Seminar Series 2018-2019 - School of Medicine - Microbiology | UAB

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Department of Microbiology

School of Medicine

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SEPTEMBER
Date	Name	Institution	Host	Area of Interest/Recent Publications	Title
9/4/18	Andries Steyn	UAB, Microbiology	Joel Glasgow	Understand the mechanisms of M. tuberculosis virulence	Translational Research for Tuberculosis Elimination in Durban, South Africa: 3D Imaging, Lung Architecture and Basic Science
9/11/18	Susan Bellis	UAB, CDIB	Allan Zajac	role of ras-directed integrin sialyayion in tumorigenesis/metastasis. Hyposialyation of b1 integrins the increased adhesiveness of differentiated monocytic cells. Integrin-mediated adheision of osteoblasts to implant materials.	Novel role for glycans in imparting stem-like cancer cell characteristics that promote tumor initiation and progression
9/18/18	Haitao Guo	Indiana Univ	George Luo	viral pathogenesis of hepatitis B virus and antiviral discovery	HBV cccDNA: How It's Made?
9/25/18	Elina Zuniga	Univ of Cal San Diego	Allan Zajac	Studies cellular and molecular aspects of immune responses during acute and chronic viral infections to determine general principals of antiviral immunity, immune-evasion, persistence and pathogenesis	Immune Adatations During Chronic Viral Infections

OCTOBER
Date	Name	Institution	Host	Area of Interest/Recent Publications	Title
10/2/18	Jeffrey Bluestone	Univ of Cal San Fran	Rachel Jimenez	T cell activation and immune tolerance in autoimmunity & organ transplantation. Adapted the animal studies using biologics and cell based therapies to develop therapeutics that can be used in humans with autoimmunity & under conditions of allotransplant rejection	Treg biology to understand and treat disease
10/9/18	Robert Davey	Boston University	Ilya Frolov	identificaation of cellular factors important for establishing infection by filovirus and bunyaviruses, also developed high throughput screening techniques of Ebloavirus	Understanding macropinocytosis through the lens of Ebloa virus
10/16/18	Jens Wrammert	Emory Vaccine Center	Rodney King	Understanding of human and macaque B cell responses following infection (dengue, cholera) or vaccination (influenza and SHIV/HIV)	Single Cell Analyses of Human B Cell Responses
10/18/18	Ivaylo Ivanov	Columbia University	Fran Lund	identifying specific examples of immunomodualry ineractions between commensals and host as well as the underlying mechanisms	Research Overview
10/22/18	James Driscoll	University of Cincinnati	Special Seminar	development of practical, clinically-relevant strategies to overcome drug resistanct in cancers	Proeasome Function in Healthy and Disease States
10/23/18	No Microbiology Seminar this week
10/24/18	Botond Igyártó	Baylor University	Special Seminar at 10am in BBRB 170	Role of different dendritic cell ( DC) subsets in induction of humoral immune responses, generation of DC-vaccines targetting different cancers, Neuro-dendritic cell interactions, in vivo re-prgramming of DCs for therapeutic purposes	"Dendritic Cell Biology - Born to Regulate and Be Regulated"
10/29/18	Henry Wan	Mississippi State University	Special Seminar	host-pathogen interactions and the environment-pathogeninteractins using intergrativ approaches, such as molecular biology, ecll biology, animalmodels, computation modeling, machine learning, evolutionary biology, epidemiolgy, genomics, and glycoproteomics approaches	"Seasonal Influenza Vaccine: not easy shot to get"
10/30/18

NOVEMBER
Date	Name	Institution	Host	Area of Interest/Recent Publications	Title
11/6/18
11/13/18	Susana Valente	Scripps Research Institute	Jamil Saad / CFAR	Discovery and characterization of molecular interactions occurring within a host cell that are critical for HIV replication - identified interactions can be tailored to develop therapeutic targets and provide novel antiviral approaches	"Silencing the HIV-1 reservoir"
11/20/18	Thanksgiving wk	No seminar held
11/27/18	Asma Hatoum-Aslan	Univ of AL	Michael Gray	uses tools of biochemistry and molecular genetics to unravel the mechanisms of small RNA-mediated pathways and enable the development of novel and anti-microbial therapeutics	"CRISPR-Cas10 immunity in staphylococci: Mechanisms and applications"

