ph.D.
Eric Sorscher, M.D.
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression Core assists Cystic Fibrosis (CF) Center investigators with the complex technology necessary to efficiently express CFTR in experimental systems.
The Core maintains a repository of reagents for studying CFTR, including over 50 constructs containing mutations that lead to disease and CFTR plasmid molecules used as part of gene therapy protocols in CF patients in the past. The Core also assists with expression technologies using vaccinia, adenovirus and other methodologies and antibody based detection of CF related gene products. These reagents have led to important basic discoveries about CF and to external grant funding (from the National Institutes of Health, the Cystic Fibrosis Foundation, and other sources) for UAB scientists and projects.
The Core was established in 1994 as a result of a Cystic Fibrosis Foundation award. Core users are typically associated with the Cystic Fibrosis Research Center, but there is no limitation on who may access the Core.
Core Director: Jeong S. Hong, Ph.D. and Eric Sorscher, M.D.