Overcoming TWEAK Signaling to Restore Muscle and Mobility after Joint Replacement
|This randomized clinical trial is designed to test the central hypothesis that progressive resistance training plus functional mobility training after total hip replacement or total knee replacement will more effectively restore muscle mass and mobility function to healthy standards than usual care and, because individuals with abnormally high muscle TWEAK signaling are predicted to suffer failed muscle recovery and persistent dismobility under usual care, the impact of the intervention will be greatest among these patients.
Funding: NIH R01HD084124
Principal Investigators: Marcas Bamman, PhD; Lou Bridges, MD, PhD
Institutions: UAB and UAMS
ClinicalTrials.gov Identifier: NCT02628795
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