DECEMBER
Date	Name	Institution	Host	Area of Interest/Recent Publications	Title
12/4/18	Li Wu	The Ohio State University	Virology faculty recruit	molecular mechanisms of HIV replication and retorviral pathogeneisis, cel-toell HIV-1 transmission and HIV-1 restriction on primary myeloid cells	"How does the host protien SAMHD1 restrict HIV-1 infection and antiviral immunity?"
12/5/18	Laurie Krug	Stony Brook University	Virology faculty recruit	molecular determinants of virus-host interactions during chronic infections caused by human gammaherpesviruses: Epstein-Barr virus (EBV) and Kaposi’s sarcoma associated-herpesvirus (KSHV)	"Gammaherpesviruses armed to combat uracils: Impact of uracil DNA glycosylase and dUTPase in pathogenesis and genomic stability"
12/11/18	Toru Takimoto	University of Rochester	Virology faculty recruit	molecular mechanisms of paramyxovirus assembly, assembly of influenza A viruses, role of influenza virus polymerase in host adaptation	"Strategies of host adaptation of influenza A viruses"
12/17/18	Jesse Erasmus	Infectious Disease Research Institute	Virology faculty recruit	engineering RNA molecules with viral-derived functions provides fundable opportunities to study basciu aspects of virus replication in an application-driven manner with clear pathways to the clinic	" Exploiting virus replication for the development of platform technologies"
12/18/18
12/25/18	Christmas Day	No seminar held

JANUARY
Date	Name	Institution	Host	Area of Interest/Recent Publications	Title
1/1/19	New Year’s Day	No seminar held
1/8/19	Laty Cahoon	University of Illinois, Chicago			"Gram positive secretion: don't leave the cell without a chaperone!"
1/9/19	Carrie Coleman	University of Colorado	Virology Faculty Recruit	understand the mechanisms used by oncogenic gammaherpesviruses, MHV68 and EBV to setablish and maintain a life-long latent infection	"EBV Type 2 infection of T cells: an alternative strategy for viral persistence"
1/14/19	Masakazu Kamata	University of California, Los Angeles	Joint CCC/Microbiology Faculty recruit		"Developing Novel Immunological Cure Strategies for HIV-1 Infection"
1/15/19	Joshua Woodward	University of Washington	Hui Wu	Focused on elucidataing the interactons of bacterial pathogens with their hosts using Listeria monocytogenes. Also interested in interrogating the mechanisms of cytosolic immuno-surveellance as well as the roles of c-di-AMP in bacterial physiology	"Cytosolic RECONnaissance : Host strategies for detecting bacterial cyclic dinucelotides"
1/16/19	Wenhan Zhu	University of Texas, Southwestern Medical Center	Bacteriology Faculty Recruit	molecular interactions that shape the interaction between the host adn the intestinal microbiota in particular when this interaction is perturbed during episodes of intestinal inflammation	"Metabolic interactions in the inflamed intestine"
1/22/19	Arturo Casadevall	John Hopkins Univ	David Chaplin	Understand how hosts defend against Crptococcus neoformans and how its virulence contributes to disease, alos interested in devising antibody-based countermeasures to protect against anthrax	"Thoughts on the origin of virulence"
1/23/19	Sergey Novitskiy	Vanderbilt University	Joint CCC/Microbiology Faculty recruit	dissect interactions of adenosine collaborative work converge tuissue microenvironments, TGFB pathowats and their conjoint impact on inflammation and tunorigenesis	" Role of Adenosine in TGF-beta Effects in Cancers"
1/29/19	Irene Salinas rescheduled to April 16th UAB closed due to weather	Univ. of New Mexico	Jiri Mestecky	Evolution of immune repsonses, mucosal immunity of fish, host-parasite interactions, aqua culture, fish diseases, modulation of fish immune repsonosed by commensal microorganisms ontogeny of fish immune system	"Antiviral neuroimmune interactions at the nasal epithelium of teleost fish"

FEBRUARY
Date	Name	Institution	Host	Area of Interest/Recent Publications	Title
2/4/19	Christina Camell	Yale School of Medicine	Immunology Faculty Recruit	understanding the role of adipose tissue macrophages and how thye survive the tissue to promote tissue homeostasis, and changes that occur with aging and the contribution to age-related metabolic dysfunction	"Tissue resident macrophages drive adipose dysfunction during aging"
2/5/19	Elizabeth Sztul	Univ of Ala, Birmingham	Allan Zajac	molecular mechanisms that regulate the delivery of proteins to their cellualr sites of action, how intracellualr membrane traffic is controlled, devleop technology that will selectively slow down degrative sorting of clinically relevant proteins	"Hijacking hosts transport factors for poliovirus replication"
2/12/19	Ilhem Messaoudi Powers	Univ of Cal Irvine	Louis Justement	viral pathogenesis, host defense, modulation of immunity by nutrition and aging, impact of the microbiome on immunity	"Impact of pregravid obesity on maternal and fetal immunity"
2/19/19	Nichole Broderick	Univ of Conn	Mike Gray	study impacts of beneficial and pathogenic bacteria on host development physiology, and health using a variety of molecular, genetic and genomic approaches using Drosophila melanogaster	"Immunity at the interface of Drosophila-microbiome interactions"
2/26/19	Malcolm Winkler	Indiana Univ Bloomington	Carlos Orihuela Bacterials Path Group	Understand signal transduction, regulatory mechanisms, and suprmolecular complexes that mediate the stress responses, metabolism, cell structure and pathogenesis of S. pneumoniae	" Dynamica and Regulation of Peptidoglycan Cell Wall Synthesis in the Superbug Streptococcus pneumonia"

