Genetics and Genomics Seminar Series

Friday, Sep 22, 2023

"Therapeutic Insights from Cancer Mutational Signatures”

Samuel Brady, Ph.D.
Assistant Member, Pharmacy & Pharmaceutical Sciences
St Jude Children's Research Hospital

Friday, Sep 15, 2023

"Epitranscriptomics: RNA Modifications in Gene Regulation”

Zhangli Su, Ph.D.
Assistant Professor, Department of Genetics
The University of Alabama at Birmingham

Friday, Aug 4, 2023

"nc886, a Multi-functional Noncoding RNA Implicated in Innate Immunity, Cancer, and More"

Yong Sun Lee, Ph.D.
Department of Cancer Biomedical Science
Graduate School of Cancer Science and Policy
National Cancer Center (Goyang, Korea)

Friday, July 7, 2023

"LCN2 Promotes Therapy Resistance and Tumor Progression in Colorectal Cancer"

Professor Sorab N. Dalal, Ph.D.
Cell and Tumor Biology, Advanced Centre for Treatment Research and Education in Cancer (ACTREC)
Tata Memorial Centre

Friday, June 30, 2023

"Mitochondria in Health and Disease"

Keshav K. Singh, Ph.D.
Professor of Genetics, Pathology and Dermatology
The University of Alabama at Birmingham

Friday, June 23, 2023

"A Decade of Dysmorphology and Discovery: Insights from Care4Rare Canada"

A. Micheil Innes, MD, FRCPC, FCCMG
Department of Medical Genetic and Pediatrics, Alberta Children's Hospital Research Institute
Cumming School of Medicine
The University of Calgary

Friday, June 16, 2023

"Intrinsic and Extrinsic Immunosuppression in Cancer"

Xin Lu, Ph.D.
Department of Biological Sciences
The University of Notre Dame

Friday, June 9, 2023

"Telomere-Dependent lmmunosuppression within the Tumor Niche"

Shantanu Chowdhury, Ph.D.
Professor
Functional Genomics and Integrative Biology
CSIR - Institute of Genomics and Integrative Biology

Friday, June 2, 2023

"Roles of Alternative RNA Splicing in Therapy-Resistant Prostate Cancers"

Xuesen Dong, MD, Ph.D.
Department of Urologic Sciences
The University of British Columbia

Friday, May 26, 2023

"SQSTM1/p62 Oxidation and Oxidative Stress Response"

Benyi Li, MD/Ph.D.
Professor of Urology
Department of Urology
The University of Kansas Medical Center

Friday, May 19, 2023

"LSDl-FOXAl: A New Epigenetic Complex in Cancer Development"

Changmeng Cai, Ph.D.
Associate Professor, Center for Personalized Cancer Therapy
University of Massachusetts Boston

Friday, May 12, 2023

"Epigenetic Mechanisms in Cancer Development and Therapy"

Rui Lu, Ph.D.
Assistant Professor
Department of Medicine - Hematology & Oncology
University of Alabama at Birmingham

Friday, May 5, 2023

"Leveraging Bone-mediated Tumor Adaptation as a Therapeutic Strategy for Secondary Metastasis"

Julienne L. Carstens, Ph.D.
Assistant Professor
School of Medicine, Division of Hematology and Oncology
O'Neal Comprehensive Cancer Center
University of Alabama at Birmingham

Friday, Apr 21, 2023

"The Functional Heterogeneity of Pancreatic Tumor Cells"

Julienne L. Carstens, Ph.D.
Assistant Professor
School of Medicine, Division of Hematology and Oncology
O'Neal Comprehensive Cancer Center
University of Alabama at Birmingham

Friday, Apr 7, 2023

"Tumor Cell Intrinsic and Extrinsic Determinants for Prostate Cancer Aggressiveness"

Li Xin, Ph.D.
Professor, Institute for Stem Cell & Regenerative of Medicine
University of Washington

Friday, Mar 31, 2023

"Resistance to Targeted Therapy in HER2-positive Breast Cancer"

Bolin Liu, MDProfessor, Department of Interdisciplinary Oncology
LSU Health New Orleans

Friday, Mar 17, 2023

"Modulating Chromatin Dynamics: A Promising Strategy for Cardiovascular Disease Prevention"

Manuel Rosa-Garrido, Ph.D.
Assistant Professor
Department of Biomedical Engineering
University of Alabama at Birmingham

Friday, Mar 10, 2023

"AKT Isoform-preferred Substrates as Drivers of Prostate Cancer Aggressiveness"

