Anthony P. Nicholas, M.D., Ph.D. (2)

Nicholas
Associate Professor of Neurology

Professional Background:
M.D., Ph.D., University of Texas Medical Branch, 1990
Email: nicholas@uab.edu
Office: SC 360G2, 1720 7th Avenue South, Birmingham AL 35294-0017
Personal Info:
Dr. Nicholas' clinical subspecialty is movement disorders with a special interest in the treatment of Parkinson's disease. Included in the services provided in his clinic are evaluations for tremors, gait disorders and Parkinson's disease, including surgeries and investigational drug trials. He also provides botulinum toxin injections for cervical dystonia and assists in the care of patients with Parkinson's disease and dementia.

Dr. Nicholas received his B.S. degree in 1982 from the University of Scranton, in Pennsylvania, where he graduated magna cum laude and was enrolled in Alpha Sigma Nu, the National Jesuit Honor Society. He then moved to Texas and received his Ph.D. in Anatomy from the Graduate School of Biomedical Sciences in Galveston in 1987. In 1990, he then earned his M.D. degree from the University of Texas Medical Branch at Galveston and became a member of the National Medical Honor Society, Alpha Omega Alpha. After medical school, Dr. Nicholas spent two years completing a post doctoral fellowship in Neuroscience with Dr. Tomas Hökfelt at the Karolinska Institute in Stockholm, Sweden. In 1992, he returned to the United States and, after concluding his neurology residency and serving as Chief Resident at the University of Alabama at Birmingham, he was appointed Assistant Professor of Neurology with the department in 1996. In 2003, Dr. Nicholas was promoted to Associate Professor of Neurology, and was inducted into the American Neurological Society in 2008.

Dr. Nicholas was board certified by the American Board of Psychiatry and Neurology in 2001, and presently holds joint appointments at UAB as an adjunct faculty in the Department of Neurobiology and the Department of Physiology and Biophysics. He also serves as Assistant Director of Neurology at the Birmingham VA Medical Center, and previously was Co-Director of the Parkinson Disease Information and Referral Center at UAB (in association with the Parkinson Association of Alabama), and Director of the UAB Parkinson Disease Research Laboratory. Dr. Nicholas has been the recipient of numerous teaching awards from the Argus Society for Best Small Group Instructor and Best Lecturer, and serves as co-director of the Medical Neuroscience Module that has also received awards as best medical school course at UAB.

Special Interests
Dr. Nicholas' clinical subspecialty is movement disorders with a special interest in the treatment of Parkinson's disease. His research interests include studying the influence of monoamine neurotransmitters and their receptors on the pathophysiology of Parkinson's disease. This includes the role of alpha-2 noradrenergic receptors in the development of levodopa-induced dyskinesia as a disabling side effect of Parkinson's disease treatment. This is being accomplished in animal models using immunohistochemistry and high-pressure liquid chromatography. Another main objective of his research is to study the role of citrullinated proteins contributing to brain damage in Parkinson's disease, Alzheimer's disease, and multiple sclerosis. It is believed that these altered proteins may result in gliosis and autoimmune mechanisms that further propagate these diseases.

Publications 

Dr. Nicholas in Health System Directory