Core A has developed and maintained several large comprehensive datasets of patients with and without AKI. These datasets enable researchers to access information on epidemiology, process of care, factors contributing to variations in patient care and their associations with outcomes of patients from high risk for AKI to AKI dialyzed patients. Core A has the necessary protocols to help investigators with appropriate, institutional human subjects approval, and to have access to data derived from de-identified patients. Given the increasing interest and capabilities for big data analysis, Core A has developed protocols for investigators to gain access to large datasets. These datasets provide rich resource for investigators for data minig of longitudinal data on the natural history and changing trends in the management of AKI across the worls. Examples of investigators who have utilized or planned to use these resources are outlined below.