Genetics and Genomics Seminar Series
2022-2023
Archive
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2022-2023
Friday, Nov 18, 2022
"AR Variant Biogenesis, PARP Inhibitor Sensitivity and Tumor Immunity in CDK12-Mutated Prostate Cancer"
Haokie Huang, Ph.D.
Professor, Director of Basic Urologic Research, Co-Director of the Genitourinary Cancer Program
Professor of Biochemistry and Molecular Biology and Urology, Mayo Clinic
Friday, Nov 11, 2022
"The All of Us Research Program"
Bruce R. Korf, M.D., Ph.D.
Department of Genetics
Wayne H. and Sara Crews Finley Endowed Chair in Medical Genetics
Associate Dean for Genomic Medicine, UAB Heersink School of Medicine
Chief Genomics Officer, UAB Medicine
Friday, Nov 4, 2022
"Correlation Between DNA Methylation Patterns, Gene Expression, and Human Heart Failure Etiologies"
Adam R. Wende, Ph.D.
Associate Professor, Department of Pathology
Molecular and Cellular Pathology (UAB)
Friday, Oct 28, 2022
"Redox Regulation by Tryptophan Metabolism: An Emerging Mechanism for Adaptive Immunomodulatory Signaling"
Dario A. Vitturi, Ph.D.
Assistant Professor, Molecular and Cellular Pathology (UAB)
Friday, Oct 21, 2022
"Targeting PI3K/AKT/PTEN Pathway in Cancer"
Jia Xu, Ph.D.
Assistant Professor, Department of Genetics (UAB)
Friday, Oct 14, 2022
"Optimizing Metabolomic Detection of Aromatic Amino Acid Decarboxylase (AADC) Deficiency, A Rare (But Likely Underdiagnosed) Disorder of Neurotransmitter Metabolism"
J. Daniel Sharer, Ph.D.
Professor and Interim Director, Research, Department of Genetics (UAB)
Friday, Oct 7, 2022
"Interleukin-17 and Prostate Cancer"
Zongbing You, M.D., Ph.D
Professor, Department of Structural and Cellular Biology
Tulane University School of Medicine
Friday, Sept 30, 2022
"Cellular Heterogeneity in Therapeutic Resistance and Disease Progression of Prostate Cancer"
Jiaoti Huang, M.D.
Professor and Chairman, Department of Pathology
Duke University Medical Center
Friday, Sept 16, 2022
"Proteogenomics Opens New Frontiers in Cancer Systems Biology"
Chen Huang, Ph.D.
Assistant Professor, Genetics Research Division (UAB)
Friday, Sept 9, 2022
"TUBB4A Function and Mediated Signaling in Prostate Cancer"
Lizhong Wang, M.D., Ph.D.
Associate Scientist, Comprehensive Neuroscience Center, General Clinical Research Center (UAB)
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2021-2022
Friday, Sept. 3, 2021
“Genetic Testing of Neurofibromatosis”
Juan Dong, PhD
Associate Professor, Department of Genetics
Director, Medical Genomics Laboratory
Friday, Sept. 3, 2021
“Mitochondria in Health and Disease”
Keshav K Singh, Ph.D.
Joy and Bill Harbert Endowed Chair in Cancer Genetics
Professor of Genetics, Pathology and Environmental Health
Friday, Aug. 27, 2021
“Patient Specific Neurofibromatosis Type 1 Animal Models: Translational Studies and Therapeutic Approaches”
Robert Kesterson, Ph.D.
Professor with Tenure
Department of Genetics
University of Alabama at Birmingham
Friday, Aug. 20, 2021
“Genetic and Epigenetic Regulation of Heart Development”
Kai Jiao, MD, PhD
Professor and Interim Director, Research
Department of Genetics
Friday, July 23, 2021
“DNA replication initiation and genome instability”
Anindya Dutta M.D., Ph.D.
Professor/Chairman, Department of Genetics at UAB
Friday, July 16, 2021
“Microbiome, metabolome, multi-omics…hype or path to precision biomedicine?”
Tatiana T. Marquez Lago, Ph.D.
Associate Professor
Department of Genetics
Friday, July 9, 2021
“Genomic tools for third-generation sequencing data analysis”
Zechen Chong, Ph.D.