Irwin Gelman, Ph.D.
Distinguished Professor of Oncology
Department of Cancer Genetics & Genomics
Roswell Park Comprehensive Cancer Center

Friday, Mar 3, 2023

"Personalized Prediction of Disease Risk and Targets based on the Full Genome Architecture"

Kuan-lin Huang, Ph.D.
Assistant Professor of Genetics and Genomics
Mount Sinai Center for Transformative Disease Modeling
Icahn School of Medicine at Mount Sinai

Friday, Feb 24, 2023

"Weight Matters: Unraveling the Molecular Variations in Cancer Patients"

Zechen Chong, Ph.D.
Assistant Professor of Genetics, Department of Biochemistry and Molecular Genetics
The University of Alabama at Birmingham

Friday, Feb 17, 2023

"Circular RNAs: Biogenesis, Detection, Function and Role in Disease"

Andre Leier, Ph.D.
Assistant Professor, Department of Biochemistry and Molecular Genetics
The University of Alabama at Birmingham

Friday, Feb 10, 2023

"BETing on Reprogramming Stress"

Kejin Hu, MPhil, Ph.D.
Associate Professor, Department of Biochemistry and Molecular Genetics
The University of Alabama at Birmingham

Friday, Feb 3, 2023

"Cardiogenomics: The Role of Medical Genetics in Evaluating Cardiovascular Disorders in Adults"

Ali Said Al-Beshri, MD
Assistant Professor, Department of Genetics
The University of Alabama at Birmingham

Friday, Jan 27, 2023

"Molecular Diagnosis for Neurofibromatosis: Past, Present and Future"

Yulong Fu, Ph.D., FACMG
Assistant Professor, Department of Pathology
Director, Medical Genomics Laboratory, Department of Genetics (UAB)

Friday, Jan 20, 2023

"Reshaping the Tumor-immune Landscape via Oncolytic Virotherapy"

Jianmei Leavenworth, MD, Ph.D.
Associate Professor, Department of Neurosurgery
Department of Microbiology
University of Alabama at Birmingham

Friday, Jan 13, 2023

"Clinical Genetics in the Genomics Era: Medical Practice & Education"

Nathaniel H. Robin, MD
Professor and Director, Clinical Services
Department of Genetics

Friday, Dec 16, 2022

"Deciphering Host-microbial Functional Interactions Toward Effective Therapies and Symbiotics"

Tatiana T. Marquez Lago, Ph.D.
Associate Professor, Department of Genetics
School of Medicine (UAB)

Friday, Dec 9, 2022

"The Chromatin Remodeler HELLS: A New Regulator in DNA Repair, Genome Maintenance, and Cancer"

Wioletta Czaja, Ph.D.
Assistant Professor, Department of Genetics
O'Neal Comprehensive Cancer Center
School of Medicine (UAB)

Friday, Nov 18, 2022

"AR Variant Biogenesis, PARP Inhibitor Sensitivity and Tumor Immunity in CDK12-Mutated Prostate Cancer"

Haokie Huang, Ph.D.
Professor, Director of Basic Urologic Research, Co-Director of the Genitourinary Cancer Program
Professor of Biochemistry and Molecular Biology and Urology, Mayo Clinic

Friday, Nov 11, 2022

"The All of Us Research Program" 

Bruce R. Korf, M.D., Ph.D.
Department of Genetics
Wayne H. and Sara Crews Finley Endowed Chair in Medical Genetics
Associate Dean for Genomic Medicine, UAB Heersink School of Medicine
Chief Genomics Officer, UAB Medicine

Friday, Nov 4, 2022

"Correlation Between DNA Methylation Patterns, Gene Expression, and Human Heart Failure Etiologies"

Adam R. Wende, Ph.D.
Associate Professor, Department of Pathology
Molecular and Cellular Pathology (UAB)

Friday, Oct 28, 2022

"Redox Regulation by Tryptophan Metabolism: An Emerging Mechanism for Adaptive Immunomodulatory Signaling"

Dario A. Vitturi, Ph.D.
Assistant Professor, Molecular and Cellular Pathology (UAB)

Friday, Oct 21, 2022

"Targeting PI3K/AKT/PTEN Pathway in Cancer" 

Jia Xu, Ph.D.
Assistant Professor, Department of Genetics (UAB)

Friday, Oct 14, 2022

"Optimizing Metabolomic Detection of Aromatic Amino Acid Decarboxylase (AADC) Deficiency, A Rare (But Likely Underdiagnosed) Disorder of Neurotransmitter Metabolism"

