Precision High-Intensity Training Through Epigenetics

The US Department of Defense (DoD) is looking for ways to overcome inadequate physical fitness that challenges a warfighter’s readiness. The PHITE Trial is designed to help meet this challenge. Supported by the DoD Office of Naval Research (ONR), PHITE is a 12-wk, two-arm, single-blind, randomized, exercise dose-response trial comparing two intensities of combined exercise training – Moderate Intensity vs. High-Intensity – to determine the effect of exercise dose on performance optimization and the underlying molecular mechanisms, with a focus on epigenetics. The term epigenetics refers to heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence; i.e. a change in phenotype (the set of observable characteristics of an individual resulting from the interaction of its genotype with the environment) without a change in genotype (the genetic constitution of an individual organism). This in turn affects how cells read the genes. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state. The PHITE Trial is designed to assess whether epigenetics is a primary mechanism modulating how individuals adapt to specific exercise training prescriptions designed to produce a warfighter phenotype.

The PHITE collaborative team consists of Tim Broderick, MD (Overall PI), Wright State University (WSU); Marcas Bamman, PhD (Site PI), The University of Alabama at Birmingham (UAB); and Ron Evans, PhD and Joe Ecker, PhD, Salk Institute for Biological Studies. The team is organized around a shared test population of human subjects for which UAB oversees all recruitment, training, testing, and sampling. Healthy but untrained volunteers, both men and women, 18-27 y of age, similar to the US warfighter, are being recruited.

Come join the PHITE Club!

Funding: The United States Department of Defense

Principal Investigators:
Timothy Broderick, PhD, Wright State University; Marcas Bamman, PhD, University of Alabama at Birmingham

Benefits:
Participants will receive supervised exercise training with certified trainers, valuable information about their health, and compensation for their time.

Participants:
18-27 years of age; no history of regular endurance or resistance training within the past year; must meet all other inclusion and exclusion criteria determined during screening.

If you may be interested in participating and want to learn more, please complete the questionnaire below and a member of our research staff will contact you soon. You may also call 205-996-0855. Thank you for your interest.


PHITE Trial Interest Form

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