• Di Stasi AD PIC 2015 webRank:                   
    Assistant Professor                                   
    Blood and Marrow Transplantation and Cell Therarpy Program


    Website:
    https://www.uab.edu/medicine/bonemarrow/

    Division:              
    Hematology & Oncology

    Campus Address:

    WTI 520


    Mailing Address: 
    1720 2nd Avenue South, WTI 5
    Birmingham, AL 35294-3300

    Administrative Contact:  
    Gloria Owens
    gowens@uabmc.edu
    (205) 975-3371

    For an appointment, call (205) 934-9999 or toll free 1 (800) UAB-8816.

        
    Departmental Affiliation(s):

    Primary: Medicine

    Education
    Medical School:   
    University of Modena and Reggio Emilia, Modena, Italy    

    Internal Medicine Residency:
    University of Milan, Milan, Italy.

            
    Fellowships:       
    Medical Oncology and Bone Marrow Transplantation, University of Milan, Milan, Italy

    Bone Marrow Transplantation Fellowship, MD Anderson Cancer Center, Houston, TX
                                                   

    Other Education:
    Post doctoral fellow, Center for Cell and Gene Therapy,

    Baylor College of Medicine, Houston, TX

    Certifications:
    Board certified by Italian Board of Internal Medicine (and Medical Oncology).


    Biosketch:
    Dr. Di Stasi received his M.D. degree from the University of Modena in Italy. He did his internal medicine and medical oncology training at the university of Milan, in Italy, where he trained in particular in the management of hematologic malignancies and hematopoietic stem cell transplantation. Following his fellowship he joined the Center for Cell and Gene Therapy (Baylor College of Medicine, Houston, TX) for post-doctoral studies, where he completed the pre-clinical validation of an immunotherapy protocol for the treatment of relapsed Hodgkin lymphoma, and the clinical validation of a novel suicide gene safety switch for graft-versus-host-disease occuring after donor lymphocyte infusion. Afterwards, he underwent ECFMG certification and moved to the University of Texas MD Anderson Cancer Center for Bone Marrow Transplantation fellowship and clinical research, especially regarding myelodisplastic syndromes, acute myeloid leukemia, and haploidentical hematopoietic stem cell transplantation.

    His work has been published in high-impact journals such as Blood, and The New England Journal of Medicine. In addition, he has authored four book chapters and has lectured in the US and Europe.

                                                                    

    Publications:
    See a listing of publications on PubMed, a service of the National Library of Medicine.

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  • Rank:Professor Randall-Davis-Cropped-LR 2

    Division
    :

    Hematology & Oncology

    Departmental Affiliation(s):
    Primary: Medicine
    Secondary: Microbiology
    Secondary: Biochemistry & Molecular Genetics

    Campus Address
    :
    SHEL 413, Zip 2182 


    Mailing Address:                                                            
    1720 2nd Avenue South, SHEL 413        
    Birmingham, AL 35294-2182

    Clinic Phone: (205) 801-8415
    Office Phone:
    (205) 934-2992


    Email: rsdavis@uab.edu

    UASOM:Faculty Profile

    For an appointment, call (205) 934-9999 or toll free 1 (800) UAB-8816.


    BIOSKETCH

    A graduate of Boston University in Boston, Massachusetts, Dr. Davis completed medical school at the University of Alabama School of Medicine (UASOM), where he also served his internship, residency, and the ABIM academic subspecialty research fellowship clinical investigator pathway in Hematology/Oncology. He is Professor of Medicine, Microbiology, and Biochemistry and Molecular Genetics in the division of Hematology/Oncology. He is board certified in Hematology.

    Clinical Interests:
    Dr. Davis' clinical expertise is in Hematology/Oncology with a specific focus on B cell chronic lymphocytic leukemia (CLL) and lymphoproliferatve disorders.

