Dept. of Anesthesiology

Contact Information:

Office Address: BMR2 308
Phone: 205-934-4665
Websites: Dept. of Anesthesiology Faculty Page
School of Medicine Faculty Profile


Western Michigan University
BS, Chemistry and Biology, 1977

University of South Alabama
BMS, Basic Medical Sciences 1981

University of South Alabama
PhD, Physiology, 1983

Post-Graduate Training:

University of Cincinnati
Postdoctoral Fellow

Research Description:

In a variety of pathologic conditions, including coronary heart disease, ischemia-reperfusion and certain inflammatory states, reactive oxygen and nitrogen species overwhelm tissue antioxidant defenses, impair essential biochemical processes and produce extensive damage to tissues such as the vasculature and the heart. My overall research interest focuses on defining the mechanisms of reactive oxygen and nitrogen species in the cardiovascular complications associated coronary heart disease, and in particular atherosclerosis. Considerable epidemiologic data indicate that dietary polyphenols often found in red wine, reduces the morbidity and mortality associated with coronary heart disease. We have evidence that provides insight as to the mechanism by which principal components of red wine(alcohol and polyphenols) and mimetic of HDL reduce hepatic, renal, pulmonary, myocardial and vascular injury. The mechanism of this cardiovascular protection appears to be at the level of transcriptional regulation of essential cardioprotective proteins, including nitric oxide-producing (nitric oxide synthases) and superoxide scavenging proteins (superoxide dismutase isoforms). My research interests include the study of the physiologic, biochemical and cellular aspects of reactive oxygen and nitrogen metabolism. A major thrust of our investigative efforts are the identification of the source of these cytotoxic reactive species and characterization of the mechanisms of the interaction of these oxidants with biologic target molecules and the consequent altered tissue function (e.g. hepatic, pulmonary, renal, myocardial compromise and vascular dysfunction). We utilize whole animal models of disease (mouse models of atherosclerosis), ex vivo assessments of tissue function (video dimension analysis), cellular models (mouse endothelial cells from knock out animals and transfection) for study of regulation of these cardioprotective proteins and molecular systems for identification of oxidant/antioxidant-responsive elements and transcription factors. It is the ultimate goal of these projects to provide mechanistic insight into the pathoetiology of the cardiovascular disease as well as providing a rationale basis for the development of therapeutic agents designed to limit the oxidant-induced injury.


DRC Membership Category:

Senior Scientist