Dept. of Medicine
Division of Nephrology

Contact Information:

Office Address: LHRB 642
Phone: 205-934-3589
Websites: School of Medicine Faculty Profile


University of Alabama in Huntsville
BS, Chemistry, 1975

University of South Alabama College of Medicine, Mobile, AL 
MD, 1979

Post-Graduate Training:

University of Alabama Hospital, Birmingham, AL 
Intern, Internal Medicine, 1979-80

University of Alabama Hospital, Birmingham, AL 
Resident, Internal Medicine, 1980-2

University of Alabama at Birmingham School of Medicine, Birmingham, AL 
Fellow, Nephrology Research & Training Center, 1982-5

Research Interests:

Mechanisms of progressive renal injury, related to:

  • Monoclonal immunoglobulin light chain-related renal diseases, including acute kidney injury, cast nephropathy, monoclonal light chain-related glomerulopathy and amyloidosis, type AL
  • Hypertensive nephrosclerosis
  • Chronic allograft nephropathy
  • Proteinuria

Dietary salt and salt-sensitive hypertension
Transforming growth factor-ß
Nitric oxide-dependent signaling and reactive nitrogen species
Acute kidney injury and repair

Research Description:

Paul W. Sanders, M.D., is a translational researcher interested in the pathogenesis of salt-sensitive hypertension and hypertensive nephrosclerosis as well as the mechanism of kidney damage from immunoglobulin light chains.  Ongoing research includes: 1) the role of endothelial Pyk2 and c-Src in signaling induced by salt ingestion; 2) the mechanism of intravascular production of TGF-ß1; 3) the mechanism by which light chain-induced oxidative stress activates c-Src in renal epithelium.


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