Assistant Professor, Genetics and Informatics Institute at UAB
Friday, July 2, 2021
“Using CRISPR to Create Precision Animal Models”
Laura J. Lambert, Ph.D.
Assistant Professor, Department of Genetics -
2020-2021
Friday, May 21
“Protein monoaminylation in brain: novel mechanisms of neural development, plasticity and disease”
Ian S. Maze, Ph.D.
Associate Professor
Friedman Brain Institute, Nash Family Department of Neuroscience
Icahn School of Medicine at Mount Sinai in New York City
Friday, May 14
“Novel Mechanisms of Oncogenesis and Metastasis”
Mick D. Edmonds, MS, Ph.D.
Assistant Professor
UAB Department of Genetics
Friday, May 7
“Phenomic Modeling”
John Hartman, M.D.
Associate Professor, Department of Genetics
Friday, April 23
“Direct Cardiac Reprogramming: How to Create New Cardiomyocytes?”
Yang Zhou, Ph.D.
Assistant Professor
UAB Department of Biomedical Engineering
Friday, March 5
“Investigating Key Genetic Regulators in Small Cell Lung Cancer”
Michael Kareta, Ph.D.
Associate Scientist
Sanford Research, Sioux Falls, SD
Friday, January 15
“Pathophysiological Basis and Mitigation for Cardiometabolic and Genetic Disorders”
Girish C. Melkani, Ph.D.
Associate Professor
Department of Pathology. Division of Molecular and Cellular Pathology
University of Alabama at Birmingham
Friday, December 11
“Epithelial FOXP3-regulated network and targeted cancer therapies”
Lizhong Wang, Ph.D.
Associate Professor
UAB Department of Genetics
Friday, November 20
“Feasibility and Potential Impact of Exon Skipping as a Therapeutic for Neurofibromatosis Type I (NF1)”
Deeann Wallis, Ph.D.
Associate Professor
UAB Department of Genetics
Friday, November 6
“Sifting through Data from Clinical Genomes - When is a Case 'Solved'?”
Elaine Lyon, Ph.D.
Research Faculty Investigator, HudsonAlpha
Huntsville, Alabama
Friday, Oct. 23
“Mitochondria Based Priming of Stem Cell Self-Renewal: From Basic Science to its Translation”
Kasturi Mitra, Ph.D.
Assistant Professor. Department of Genetics
Co-Director, GGSC Undergraduate Program
Friday, Oct. 16
“UAB Genomic Medicine”
Bruce R. Korf, M.D., Ph.D.
Wayne H. and Sara Crews Finley Endowed Chair in Medical Genetics
Associate Dean for Genomic Medicine, UAB School of Medicine
Chief Genomics Officer, UAB Medicine -
2019-2020
Friday, February 28 | “Understanding and Targeting Glioblastoma Environmental Effects: A Focus on Glucose Transporters” | Anita Hjelmeland, Ph.D., Associate Professor, Department of Cell, Development and Integrative Biology, University of Alabama at Birmingham
Friday, December 13 | “Targeting α2AAR: Solution for Alzheimer’s Disease” | Qin Wang, Ph.D., Professor, Department of Cell, Developmental and Integrative Biology, UAB
Friday, December 6 | “Bioactive Retinoic Acid: Gene knockouts reveal unexpected roles” | Natalia Y. Kedishvili, Ph.D., Professor, Department of Biochemistry and Molecular Genetics, UAB
Friday, November 22 | “Selective RANK Signaling Pathways as Novel Drug Targets for Breast Cancer Prevention” | Xu Feng, Ph.D., Professor, Department of Pathology
Friday, November 15 |“Population Genetics in an era of Precision Medicine” | Eimear Kenny, Ph.D., Director, Center for Genomic Health, Associate Professor of Medicine, Associate Professor of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Friday, November 8 | “The identification and targeting of novel oncogenic ncRNA in human cancer” | Mick Edmonds, Ph.D., Assistant Professor, Genetics Research Division, Department of Genetics, UAB
Friday, November 1 | "Computational Drug Repositioning Strategies for Precision Medicine 2.0" | Jake Chen, Ph.D., Chief Bioinformatics Office, Professor, Department of Genetics, Informatics Institute, UAB