J. Daniel Sharer, Ph.D.
Professor and Interim Director, Research
Department of Genetics (UAB)

Friday, Oct 7, 2022

"Interleukin-17 and Prostate Cancer"

Zongbing You, M.D., Ph.D
Professor, Department of Structural and Cellular Biology
Tulane University School of Medicine

Friday, Sept 30, 2022

"Cellular Heterogeneity in Therapeutic Resistance and Disease Progression of Prostate Cancer"

Jiaoti Huang, M.D.
Professor and Chairman, Department of Pathology
Duke University Medical Center

Friday, Sept 16, 2022

"Proteogenomics Opens New Frontiers in Cancer Systems Biology"

Chen Huang, Ph.D.
Assistant Professor, Genetics Research Division (UAB)

Friday, Sept 9, 2022

"TUBB4A Function and Mediated Signaling in Prostate Cancer"

Lizhong Wang, M.D., Ph.D.
Associate Scientist, Comprehensive Neuroscience Center
General Clinical Research Center (UAB)

Friday, Sept. 3, 2021

“Genetic Testing of Neurofibromatosis” 
Juan Dong, PhD
Associate Professor, Department of Genetics
Director, Medical Genomics Laboratory

Friday, Sept. 3, 2021

“Mitochondria in Health and Disease”
Keshav K Singh, Ph.D.
Joy and Bill Harbert Endowed Chair in Cancer Genetics
Professor of Genetics, Pathology and Environmental Health

Friday, Aug. 27, 2021

“Patient Specific Neurofibromatosis Type 1 Animal Models: Translational Studies and Therapeutic Approaches”
Robert Kesterson, Ph.D.
Professor with Tenure
Department of Genetics
University of Alabama at Birmingham

Friday, Aug. 20, 2021

“Genetic and Epigenetic Regulation of Heart Development”
Kai Jiao, MD, PhD 
Professor and Interim Director, Research 
Department of Genetics

Friday, July 23, 2021

“DNA replication initiation and genome instability” 
Anindya Dutta M.D., Ph.D.
Professor/Chairman, Department of Genetics at UAB 

Friday, July 16, 2021

“Microbiome, metabolome, multi-omics…hype or path to precision biomedicine?”
Tatiana T. Marquez Lago, Ph.D.
Associate Professor
Department of Genetics

Friday, July 9, 2021

“Genomic tools for third-generation sequencing data analysis” 
Zechen Chong, Ph.D. 
Assistant Professor, Genetics and Informatics Institute at UAB 

Friday, July 2, 2021

“Using CRISPR to Create Precision Animal Models” 
Laura J. Lambert, Ph.D. 
Assistant Professor, Department of Genetics 

Friday, May 21

“Protein monoaminylation in brain: novel mechanisms of neural development, plasticity and disease” 
Ian S. Maze, Ph.D. 
Associate Professor 
Friedman Brain Institute, Nash Family Department of Neuroscience 
Icahn School of Medicine at Mount Sinai in New York City 

Friday, May 14

“Novel Mechanisms of Oncogenesis and Metastasis”
Mick D. Edmonds, MS, Ph.D.
Assistant Professor
UAB Department of Genetics

Friday, May 7

“Phenomic Modeling”
John Hartman, M.D.
Associate Professor, Department of Genetics

Friday, April 23

“Direct Cardiac Reprogramming: How to Create New Cardiomyocytes?”
Yang Zhou, Ph.D.
Assistant Professor
UAB Department of Biomedical Engineering

Friday, March 5

“Investigating Key Genetic Regulators in Small Cell Lung Cancer”
Michael Kareta, Ph.D. 
Associate Scientist 
Sanford Research, Sioux Falls, SD

Friday, January 15

“Pathophysiological Basis and Mitigation for Cardiometabolic and Genetic Disorders” 
Girish C. Melkani, Ph.D. 
Associate Professor 
Department of Pathology. Division of Molecular and Cellular Pathology 
University of Alabama at Birmingham 

Friday, December 11

“Epithelial FOXP3-regulated network and targeted cancer therapies” 
Lizhong Wang, Ph.D. 
Associate Professor 
UAB Department of Genetics

Friday, November 20

“Feasibility and Potential Impact of Exon Skipping as a Therapeutic for Neurofibromatosis Type I (NF1)” 
Deeann Wallis, Ph.D. 
Associate Professor
UAB Department of Genetics 

Friday, November 6

“Sifting through Data from Clinical Genomes - When is a Case 'Solved'?” 
Elaine Lyon, Ph.D. 
Research Faculty Investigator, HudsonAlpha 
Huntsville, Alabama

