Research and Clinical Laboratories

The UAB Department of Pathology has several research and clinical labs under its purview: 

Faculty Research

C. Ryan Miller, M.D., Ph.D., Division Director, Neuropathology

ihc astrocytes e1565626411477The mission of Dr. Miller's Lab is to develop genomics-driven approaches to diagnosis and treatment of gliomas, the most common primary brain tumors. The focus of the lab is to define the molecular changes that drive the evolution of gliomas during their progression from low-grade precursors to malignant, high-grade neoplasms. The particular focus is the most aggressive glioma, glioblastoma, and seeking to identify the cell type(s) from which these lethal tumors arise, to define the role of tumor cell plasticity and glioma stem cells (GSC) in glioma biology, and to define the wiring diagrams that control proliferation and migration/invasion of glioma cells that arise from different cell types in the normal mammalian brain.  

Mythreye Karthikeyan, Ph.D., Associate Professor, Molecular & Cellular Pathology

Screen Shot 2020 06 02 at 12.51.47 PMThe mission of Dr. Karthikeyan's lab is to develop an in-depth understanding of mechanisms and consequences of of altered signaling in disease to discover innovative avenues for therapeutics. The lab is currently focused on understanding cellular and molecular mechanisms of tumor progression and metastasis in gynecological cancers. Emphasis is on contextual consequences of altered signaling by the broad TGFb/BMP/Inhibin-Activin family. Our approach is cross-disciplinary interfacing with biochemistry, molecular cell biology and systems approaches including the development of models tailored to address specific aspects of metastasis.

UALCAN

Screen Shot 2020 06 02 at 12.55.02 PMSooryanarayana Varambally, Ph.D., is an Associate Professor in Molecular and Cellular Pathology, and founder of UALCAN. While not a lab, UALCAN is a comprehensive, user-friendly, and interactive web resource for analyzing cancer OMICS data. It is built on PERL-CGI with high quality graphics using javascript and CSS. UALCAN is designed to, a.) provide easy access to publicly available cancer OMICS data (TCGA and MET500), b.) allow users to identify biomarkers or to perform in silicio validation of potential genes of interest, c.) provide graphs and plots depicting gene expression and patient survival information based on gene expression, d.) evaluate gene expression in molecular subtypes of breast and prostate cancer, e.) evaluate epigenetic regulation of gene expression by promoter methylation and correlate with gene expression, f.) perform pan-cancer gene analysis, and, g.) provide additional information about the selected genes/targets by linking to HPRD, GeneCards, Pubmed, TargetScan, The human protein atlas, DRUGBANK, Open Targets, and the GTEx. These resources allow researchers to gather valuable information and data about the genes/targets of interest. 

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Clinical Research

Pathology Core Lab 

Figure 1.2 Plastic embedded bone section with Goldners trichrome at higher MagnificationThe Pathology Core Research Lab provides state-of-the-art histology and histomorphometric analysis of various tissue types, and specializes in bone samples. The present location in the basement of Lyons Harrison Research Building has approximately 2,500 square feet of space in close proximity to many researchers who utilize its services. Managed by Dezhi "Annie" Wang, M.D., HTL, and the Core's Co-Directors, Shi Wei, M.D., Ph.D., Professor and Associate Director, Anatomic Pathology, and Gene P. Siegal, M.D., Ph.D., Robert M. Mowry Endowed Professor, Executive Vice Chair, Anatomic Pathology. 

Tissue Biorepository

Screen Shot 2020 06 02 at 1.01.06 PMThe mission of the UAB Tissue Biorepository (UAB-TBR) is to collect, process, store, and distribute high-quality human tissue specimens to investigators of UAB, members of the O’Neal Comprehensive Cancer Center and others to conduct investigations that advance molecular medicine to individualize treatment and improve clinical care.


Diagnostic Mycoplasma Laboratory

Screen Shot 2020 06 02 at 1.03.24 PMThe UAB Diagnostic Mycoplasma Laboratory was established in 1984 to provide laboratory services to patients at the UAB Medical Center and to support clinical research studies that required detection of mycoplasmas in human diseases. Recognizing the need for specialized diagnostic services for detection of mycoplasmas in clinical specimens, the laboratory was eventually expanded to provide service as a referral laboratory for hospitals throughout the United States. Our experience in detection and identification of human mycoplasmas using culture and nucleic acid amplification technology, and performance of in vitro susceptibility testing makes us unique as a microbiology reference laboratory. Our laboratory is licensed by the State of Alabama, certified by the College of American Pathologists (CAP), and the Clinical Laboratory Improvement Act (CLIA). Sixto Leal, M.D., Ph.D., is an Assistant Professor in Laboratory Medicine, and director of the Diagnostic Mycoplasma Laboratory.