Friday, October 25 | “Mathematical modeling: Aiding biomedical discoveries" | Andre Leier, Ph.D., Assistant Professor, Department of Genetics, Assistant Professor, Department of Cell, Developmental and Integrative Biology, Associate Scientist, O’Neal Comprehensive Cancer Center, Member, Gregory Fleming James Cystic Fibrosis Research Center
Friday, October 18 | “Clinical Application of Genome Sequencing: The Children’s of Alabama Experience” | Anna C.E. Hurst, M.D., MS, FACMG, Assistant Professor,Department of Genetics,UAB
Friday, September 27 | “Fluid-Mosaic Membrane in Aging, Disease and Mitochondrial Function and The use of Membrane Lipid Replacement to Reduce Fatigue, Pain and Other symptoms while Improving Mitochondrial Function” | Garth Nicolson, Ph.D., M.D., Professor Emeritus, President and Founder, The Institute for Molecular Medicine, Huntington Beach, CA
Friday, September 13 | “From Genetic to Pharmacological Inhibition of TXNIP- Effects on Diabetes” | Anath Shalev, M.D., Professor of Medicine - Endocrinology, Diabetes & Metabolism, Nancy R. and Eugene C. Gwaltney Family Endowed Chair in Juvenile Diabetes Research, Director, UAB Comprehensive Diabetes Center
Friday, September 6 | “Genetic and epigenetic regulation of Duchenne muscular dystrophy” | Matthew S. Alexander, Ph.D., Assistant Professor, UAB Pediatric Neurology
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2018-2019
Friday, May 17 | “Implementation of a Personalized Medicine Program Across a Community Health System” | Peter J. Hulick, M.D., MMSc, FACMG, Medical Director, Mark R. Neaman Center for Personalized Medicine Division, Head, Center for Medical Genetics NorthShore University HealthSystem, Clinical Assistant Professor, University of Chicago, Pritzker School of Medicine
Friday, May 10 | “STAT3: From Fundamental Discoveries to Novel Targeting Platforms” | Hua Yu, Ph.D., Billy and Audrey L. Wilder Professor in Tumor Immunotherapy, Associate Chair and Professor, Department of Immuno-Oncology, Co-leader, Cancer Immunotherapeutics Program, City of Hope Comprehensive Cancer Center
Friday, May 3 | “InterGenomic Cross Talk Underlying Aging and Cancer” | Keshav K. Singh, Ph.D., Joy and Bill Harbert Endowed Chair in Cancer Genetics and professor, Department of Genetics University of Alabama at Birmingham
Friday, April 19 | “Enhancing Precision Oncology at UAB” | Eddy S. Yang, M.D., Ph.D., Professor, Vice Chair for Translational Science, Department of Radiation Oncology, University of Alabama at Birmingham
Friday, April 12 | “Genetics and Epigenetic Regulation of Heart Development in Mice” | Kai Jiao, M.D., Ph.D., Associate Professor, Department of Genetics, Genetics Research Division, University of Alabama at Birmingham
Friday, March 22 | “The Impact of Geometry, Diffusion Barriers and Stochasticity in Cell Polarity and Protein Dynamics” | Tatiana Marquez-Lago, Ph.D., Associate Professor, Department of Genetics, Research Division, University of Alabama at Birmingham
Friday, March 15 | “Functional characterization of human disease-associated gene variants using the vertebrate animal model Xenopus laevis” | Chenbei Chang, Ph.D., Professor, Department of Cell, Developmental and Integrative Biology, UAB
Friday, March 8 | “RAS and the Plasma Membrane: A Complicated Relationship” | John Hancock, MA MB BChir PhD ScD MRCP FRACP, Professor and Chairman, Department of Integrative Biology and Pharmacology, Executive Director, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center
