“This enables us to observe bleeding complications to better understand and study the influence of genes, clinical factors and environment,” Limdi said. That capability is valuable in understanding this process and a key element in securing a $3.5 million grant from the National Heart, Lung and Blood Institute, one of the National Institutes of Health.
UAB’s comprehensive genomic approach will assess both common and rare genetic variations to identify novel genetic variants associated with hemorrhage in warfarin (Coumadin), the most commonly used oral anticoagulant, and also dabigatran (Pradaxa).
|UAB, which developed one of the largest, most racially diverse, prospective warfarin-study cohorts in the country, is uniquely qualified to conduct real-time studies of its effects.|
Limdi, along with colleagues Timothy Beasley, Ph.D., and Nianjun Liu, Ph.D., associate professors in the Department of Biostatistics, and Todd Brown, M.D., assistant professor in the Division of Cardiovascular Disease, are recruiting subjects for the new study. Call 205-996-6009 or email
Published in Research & Scholarship