Case History

Gastric biopsy in an 80-year-old female. 

What is the best diagnosis?

  1.        H. pylori gastritis
  2.        Autoimmune gastritis
  3.        Iron-pill gastritis
  4. Doxycycline-associated gastritis

Case of the week gastric biopsy 1 Case of the week gastric biopsy 2

 Answer: This biopsy shows eosinophilic necrosis of the superficial capillaries and capillary microthrombi. These histologic features are characteristically described with doxycycline-related gastric mucosal injury. H. pylori immunostain was negative.

Case contributed by: Deepti Dhall, M.D., Professor & Associate Director, Anatomic Pathology, GI Section Head