Friday, February 22 | “Epithelial Homeostasis in Development and Disease” | Ian G. Macara, PhD, Professor and Louise B. McGavock Chair, Department of Cell and Development Biology, Vanderbilt University Medical Center
Friday, February 15 | “Structural Variations of the Immunoglobulin Receptors and
Clinical Phenotype” | Robert P. Kimberly, M.D., Director, Center for Clinical and Translational Science University of Alabama at Birmingham
Friday, February 1 | “A Novel Technology Developed at UAB for Phenomic Research and Drug Discovery” | John L. Hartman IV, M.D., Associate Professor, UAB Department of Genetics
Friday, January 18 | "Polycystic Kidney Disease-Treatment Options Update" | Michal Mrug, M.D., Professor of Medicine, Department of Nephrology
Friday, January 11 | “The algorithm for precision medicine” | Matthew Might, Ph.D., Professor of Computer Science, Director, UAB’s Hugh Kaul Precision Medicine institute, University of Alabama at Birmingham
Friday, December 14 | “Molecular profiling in ovarian cancer” | Rebecca C. Arend, M.D., Assistant Professor, Department of Obstetrics and Gynecology, University of Alabama at Birmingham
Friday, December 7 | “Epithelial-mesenchymal Transition in Breast Cancer Progression and Metastasis” | Binhua (Peter) Zhou, M.D., Ph.D., Co-Director, Center of Biomedical Research Excellence in Cancer and Metabolism, University of Kentucky, Lexington, KY
Friday, November 30 | "A Mitochondrial Etiology of Common 'Complex' Diseases" | Douglass C. Wallace, Ph.D., Professor, Department of Pathology and Laboratory Medicine, University of Pennsylvania
Monday, November 19 | "Design and evolution of trans-splicing group I intron ribozymes" | Ulrich F. Muller, Ph.D., Associate Professor, Department of Chemistry and Biochemistry, University of California at San Diego
Friday, November 2 | “Unraveling the complex roles of SIN3 in breast cancer metastasis”| Douglas R. Hurst, Ph.D., Assistant Professor, Department of Pathology, University of Alabama at Birmingham
Friday, October 19 | "Patient-Specific NF1 Rodent Models & Gene Correction Therapies" | Robert A. Kesterson, Ph.D., Professor, Department of Genetics, UAB
Friday, October 12 | "The ELMOD family of ARF family GAPs: roles in mitochondria, cell cycle, ciliogenesis, and transcriptional regulation" | Richard A. Kahn, Ph.D., Professor, Department of Biochemistry, Emory University
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2017-2018
March 9, 2018 | Phillip Owens, Ph.D. | University of Colorado
March 16, 2018 | Richard Finnell, Ph.D. | Baylor College of Medicine
March 23, 2018 | Anthony Wynshaw-Boris, M.D., Ph.D. | Case Univeristy
April 4, 2018 | Nita Limdi, PharmD, Ph.D. | UAB
April 13, 2018 | Chulan Kwon, MS, Ph.D. | John Hopkins University
April 20, 2018 | Merry-Lynn McDonald, Ph.D. | University of Alabama at Birmingham
May 4, 2018 | Mikhail Alexeyev, Ph.D., I University of South Alabama
May 11, 2018 | Jiangbing Zhou, Ph.D. I Yale University
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2016-2017
Date
Speaker
Institution
Title
9/2/2016 Margaret R. "Peggy" Wallace Indiana University Molecular and Cellular Studies of Neurofibromatosis 1 9/9/2016 9/16/2016 Vidu Garg, MD Nationwide Children's Hospital Insights into the genetics of congenital heart disease:
