Comprehensive Datasets

Core A has developed and maintained several large comprehensive datasets of patients with and without AKI. These datasets enable researchers to access information on epidemiology, process of care, factors contributing to variations in patient care and their associations with outcomes of patients from high risk for AKI to AKI dialyzed patients. Core A has the necessary protocols to help investigators with appropriate, institutional human subjects approval, and to have access to data derived from de-identified patients. Given the increasing interest and capabilities for big data analysis, Core A has developed protocols for investigators to gain access to large datasets. These datasets provide rich resource for investigators for data minig of longitudinal data on the natural history and changing trends in the management of AKI across the worls. Examples of investigators who have utilized or planned to use these resources are outlined below.

 Comprehensive Databases Accessible for AKI Research  
 Database Data Souce Data Content
International ICU AKI Registry 33 centers worldwide The Registry includes detailed information on co-morbidities, risk factors for AKI, clinical and laboratory data, fluid balance status, severity of illness scores, dialysis requirements and outcomes through hospital discharge. Currently, 3,534 of 13,105 patients who were screened had AKI and 2,256 are enrolled.
Drug-induced Renal Injury Consortium (DIRECT) 42 centers worldwide The DIRECT study has enrolled 634 patients (adult, n=493, pediatric, n=141) with drug-induced kidney disease.  Blood, urine and DNA samples have been collected as well as clinical course of the injury and outcomes up to 90 days post event.
Global Snapshot of AKI International Society of Nephrology (ISN) 0by25 project The dataset includes phenotypic information on 4018 patients (3664 adult and 354 pediatric) enrolled from 289 centers in 92 countries from Sep-Dec 2014. This dataset provides detailed information on presenting symptoms, risk factors, course and outcome over 7 days of patients with AKI.
 Big Databases Accessible for AKI Research  
UAB and UCSD Clinical data warehouse from EHR UCSD EPIC with Clarity
UAB Cerner Datasets
Clinical lab, medication and administrative data for outpatient and inpatient encounters at UAB and UCSD.

The UCSD/O'Connor TSP Resource in Hypertension

This resource includes data generated from many of Dr. O'Connor's diverse and complementary studies.
  • dbGap
  • Biological Samples
  • Metabolomics
See full details here