We cordially invite you to participate in "Glycoimmunobiology 2013", a full day workshop / minisymposium to be held at UAB on November 22, 2013.
Glycans are important components of glycoproteins, including immunoglobulins and glycoproteins on the surface of cells of the immune system. These sugar components are not only important structural features, but in many instances modulate or mediate a wide variety of functions in physiological as well as pathophysiological situations.
Notably, glycosylation of glycoproteins is altered in multiple human diseases, including chronic inflammatory and autoimmune diseases (rheumatoid arthritis, inflammatory bowl disease, Crohn's disease, IgA nephropathy), infectious diseases (tuberculosis, HIV), and many types of cancer (breast cancer and other adenocarcinomas). Moreover, many viruses including HIV and HCV present surface structures that are glycosylated and it has been shown that such structures act both as a shield from the immune system as well as an immunogenic material possibly usable for vaccine development.
Understanding of glycosylation of glycoproteins in health and disease, including mechanisms and dynamics of glycosylation changes and regulatory pathways, will offer not only better tools for diagnostic purposes but also will generate knowledge for future glycan-targeting intervention. These issues were recently recognized by the National Research Council in their August 2012 report "Transforming Glycoscience: A Roadmap to the Future."
This workshop/minisymposium will provide an overview of the current "state of the art" as well as a forum to discuss outlook for interdisciplinary studies to elucidate the role of glycosylation in various aspects of immune system in health and disease.
We are looking forward to welcoming you at the workshop.
|Jan Novak, PhD
Professor, UAB Department of Microbiology
|Susan L. Bellis, PhD
Professor, UAB Department of Cell,
Developmental and Integrative Biology
|Matthew Renfrow, PhD
Assistant Professor, UAB Department of Biochemistry
and Molecular Genetics, Director of Biomedical FT-ICR
Mass Spectrometry Laboratory