From human genetics to mouse models9/23/2016 STATE DEPT MEETING 9/30/2016 10/7/2016 Jake Chen Journal Club 10/14/2016 IMMERSON COURSE 10/21/2016 10/26/2016 11/4/2016 Gabrielle Geddes, M.D. Medical College of Wisconsin/ Children's Hospital of Wisconsin Ciliopathies and Congenital Heart Disease 11/11/2016 Patty Sanderson Journal Club 11/18/2016 SCIENTIFIC RETREAT 11/25/2016 12/2/2016 Brian Spurlock Journal Club Mechanisms of Autophagy as discovered by Dr. Yoshinori Oshumi Nobel Prize in Physiology or Medicine, 2016 12/9/2016 Sophie Astrof, PhD Thomas Jefferson University Cell type-specific function of fibronectin in cardiovascular development 12/16/2016 12/30/2016 1/6/2017 Li, Yi, PHD
*This lecture will take place from 2 - 3 p.m. in the Finely Conference Room
Baylor College of Medicine` Unexpected players in cancer metastasis 1/13/2017 Joy Dean Journal Club 1/20/2017 1/27/2017 2/3/2017 Benjamin Tu, PhD UT-Southwestern University A metabolic vulnerability of tumors revealed by yeast 2/10/2017 2/17/2017 Jariya Upadiya Journal Club Fox transcription factors in cardiovascular development 2/24/2017 Barbara K Burton MD Ann & Robert H. Lurie Children’s Hospital of Chicago Lysosomal Acid Lipase Deficiency 3/3/2017 RARE DISEASE SYMPOSIUM 3/10/2017 Dr. Kume Tsutomu Northwestern University Fox transcription factors in cardiovascular development 3/17/2017 Bruce Walcheck University of Minnesota Regulating Receptor Levels on Leukocytes to Improve Their Function During Disease 3/24/2017 Stephen Dalton University of Georgia “MYC coordinates metabolic control with pluripotent stem cell fate decisions” 3/31/2017 4/7/2017 Dr. David Gutmann Washington Univ Neurofibromatosis Center
Neurofibromatosis: New Insights from an Old Gene4/14/2017 Danny Welch, PhD Univ of Kansas Medical Center The forgotten genome: Surprising roles of mitochondria in cancer metastasis. 4/21/2017 Genetics Graduation - Robert Marion Albert Einstein College of Medicine 4/28/2017 Deborah Yelon Univ of California San Diego “Molecular Mechanisms Regulating Cardiac Architecture in Zebrafish” 5/5/2017 Dr. Prabhat Goswami A redox cycle within the cell cycle: ring in the old with the new. 5/12/2017 Deeann Wallis, PhD Journal Club 5/19/2017 IMMERSION COURSE 5/26/2017 Shizen (Emily) Wang, Ph.D Seminar Series “Cancer-derived extracellular miRNA in breast cancer metastasis”. 6/9/2017 Dr. Melissa Harris Uncovering gene regulatory networks for somatic stem cell self-renewal. 9/29/2017 Dr. Elizabeth Worthey John Hartman Preparing for the Precision Medicine Revolution: Transforming Whole Genome Sequencing Data into Clinically Actionable Knowledge -
2015-2016
Date Speaker Institution Title 09/04/2015 09/11/2015 09/18/2015 State Department Meeting 09/25/2015 10/02/2015 10/09/2015 10/16/2015 Journal Club-
Justin AveryUAB 10/23/2015 Dr. Sunjung Kim Children's National Medical Center "The Role of Tumor Suppressor genes in Central Nervous System (CNS) Disorder 10/30/2015 Deeann Wallis, Ph.D Texas A&M University "High-Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host-Based Genes Involved in Infection' 11/06/2015 Journal Club-
Ved Prakash MoogaUAB 11/13/2015 Areeg El-gharbawy University of Pitsburg 11/20/2015 11/27/2015 Thanksgiving holiday 12/04/2015 Journal Club-
Akila SubramaniumUAB 12/11/2015 Joy Lincoln , Ph.D Nationwide Children's Hospital Research Institute 12/18/2015 Stanley Lei Qi, PhD Stanford University 12/25/2015 Holiday 01/01/2016 Holiday 01/08/2016 01/15/2016 Day before MLK Weekend 01/22/2016 Journal Club -
Kasturi Mitra, Ph.DUAB 01/29/2016 Ivan Moskowitz, MD, PhD University of Chicago "Gene Regulatory Networks in Cardiac Development and Homeostasis" 02/05/2016 Mick Edmonds, PhD, MS Vanderbilt University Medical Cente 02/12/2016 Cancelled- Rescheduled for March 4. 02/19/2016 Toren Finkel NIH "Mitochondria and Aging" 02/26/2016 Joy Lincoln , Ph.D Nationwide Children's Hospital Research Institute "Exploring heart valve endothelial cell dynamics" 03/04/2016 Journal Club-