MARCH
Date	Name	Institution	Host	Area of Interest/Recent Publications	Title
3/5/19	Dr. Angela Wilks had to cancel, will be rescheduled in 2019-2020				"
3/12/19	Marx Lecture: Daniel Littman	NYU School of Medicine	Fran Lund	Microbiota-regulated immunity, epigenetic regulation of T cell differentiation, and mechanisms of retroviral pathogenesis	"Dissecting immune system regulation by commensal microbes"
3/19/19	Troy Randall	UAB, Clinical Immunology/Rheumatology	Beatriz Leon	how local lymphhoid tissues develop and function in the respiratory tract, understand the development funtion of unusual lymphoid tissues in teh peritoneal and leural cavitiies, how CD40 signaling controls CD8 T cell responses t virese and tumors, local control of autoimmune/inflammatory T and B cell responses	"Pulmonary immunity to influenza"
3/26/19

APRIL
Date	Name	Institution	Host	Area of Interest/Recent Publications	Title
4/2/19	Marc Lipsitch, had to cancel , hopefully will be rescheduled next year	Harvard	David Briles	the effect of naturally acquired host immunity, vaccine-induced immunity and other public health inteverntions (e.g.antimicrobial use) on the population biology of pathogens andthe consequences of changing pathogen populations for human health
4/9/19	Sallie Permar	Duke Univ Medical Center	Mark Walter	focuses on maternal correclates of immune protection against vertical transmission of neontal pathogens	"Next Gerneration Vaccines to Prevent Congenital CMV Infection"
4/16/19	Irene Salinas	Univ. of New Mexico	Jiri Mestecky	Evolution of immune repsonses, mucosal immunity of fish, host-parasite interactions, aqua culture, fish diseases, modulation of fish immune repsonosed by commensal microorganisms ontogeny of fish immune system	"Antiviral neuroimmune interactions at the nasal epithelium of teleost fish"
4/17819	Eric Ubil	Univ. Of North Carolina, Chapel Hill	Microbiology / CCC/ Pathology/ Hem/Onc Faculty recruit	Studying the role of the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases incancer-mediated immune suppression, Discovered that tumors secrete Pros1 (a TAM ligand) and effectively reduce the ability of the innateimmune system to mount an anti-tumor response, Identified the molecular mechanism of tumor-mediated suppression of macrophages	"Enhanced Anti-Cancer Therapy by Targeting the Pros1:Mcarophage Mer Axis"
4/23/19	David Bedwell	UAB, Department of Biochemistry and Molecular Genetics	Charles Turnbough	understand the mechanistic details of translation termination in eukaryotes and use to develope therapeutic stategies for a range of genetic diseases such as cystic fibrosis and lysosomal storage disease	"Suppression of Nonsense Mutations to Treat Genetic Diseases"
4/30/19	Graham Hatfull	University of Pittsburgh	N'toia Hawkins Virology Grad Students	using mycobacteriophages to understand mycobacterial genetics	"Diversity, Defense, and Collusion: The complex dynamics of Actinobacteriophages and their hosts"

MAY
Date	Name	Institution	Host	Area of Interest/Recent Publications	Title
5/7/19	David Wells Memorial Lecturer: Alexander Rudensky	Sloan Kettering Institue	Fran Lund -	understanding moclecular mechanisms governing the differentiation and function of CD4 T lymphocytes and their role in immunity and tolerance	"Many faces of T regulatory T cells"
5/13/19	Henrique Borges da Silva	University of Minnesota	CCC / Microbiology Faculty recruit	understanding how extracellular nucelotides regulate the immune system	"Extracellular ATP sensing mediates CD8 T cell immune repoinses to infection and tumor"
5/21/19	Rebecca Lamason	Massachusetts Institute of Technology	Uday Tak & Ashleigh Riegler	How bacterial pathogens usurp host cell function to gain insights into both host cell biology and pathogenensis	"Bacterial pathogens hijack host machinery to promote cell-to-cell spread"
5/28/19	Linda Hendershot	St. Jude	John Kearney	Control of the synthesis and assembly of secretory proteins in the ER, regulation of immunoglobulin transport, elucidation of ER stress-induced signal transduction pathways, role of the ER stress response in regulating tumor chemosensitivity	"Protein Folding in the ER: life and death decisions for BiP substrates"