2Uterine mass in a 45 year old woman.

 What is the most likely diagnosis?

A. Papillary squamous cell carcinoma
B. High grade squamous intraepithelial lesion (CIN3).
C. Invasive, well differentiated squamous cell carcinoma.
D. Condyloma with atypia.







The answer is “A. Papillary squamous cell carcinoma”


Papillary squamous cell carcinoma is a rare variant of squamous cell carcinoma of the cervix that histologically resemblance papillary urothelial carcinoma of the bladder. On a superficial biopsy this lesion can be mistaken for a squamous cell carcinoma in situ, verrucous carcinoma or as condyloma accuminatum with atypia. Papillary squamous cell carcinoma can be aggressive and metastasize.


  1. R. J. Kurman, L. Hedrick Ellenson, B. M. Ronnett (eds.), Blaustein’s Pathology of the Female Genital Tract (6th ed.), DOI 10.1007/978-1-4419-0489-8_6, Springer Science+Business Media LLC 2011

 Contributed by
Jennifer Gordetsky, M.D.