    Board Certification(s):
    Hematology, American Board of Internal Medicine

    Education & Training
    :
    1987 - 1992     B.A., Biology, Boston University
    1992 - 1997     M.D., Medicine, University of Alabama at Birmingham
    1997 - 1998     Intern, Internal Medicine, University of Alabama at Birmingham
    1999 - 2003     Postdoctoral Fellow,  Hematology/Oncology and Immunology, University of Alabama at Birmingham   

    Active Positions:

    Attending Physician, Active Staff, Medicine Service: Hematology/Oncology
    Director, Multidisciplinary Molecular Interaction Core (MMIC)
    Senior Scientist, UAB Comprehensive Cancer Center
    Scientist, UAB Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center
    Member, UAB Center for AIDS Research
    Member, UAB Comprehensive Diabetes Center
    Member, UAB Diabetes Research Center
    Faculty, Graduate Biomedical Sciences - Themes: Cancer Biology, Immunology, and Pathobiology & Molecular Medicine
    Faculty, Medical Scientist Training Program (MSTP) - Research Areas: Cancer Biology, Immunology and Inflammation, and Molecular Genetics & Disease

    Honors:
    UAB Department of Medicine Walter B. Frommeyer, Jr., Fellowship in Investigative Medicine Physician Scientist Award (2000-2001); UAB Department of Medicine J. Claude Bennett Award for Excellence in Research by an Associate Fellow (2001, 2002); Leukemia and Lymphoma Society Special Fellow Career Development Award (2003); NIH-NIAID K08 Mentored Clinical Scientist Development Award (2003); Dana Foundation Human Immunology Program Award (2005); V Foundation for Cancer Research Scholar Award (2005); Member, Henry Kunkel Society (2006); Cancer Research Institute Investigator Award (2006); American Cancer Society Research Scholar Award (2008); CLL Global Research Foundation Award (2008); Member, Southern Society for Clinical Investigation (2012); Lupus Research Institute Novel Research Grant Award (2013).

    Professional Memberships:
    American Association of Immunologists (AAI)
    American Society of Hematology (ASH)
    Henry Kunkel Society
    Southern Society for Clinical Investigation (SSCI)

    Research Interests:
    Dr. Davis' laboratory is focused on the cellular and molecular immunobiology of lymphocytes in normal and diseased conditions. He has been broadly trained as a physician-scientist with a background in basic lymphocyte development and receptor biology. As a postdoctoral fellow he co-discovered a multigene family that encodes Fc receptor-like (FCRL) molecules with tyrosine-based regulatory potential that are expressed by subpopulations of lymphocytes in normal and diseased states. Current work involves investigating FCRL members in humans and mice to define their functional roles in normal and aberrant immune conditions. Work by his group and through productive collaborations has provided a better understanding of these receptors in basic immunology as well as in clinically important autoimmune and malignant conditions. Beyond his role as a physician-scientist, he also serves as Director of the UAB Multidisciplinary Molecular Interaction (MMIC) Core Facilitywhich supports the operation of a Biacore T200 instrument. This technology allows for the determination of very sensitive kinetic interactions between macromolecules and/or small drugs using surface plasmon resonance (SPR).



    Selected Publications

    1. Davis, R.S., Wang, Y., Kubagawa, H., and M.D. Cooper: Identification of a Family of Fc Receptor Homologs with Preferential B Cell Expression. (2001) Proc. Natl Acad. Sci., 98: 9772-9777. PMCID: PMC55528

    2. Ehrhardt, G. R. A., Davis, R.S., Hsu, J.T., Leu, C-M., Ehrhardt, A., and Cooper, M.D. The inhibitory potential of FcRH4 on memory B cells. (2003) Proc. Natl. Acad. Sci. USA100:13489-13494. PMCID: PMC263841.

    3. Davis, R.S., Stephan, R.P., Chen, C.-C., Dennis, G. Jr. and Cooper, M. D. Differential B Cell Expression of Mouse Fc Receptor Homologs. (2004) Int. Immunol. 16:1343-1353. PMID: 15302849.

    4. Leu, C-M., Davis, R.S., Gartland, L.A., Fine, D.F., and Cooper, M.D. FcRH1: an activation co-receptor on human B cells. (2005) Blood 105:1121-1126. PMID: 15479727.

