Antihypertensives Combined with Exercise for Seniors with Hypertension

The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension. Sedentary men and women > 60 years of age with functional limitations and hypertension will be recruited from two sites to participate in a longitudinal intervention trial. Participants will be randomly assigned to one of three first-line antihypertensive agents and participate in a structured aerobic exercise intervention. This study is expected to differentiate beneficial effects of three FDA-approved antihypertensive medications on established and emeriging cardiovascular risk factors in a clinically-relevant population.

Funding: NIH R01AG056769

Principal Investigators:
Thomas Buford, PhD, University of Alabama at Birmingham; Wedny Kohrt, PhD, University of Colorado

Participants: 60 years of age and older; functional limitations; hypertension.

If you may be interested in participating and want to learn more, please complete the questionnaire below and a member of our research staff will contact you soon. You may also call 205-996-3005. Thank you for your interest.

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