We develop and apply a novel high throughput phenotyping methodology (yeast phenomic analysis) to leverage the awesome power of yeast genetics for understanding, globally, the interactions between genetic and/or environmental factors that influence cellular function. By focusing yeast phenomic studies within a disease-relevant context, evolutionarily conserved gene interaction networks are discovered. Gene networks give rise to hypotheses that can be tested in animal or human cell models to advance knowledge about the complexity of disease and phenotypic expression, thereby advancing the capability for precision medicine.