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Clinical History

A 28 year old male presents with gross hematuria after a trip abroad. Cystoscopy and biopsy are performed.

Choose the Correct Diagnosis: 

  1. Schistosomiasis with reactive urothelium
  2. Schistosomiasis with Carcinoma in situ
  3. Schistosomiasis with Eosinophilic cystitis
  4. Schistosomiasis with invasive urothelial carcinoma

Answer: 1. 

Discussion:

Schistosomiasis eggs are present. The urothelium shows uniform nuclear enlargement, maintained polarity and prominent nucleoli, consistent with reactive urothelium. Numerous eosinophils are a common finding in cases of schistosomiasis but can also be a non-specific finding in many conditions that cause chronic irritation of the bladder.

Contributed by Jennifer Gordetsky, M.D., Associate Professor, UAB Department of Pathology