Clinical Trialsvascular


Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III
(MISTIE III)

Purpose: A phase III, randomized, case-controlled, open-label, 500-subject clinical trial of minimally invasive surgery plus rt-PA in the treatment of intracerebral hemorrhage (ICH).

Principal Investigators: Mario Zuccarello, MD, Issam Awad, MD, Mark R.
Harrigan, MD 
ClinicalTrials.gov Identifier: NCT01827046
Website: braininjuryoutcomes.com


Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)

Purpose: Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.

Principal Investigators: Thomas G. Brott, MD, James F. Meschia, MD, Brajesh K. Lal, MD, George Howard, DrPH, Mark R. Harrigan, MD
ClinicalTrials.gov Identifier: NCT02089217
Website: crest2trial.org.


Study of EG-1962 Compared to Standard of Care Oral Nimodipine in Adults With Aneurysmal Subarachnoid Hemorrhage (Newton 2)

This study is a phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group, efficacy and safety study comparing EG-1962 to standard of care oral nimodipine in adults With aneurysmal subarachnoid hemorrhage.

Purpose: This study compares EG-1962 to enteral nimodipine in the treatment of aneurysmal subarachnoid hemorrhage.

Principal Investigators: R. Loch Macdonald, MD, PhD (Study Chair), Mark R. Harrigan, MD
ClinicalTrials.gov Identifier: NCT02790632
Website: edgetherapeutics.com.


Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease (MyRIAD)

Purpose: The objective of this study is to determine the mechanisms of stroke in patients with Intracranial Atherosclerotic Disease (IAD) by specifically evaluating limitations of antegrade flow through the stenotic artery, distal tissue perfusion to the affected territory, and artery-to-artery embolism. The hypothesis is that non-invasive imaging biomarkers that stratify stroke risk and distinguish mechanisms of IAD.

Principal Investigators: Jose G Romano, MD, Shyam Prabhakaran, MD, David S Liebeskind, MD, Mark R. Harrigan, MD
ClinicalTrials.gov Identifier: NCT02121028


Personnel

Mark R. Harrigan, MD

Winfield S. Fisher, III, MD


Publications

Argo JL, Yellumahanthi DK, Ballem N, Harrigan MR, Fisher WS 3rd, Wesley MM, Taylor TH, Clements RH. Laparoscopic versus open approach for implantation of the peritoneal catheter during ventriculoperitoneal shunt placement. Surg Endosc. 2009 Jul;23(7):1449-55. Epub 2008 Dec 13.PMID: 19083058

Connors JJ 3rd, Sacks D, Furlan AJ, Selman WR, Russell EJ, Steig PE, Hadley MN: Neurovascular Coalition Writing Group. Training, competency and credentialing standards for diagnostic cervicocerebral angiography, carotid stenting, and cerebrovascular intervention: A joint statement from the American Academy of Neurology, the American Association of Neurological Surgeons, the American Society of Interventional and Therapeutic Neuroradiology, the American Society of Neuroradiology, the Congress of Neurological Surgeons, the AANS/CNS Cerebrovascular Section, and the Society of Interventional Radiology. J Vasc Interv Radiol, 2009. Jul:20(7 Suppl):S292-301.

Zhao L, Rubiera M, Harrigan MR, Alexandrov AV. Arterial ReOcclusion and Persistent Distal Occlusion after Thrombus Aspiration. J Neuroimaging. 2010 Jun 21. [Epub ahead of print] PMID: 20572904

Harrigan MR. Hypertension may be the most important component of hyperdynamic therapy in cerebral vasospasm. Crit Care. 2010 May 14;14(3):151. [Epub ahead of print] PMID: 20497601

Rubiera M, Cava L, Tsivgoulis G, Patterson DE, Zhao L, Zhang Y, Anderson AM, Robinson A, Harrigan MR, Underwood E, Horton J, Alexandrov AV. Diagnostic criteria and yield of real-time transcranial Doppler monitoring of intra-arterial reperfusion procedures. Stroke. 2010 Apr;41(4):695-9. Epub 2010 Feb 18.PMID: 20167923

Fusco MR, Harrigan MR. Cerebrovascular Dissections: A Review, Part I. Spontaneous Dissections. Neurosurgery, 2010, submitted and approved, pending publication.

Fusco MR, Harrigan MR. Cerebrovascular Dissections: A Review, Part II. Blunt Cerebrovascular Injury. Neurosurgery, 2010, submitted and approved, pending publication.

D'Agostino SJ, Harrigan MR, Chalela JA, Nicholas JS, Deveikis SI, Jones TM, Deveikis JP. Clinical experience with Matrix2 360 degrees coils in the treatment of 100 intracranial aneurysms. .Surg Neurol. 2009 Jul;72(1):41-7.PMID: 19559926

Ferrell AS, Tubbs RS, Acakpo-Satchivi L, Deveikis JP, Harrigan MR. Legacy and current understanding of the often-misunderstood Foix-Alajouanine syndrome. Historical vignette. J Neurosurg. 2009 Nov;111(5):902-6.PMID: 19344217

Argo JL, Yellumahanthi DK, Ballem N, Harrigan MR, Fisher WS 3rd, Wesley MM, Taylor TH, Clements RH. Laparoscopic versus open approach for implantation of the peritoneal catheter during ventriculoperitoneal shunt placement. Surg Endosc. 2009 Jul;23(7):1449-55. Epub 2008 Dec 13.PMID: 19083058

Harrigan MR, Rajneesh KF, Ardelt AA, Fisher WS. Short term antifibrinolytic therapy prior to early aneurysm treatment in subarachnoid hemorrhage: Effects on rehemorrhage, cerebral ischemia, and hydrocephalus. Submitted, Neurosurgery, 2009

Menendez JY and Harrigan MR. X-Configuration stent-assisted coiling: Case illustration. Submitted, Neuroradiology, 2009

Zhao L, Rubiera M, Harrigan MR, Alexandrov AV. Arterial re-occlusion and persistent distal occlusion in a stroke patient after thrombus aspiration. In preparation, 2010

Van Gompel JJ, Griessenauer CJ, Scheithauer B, Amrami KK, Spinner RJ. Vascular malformations as a rare cause of sciatica – a case series. Neurosurgery 2010, accepted for publication.

Fleming JB, Shannon CN, Hoh, B; Fargen KM, Mericle RA; Simon SD; Pride GL; Purdy PD; Welch BG; Harrigan MR. Rebleeding Risk after Treatment of Ruptured Intracranial Aneurysms. Submitted, awaiting publication

Naftel RN, Tubbs RS, Reed GT, Wellons JC. Small Ventricular Access Prior to Rigid Neuroendoscopy: Technical note. Journal of Neurosurgery-Pediatrics. (In Publication)

Fusco MR, Harrigan MR. Cerebrovascular Dissections: A Review, Part I. Spontaneous Dissections. Neurosurgery, 2010, submitted and approved, pending publication.

Fusco MR, Harrigan MR. Cerebrovascular Dissections: A Review, Part II. Blunt Cerebrovascular Injury. Neurosurgery, 2010, submitted and approved, pending publication.