    5. Ehrhardt, G. R. A., Hsu, J.T., Gartland, L, Leu, C-M, Zhang, S., Davis, R.S. and Cooper, M.D. Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells. (2005) J Exp Med 202: 783-791. PMCID: PMC2212938.

    6. Won, W-J.,Foote, J.B., Odom, M., Pan, J., Kearney, J.F., and Davis, R.S.FcRH3 Is a Novel Immunoregulatory Marker of Marginal Zone and B1 B cells. (2006) J. Immunol. 177:6815-23. PMID: 17082595

    7. Davis, R.S. Fc Receptor Homologs. (2007) Ann. Rev. Immunol. 25:525-60. PMID: 17201682

    8. Hirano, M., Davis, R.S., Fine, W.D., Nakamura, S., Shimizu, K., Yagi, H., Kato, K., Stephan, R.P., Cooper M.D. IgEb immune complexes activate macrophages through FcgammaRIV binding. (2007) Nat Immunol. Jul;8(7):762-71. Epub 2007 Jun 10. PubMed PMID: 17558411.

    9. Li, F.J., Ding, S., Pan, J., Shakhmatov, M.A., Kashentseva, E., Wu, J., Li, Y.F., Soong, S.J., Chiorazzi, N., and Davis, R.S. FCRL2 expression predicts IgVH mutation status and clinical progression in chronic lymphocytic leukemia. (2008) Blood 112:179-87.PMCID: PMC2435687. 

    10. Gibson, A.W., Li, F.J., Wu, J., Edberg, J.C., Su, K., Cafardi, J., Wiener, H., Tiwari, H., Kimberly, R.P., and Davis, R.S. The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells. (2009) Arthritis Rheum 60:3510-2. PMCID: PMC2784265

    11. Schreeder, D. M., Cannon, J. P., Wu, J., Li, R., Shakhmatov, M. A., and Davis, R. S.Cutting Edge:FCRL6 is an MHC class II receptor. (2010) J. Immunol, 185:23-7. PMID: 20519654

    12. Campbell, J.A., Davis, R.S., Lilly, L.M., Fremont, D.H., French, A.R., and Carayannopoulos, L.N. Cutting Edge: FCRL5 on Innate B Cells is Targeted by a Poxvirus MHC Class I-like Immunoevasin. (2010) J. Immunol, 185:28-32. PMCID: PMC3321838

    13. Sohn, H. W., Krueger, P. D., Davis, R.S., and S. K. Pierce. The Potential of FCRL4 to Function as an Adaptive to Innate Molecular Switch in Exhausted Memory B Cells. (2011) Blood. 118:6332-41. PMCID: PMC3236118

    14. Zhu, Z., Li, R., Li, H., Zhou, T., and Davis, R.S. FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. (2013) Proc. Natl. Acad. Sci. USA.110:E1282-90. PMCID: PMC3619311

    15. Li FJ, Schreeder DM, Li R, Wu J, Davis RS. FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation.  (2013) Eur J Immunol. Nov;43(11):2980-92. 10.1002/eji:201243068. Epub 2013 Aug 12. PubMed PMID: 23857366; PubMed Central PMCID: PMC3838486.

    Additional Publications:See a complete listing of publications on PubMed, a service of the National Library of Medicine.

    Postdoc Positions Available

    A postdoctoral position is available in the laboratory of Dr. Randall Davis to investigate pathways of lymphocyte development and function of a novel family of Fc receptor-like molecules (FCRL). Studies involve establishing human and mouse disease models, exploring signaling potential and gene regulation. M.D. and/or Ph.D. is required. Please send curriculum vitae and names of three references to: Randall S. Davis, M.D. 1720 2nd Avenue South, SHEL 402, Birmingham, AL 35294-2182 or via email to rsdavis@uab.edu.


    We have a very interactive group comprised of graduate students, medical residents, postdoctoral fellows, and research associates.


    To search for Student Research Opportunities at UAB, gohere

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  • Ravi Bhatia 2014Rank:  
    Professor of Medicine
    Division Director, Hematology/Oncology
    Deputy Director, UAB Comprehensive Cancer Center
     
    Division:            
    Hematology & Oncology

    Campus Address:   
    NP 2555


    Mailing Address:
       
    1720 2nd Avenue South, NP2540
    Birmingham, AL 35294-3300

    Administrative Contact:
    Sherron Thornton
    sthorn@uabmc.edu
    (205) 934-9591

    For an appointment,call (205) 934-9999 or toll free 1 (800) UAB-8816.