Friday, Oct. 23

“Mitochondria Based Priming of Stem Cell Self-Renewal: From Basic Science to its Translation” 
Kasturi Mitra, Ph.D. 
Assistant Professor. Department of Genetics 
Co-Director, GGSC Undergraduate Program 

Friday, Oct. 16

“UAB Genomic Medicine” 
Bruce R. Korf, M.D., Ph.D. 
Wayne H. and Sara Crews Finley Endowed Chair in Medical Genetics 
Associate Dean for Genomic Medicine, UAB School of Medicine 
Chief Genomics Officer, UAB Medicine 

Friday, February 28 | “Understanding and Targeting Glioblastoma Environmental Effects: A Focus on Glucose Transporters” | Anita Hjelmeland, Ph.D., Associate Professor, Department of Cell, Development and Integrative Biology, University of Alabama at Birmingham 

Friday, December 13 | “Targeting α2AAR: Solution for Alzheimer’s Disease” | Qin Wang, Ph.D., Professor, Department of Cell, Developmental and Integrative Biology, UAB

Friday, December 6 | “Bioactive Retinoic Acid: Gene knockouts reveal unexpected roles” | Natalia Y. Kedishvili, Ph.D., Professor, Department of Biochemistry and Molecular Genetics, UAB

Friday, November 22 | “Selective RANK Signaling Pathways as Novel Drug Targets for Breast Cancer Prevention” | Xu Feng, Ph.D., Professor, Department of Pathology 

Friday, November 15 |“Population Genetics in an era of Precision Medicine” | Eimear Kenny, Ph.D., Director, Center for Genomic Health, Associate Professor of Medicine, Associate Professor of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai 

Friday, November 8 | “The identification and targeting of novel oncogenic ncRNA in human cancer” | Mick Edmonds, Ph.D., Assistant Professor, Genetics Research Division, Department of Genetics, UAB

Friday, November 1 | "Computational Drug Repositioning Strategies for Precision Medicine 2.0" | Jake Chen, Ph.D., Chief Bioinformatics Office, Professor, Department of Genetics, Informatics Institute, UAB

Friday, October 25 | “Mathematical modeling: Aiding biomedical discoveries" | Andre Leier, Ph.D., Assistant Professor, Department of Genetics, Assistant Professor, Department of Cell, Developmental and Integrative Biology, Associate Scientist, O’Neal Comprehensive Cancer Center, Member, Gregory Fleming James Cystic Fibrosis Research Center 

Friday, October 18 | “Clinical Application of Genome Sequencing: The Children’s of Alabama Experience” | Anna C.E. Hurst, M.D., MS, FACMG, Assistant Professor,Department of Genetics,UAB

Friday, September 27 | “Fluid-Mosaic Membrane in Aging, Disease and Mitochondrial Function and The use of Membrane Lipid Replacement to Reduce Fatigue, Pain and Other symptoms while Improving Mitochondrial Function” | Garth Nicolson, Ph.D., M.D., Professor Emeritus, President and Founder, The Institute for Molecular Medicine, Huntington Beach, CA

Friday, September 13 | “From Genetic to Pharmacological Inhibition of TXNIP- Effects on Diabetes” | Anath Shalev, M.D., Professor of Medicine - Endocrinology, Diabetes & Metabolism, Nancy R. and Eugene C. Gwaltney Family Endowed Chair in Juvenile Diabetes Research, Director, UAB Comprehensive Diabetes Center 

Friday, September 6 | “Genetic and epigenetic regulation of Duchenne muscular dystrophy” | Matthew S. Alexander, Ph.D., Assistant Professor, UAB Pediatric Neurology

Friday, May 17 | “Implementation of a Personalized Medicine Program Across a Community Health System” | Peter J. Hulick, M.D., MMSc, FACMG, Medical Director, Mark R. Neaman Center for Personalized Medicine Division, Head, Center for Medical Genetics NorthShore University HealthSystem, Clinical Assistant Professor, University of Chicago, Pritzker School of Medicine

Friday, May 10 | “STAT3: From Fundamental Discoveries to Novel Targeting Platforms” | Hua Yu, Ph.D., Billy and Audrey L. Wilder Professor in Tumor Immunotherapy, Associate Chair and Professor, Department of Immuno-Oncology, Co-leader, Cancer Immunotherapeutics Program, City of Hope Comprehensive Cancer Center

Friday, May 3 | “InterGenomic Cross Talk Underlying Aging and Cancer” | Keshav K. Singh, Ph.D., Joy and Bill Harbert Endowed Chair in Cancer Genetics and professor, Department of Genetics University of Alabama at Birmingham

