Case History

A 67-year-old man with a history of hypertension, diabetes and chronic pancreatitis presented with diarrhea and acute renal failure with serum creatinine of 5.6mg/dL (baseline 1.1mg/dL).  A renal biopsy performed showed moderate acute tubular injury (PASH Fig:1) with multiple foci of calcium oxalate crystals (H&E Fig: 2 and H&E polarized: 3). IF and EM were negative.

What is the most common cause of oxalosis?

  1.       Ethylene glycol poisoning.
  2.       Excessive ingestion of oxalate rich diet.
  3.       Enteric hyperoxaluria.
  4.       Pyridoxine deficiency.

Pic 1 Pic 2   Pic 3

Case contributed by: Huma Fatima, M.D., Assistant Professor, Anatomic Pathology