Ashley TurnerUAB 03/11/2016 Stanley Lei Qi, PhD Stanford University "CRISPR/Cas9 for complex genome regulation and disease modeling" 03/18/2016 Journal Club-
Austin HammUAB 03/25/2016 Spring Break 04/01/2016 Spring Break 04/08/2016 Vishal Gohil Texas A & M University "Discovering novel mitochondrial disease genes by integrative genomics" 04/15/2016 Journal Club-
Sean SantosUAB 04/20/2016 Woojin An, Ph.D., University of Southern California “Chromatin dynamics and gene regulation” 04/22/2016 Todd Lowe, Ph.D. University of California Santa Cruz Unraveling the Complex Roles for 500+ Human tRNA Genes and their Ubiquitous Small RNA Fragments 04/29/2016 Maria Alejandra San Martin, PhD Emory University “Diverse roles of NADPH oxidases in the VSMC phenotype” 05/06/2016 Anil Shanker, PhD Meharry Medical College School of Medicine "Preventing Immune Escape Variants of Cancer" 05/13/2016 05/20/2016 Brian Kennedy, PH.D. / LRC-235 Buck Institute for Aging “The Age of Aging – Can We Intervene?” 05/27/2016 Jing Yang PhD University of California, San Diego "Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis" 06/17/2016 Journal Club-
Anna HurstUAB -
2014-2015
Date Speaker Institution Title 09/12/2014 Bruce Korf, M.D., Ph.D. Professor and Chair, Department of Genetics, UAB State of the Department Address 09/19/2014 No Seminar 09/26/2014 Rebecca Dodd, Ph.D. Senior Research Associate, Duke University Medical Center "New Mice for Old Questions: Modeling Soft-tissue Sarcoma" 10/03/2014 No Seminar 10/10/2014 Todd Nystul, Ph.D. Assistant Professor, University of California San Francisco "To Be (Stem) or Not to Be: Polarity and pH Define Cell Fate in an Epithelial Stem Lineage" 10/17/2014 Becky Nagy, MD, LGC Assistant Professor, The Ohio State University "The Use of Next Generation Sequencing in Novel Gene Discovery: A Tale of Two Cities" 10/24/2014 Journal Club- Trevor Carden UAB 10/31/2014 Sean Wu, MD, Ph.D Professor, Stanford University "Molecular Regulation of Cardiac Development: Implications in Regenerative Therapy" 11/07/2014 Hudson Alpha Retreat- NO SEMINAR N/A N/A 11/14/2014 Journal Club-Anil Challa UAB 11/21/2014 Anil Challa, Ph.D Instructor, University of Alabama at Birmingham 11/28/2014 Thanksgiving Holiday N/A N/A 12/05/2014 Hyeong-Reh Choi Kim, Ph.D. Assistant Professor, Wayne State University "A Novel Function of PDGF D in Prostate Cancer Bone Metastasis: New Biology of an Old Growth Factor Family Member" 12/12/2014 No Seminar 12/19/2014 Journal Club- Warren L Simmons UAB 12/26/2014 Christmas Holiday N/A N/A 01/02/2015 New Years Holiday N/A N/A 01/09/2015 Mark Gillespie, Ph.D. Professor and Chairman Dept. of Pharmacology, University of South Alabama 01/16/2015 MLK Holiday N/A N/A 01/23/2015 William Pu, MD. Harvard Medical School 01/30/2015 Journal Club- Bob Kesterson UAB 02/06/2015 No Seminar 02/13/2015 No Seminar 02/20/2015 Journal Club- Wei Zhang UAB 02/27/2015 No Seminar 03/06/2015 Matt R. Kaeberlein, Ph.D. University of Washington 03/13/2015 Rocio Moran, MD Associate Staff, Cleveland Clinic 03/20/2015 Journal Club-Haley D. Albright 03/27/2015 Spring Break 04/03/2015 Spring Break 04/10/2015 Bhupendra Singh, Ph.D. Instructor, University of Alabama at Birminhgam 04/17/2015 Randal Voss, Ph.D. Professor, Biology, University of Kentucky 04/24/2015 Day Before Commencement 05/01/2015 No Seminar 05/08/2015 Journal Club- Ying Peng UAB 05/15/2015 Anita Hjelmeland, Ph.D. Assistant Professor, UAB 05/22/2015 No Seminar 05/29/2015 Journal Club- Justin Avery UAB