    Departmental Affiliation(s):
    Primary: Medicine

    Medical School:
    All India Institute of Medical Sciences, New Delhi, India

    Internal Medicine Residency:
    All India Institute of Medical Sciences, New Delhi, India

    Fellowship:
    Fellowship in Hematology/Oncology from University of Minnesota, Minneapolis


    Awards and Honors:
    Stohlman Scholar of the Leukemia and Lymphoma Society
    Elected, American Society of Clinical Investigation, 2006
    Leukemia and Lymphoma Society, Scholar in Clinical Research Award, 2002
    NIH FIRST Award, 1996
    Watson Award-University of Minnesota, 1996
    American Society of Clinical Oncology, Young Investigator Award, 1995
    Frank Trobough Award of the American Federation for Clinical Research, 1991

    MB BS:
    Institute Gold Medal for the best graduate of the year, 1983
    First position in the first and second professional examinations
    Katherine Sorel Prize for the best student in Pediatrics
    Sardari Lal Kalra Gold Medal for the best student in Microbiology
    First position in Anatomy, Pathology and Microbiology
    Forensic Medicine and Internal Medicine


    Biosketch:
    Positions and Employment:
    May 2005 – December 2014
    Professor
    Director, Division of Hematopoietic Stem Cell and Leukemia Research
    Co-Director, Hematological Malignancies Program, City of Hope Comprehensive Cancer Center
    Department of Hematology/HCT
    City of Hope National Medical Center
    Duarte, CA

    April 2004 – May 2005
    Associate Professor
    Department of Hematology/HCT
    City of Hope National Medical Center
    Duarte, CA

    September 1996 – April 2004
    Assistant Physician (equivalent to Assistant Professor)
    Department of Hematology/HCT
    City of Hope National Medical Center
    Duarte, CA

    September 1995 – August 1996
    Clinical Assistant Professor
    Division of Hematology
    Department of Medicine
    University of Minnesota


    Major Research Interests

    My research goals are to develop an improved understanding of abnormal regulation of malignant stem and progenitor cells in hematologic malignancies and to develop effective approaches to eliminate these cells to enhance outcomes for these cancers. In addition to being a practicing clinical Hematologist-Oncologist and Hematopoietic Cell Transplant physician, I have extensive experience in studying normal and malignant hematopoietic stem cell regulation in the translational laboratory setting. During my fellowship at the University of Minnesota, under the mentorship of Dr. Catherine Verfaillie and Dr. Philip McGlave, I studied mechanisms of microenvironmental regulation of normal and malignant hematopoiesis, and mechanisms of response and resistance of leukemia stem cells to therapy. After establishing my independent research program at City of Hope, I have continued to investigate mechanisms of regulation of normal and leukemia stem cell growth and therapeutic targeting of leukemia stem cells. My research goals are to develop an improved understanding of abnormal regulation of malignant stem and progenitor cells in hematologic malignancies and to develop effective approaches to eliminate these cells to enhance outcomes for these cancers. I was appointed as Director of the Division of Hematopoietic Stem Cell and Leukemia Research and co-Director of the Hematological Malignancies Program in the Comprehensive Cancer Center in 2006 to develop a basic and translational program in hematological malignancies and hematopoietic stem cells at our center. Since taking over this position, I have recruited and mentored an outstanding group of young faculty with a common interest in investigating mechanisms of regulation of normal stem cell growth; cellular and molecular mechanisms underlying hematopoietic cell transformation in patients with hematological malignancies; identification of critical therapeutic targets; and preclinical and clinical development of innovative, mechanism-based therapeutic interventions.


    Research Description

    Mechanisms of transformation and maintenance of leukemia stem cells
    Therapeutic targeting of leukemia stem cells


    Publications: See a listing of publications on PubMed, a service of the National Library of Medicine.

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