Overcoming TWEAK Signaling to Restore Muscle and Mobility after Joint Replacement

This randomized clinical trial is designed to test the central hypothesis that progressive resistance training plus functional mobility training after total hip replacement or total knee replacement will more effectively restore muscle mass and mobility function to healthy standards than usual care and, because individuals with abnormally high muscle TWEAK signaling are predicted to suffer failed muscle recovery and persistent dismobility under usual care, the impact of the intervention will be greatest among these patients.

Funding: NIH R01HD084124
Principal Investigators: Marcas Bamman, PhD; Lou Bridges, MD, PhD
Institutions: UAB and UAMS
ClinicalTrials.gov Identifier: NCT02628795

If you may be interested in participating and want to learn more, please complete the questionnaire below and a member of our research staff will contact you soon. You may also email tweaktrial@uab.edu or call 205-996-3005. Thank you for your interest.

 

TWEAK Trial Interest Form

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