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|Title:||2013-2014 Rich Lecture Seminar|
|Calendar:||Ophthalmology Calendar of Events|
|Date:||10.23.2013 12:00 pm - 1:00 pm|
|Location:||Callahan Eye Hospital, 3rd Floor, Smith Education Center|
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DescriptionSpeaker Colm O'Brien, M.D.,FRCS, FRCOphth, FARVO, a professor of Ophthalmology at University College Dublin and consultant ophthalmic surgeon at Mater Misericordiae University Hospital will present "Therapeutic targets for lamina cribrosa cupping/fibrosis in glaucoma."
The focus of our research group is to identify the underlying biological mechanisms that lead to connective tissue re-modelling and fibrosis in the lamina cribrosa in human glaucoma. Using in-vitro experimental methods (cylic mechanical stretch, hypoxia, TGFβ), have attempted to mimic the glaucoma associated phenotypic gene profile in the alpha SMA positive lamina cribrosa cells. We have identified abnormal mechanisms including evidence of oxidative stress, calcium dysregulation, authophagy and an elevation in the mechano-sensitive maxi-k ion channel current in the glaucoma phenotype. We are exploring therapeutic options to prevent the development of fibrotic changes using a variety of approaches including calcium entry channel inhibition and connective tissue growth factor therapeutic antibodies. Our long term goal is to improve the understanding of the disease mechanisms that will lead to new therapeutic approaches to the management of patients with glaucoma.