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UAB Medicine is one of the top academic medical centers in the United States and Alabama's largest single-site employer. Anchored by UAB Hospital, the center's ambulatory care facilities, VA Medical Center, and Children's Hospital of Alabama are located within easy walking distance of each other, and many pathways are connected by sky bridges for easy access.

UAB Medicine has been named one of U.S. News & World Report's Best Hospitals, the Number 1 Best Large Employer for 2021 by Forbes magazine and is listed among the 150 Top Places to Work in Healthcare by Becker's Hospital Review.

UAB Medicine was also designated a Health Care Equality Leader by the Human Rights Campaign Foundation for demonstrating leadership in LGBTQ health care and employment.