Friday, April 19 | “Enhancing Precision Oncology at UAB” | Eddy S. Yang, M.D., Ph.D., Professor, Vice Chair for Translational Science, Department of Radiation Oncology, University of Alabama at Birmingham

Friday, April 12 | “Genetics and Epigenetic Regulation of Heart Development in Mice” | Kai Jiao, M.D., Ph.D., Associate Professor, Department of Genetics, Genetics Research Division, University of Alabama at Birmingham

Friday, March 22 | “The Impact of Geometry, Diffusion Barriers and Stochasticity in Cell Polarity and Protein Dynamics” | Tatiana Marquez-Lago, Ph.D., Associate Professor, Department of Genetics, Research Division, University of Alabama at Birmingham

Friday, March 15 | “Functional characterization of human disease-associated gene variants using the vertebrate animal model Xenopus laevis” | Chenbei Chang, Ph.D., Professor, Department of Cell, Developmental and Integrative Biology, UAB

Friday, March 8 | “RAS and the Plasma Membrane: A Complicated Relationship” | John Hancock, MA MB BChir PhD ScD MRCP FRACP, Professor and Chairman, Department of Integrative Biology and Pharmacology, Executive Director, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center

Friday, February 22 | “Epithelial Homeostasis in Development and Disease” | Ian G. Macara, PhD, Professor and Louise B. McGavock Chair, Department of Cell and Development Biology, Vanderbilt University Medical Center

Friday, February 15 | “Structural Variations of the Immunoglobulin Receptors and
Clinical Phenotype” | Robert P. Kimberly, M.D., Director, Center for Clinical and Translational Science University of Alabama at Birmingham

Friday, February 1 | “A Novel Technology Developed at UAB for Phenomic Research and Drug Discovery” | John L. Hartman IV, M.D., Associate Professor, UAB Department of Genetics

Friday, January 18 | "Polycystic Kidney Disease-Treatment Options Update" | Michal Mrug, M.D., Professor of Medicine, Department of Nephrology

Friday, January 11 | “The algorithm for precision medicine” | Matthew Might, Ph.D., Professor of Computer Science, Director, UAB’s Hugh Kaul Precision Medicine institute, University of Alabama at Birmingham

Friday, December 14 | “Molecular profiling in ovarian cancer” | Rebecca C. Arend, M.D., Assistant Professor, Department of Obstetrics and Gynecology, University of Alabama at Birmingham

Friday, December 7 | “Epithelial-mesenchymal Transition in Breast Cancer Progression and Metastasis” | Binhua (Peter) Zhou, M.D., Ph.D., Co-Director, Center of Biomedical Research Excellence in Cancer and Metabolism, University of Kentucky, Lexington, KY

Friday, November 30 | "A Mitochondrial Etiology of Common 'Complex' Diseases" | Douglass C. Wallace, Ph.D., Professor, Department of Pathology and Laboratory Medicine, University of Pennsylvania 

Monday, November 19 | "Design and evolution of trans-splicing group I intron ribozymes" | Ulrich F. Muller, Ph.D., Associate Professor, Department of Chemistry and Biochemistry, University of California at San Diego

Friday, November 2 | “Unraveling the complex roles of SIN3 in breast cancer metastasis”| Douglas R. Hurst, Ph.D., Assistant Professor, Department of Pathology, University of Alabama at Birmingham

Friday, October 19 | "Patient-Specific NF1 Rodent Models & Gene Correction Therapies" | Robert A. Kesterson, Ph.D., Professor, Department of Genetics, UAB

Friday, October 12 | "The ELMOD family of ARF family GAPs: roles in mitochondria, cell cycle, ciliogenesis, and transcriptional regulation" | Richard A. Kahn, Ph.D., Professor, Department of Biochemistry, Emory University

March 9, 2018 | Phillip Owens, Ph.D. | University of Colorado

March 16, 2018 | Richard Finnell, Ph.D. | Baylor College of Medicine

March 23, 2018 | Anthony Wynshaw-Boris, M.D., Ph.D. | Case Univeristy

April 4, 2018 | Nita Limdi, PharmD, Ph.D. | UAB

April 13, 2018 | Chulan Kwon, MS, Ph.D. | John Hopkins University

April 20, 2018 | Merry-Lynn McDonald, Ph.D. | University of Alabama at Birmingham 

May 4, 2018 | Mikhail Alexeyev, Ph.D., I University of South Alabama

May 11, 2018 | Jiangbing Zhou, Ph.D. I  Yale University