UCEM's clinical trials are aimed at studying mechanisms underpinning skeletal muscle atrophy and neuromuscular dysfunction, and exercise-induced health benefits in disease prevention, treatment and rehabilitation.

“This is not about exercise for weight loss or simply feeling better; rather, we are striving to understand the role of exercise as medicine at the molecular, cellular and clinical levels," says Marcas Bamman, PhD, FACSM, UCEM Director. "It’s not enough to simply tell someone they should exercise more. We need to be able to present precise exercise prescriptions to patients that include evidence-based dosing — frequency, intensity and type of exercise — that will be most effective in helping that patient improve health, reduce disease burden, or recover from an event such as trauma or surgery."

Volunteer for our ongoing clinical trials below and help UCEM understand the role of exercise as medicine! 

ACES Trial

The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension. Sedentary men and women > 60 years of age with functional limitations and hypertension will be recruited from two sites to participate in a longitudinal intervention trial. Participants will be randomly assigned to one of three first-line antihypertensive agents and participate in a structured aerobic exercise intervention. This study is expected to differentiate beneficial effects of three FDA-approved antihypertensive medications on established and emeriging cardiovascular risk factors in a clinically-relevant population.

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MoTrPAC

Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a national research consortium designed to discover and perform preliminary characterization of the range of molecular transducers (the "molecular map") that underlie the effects of physical activity in humans. The program's goal is to study the molecular changes that occur during and after exercise and ultimately to advance the understanding of how physical activity improves and preserves health. The six-year program is the largest targeted NIH investment of funds into the mechanisms of how physical activity improves health and prevents disease.

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PHITE Trial

The US Department of Defense (DoD) is looking for ways to overcome inadequate physical fitness that challenges a warfighter’s readiness. The PHITE Trial is designed to help meet this challenge. Supported by the DoD Office of Naval Research (ONR), PHITE is a 12-wk, two-arm, single-blind, randomized, exercise dose-response trial comparing two intensities of combined exercise training – Moderate Intensity vs. High-Intensity – to determine the effect of exercise dose on performance optimization and the underlying molecular mechanisms, with a focus on epigenetics.

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