Several faculty members from the Division of Molecular and Cellular Pathology recently published articles based on their respective areas of research. Read more about their research and publications: 

Joanne Murphy-Ullrich, Ph.D., Professor

Dr. Murphy-Ullrich published the following article on April 3: 
"Calreticulin is important for the development of renal fibrosis and dyfunction in diabetic nephropathy" in Matrix Biology Plus.

010UAB_Pathology2018.jpgJoanne Murphy-Ullrich, Ph.D.

Adam Wende, Ph.D., Associate Professor

Dr. Wende published two articles back to back on the following topics:
"Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling," in the Journal of Clinical Investigation Insight. https://insight.jci.org/articles/view/134920

"Differential DNA methylation encodes proliferation and senescence programs in human adipose-derived mesenchymal stem cells," in Frontiers in Genetics. https://www.frontiersin.org/articles/10.3389/fgene.2020.00346/abstract

Adam_5.jpgAdam R. Wende, Ph.D.

Sooryanarayana Varambally, Ph.D., Associate Professor, co-authored with Upender Manne, Ph.D., Professor the following two articles:

"Therapeutically Actionable PAK4 Is Amplified, Overexpressed, and Involved in Bladder Cancer Progression," in Oncogene: https://pubmed.ncbi.nlm.nih.gov/32231273/

"PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer," in the journal, Cancers: https://www.mdpi.com/2072-6694/12/4/772

And a third, "PRDM16 Suppresses HIF-targeted Gene Expression in Kidney Cancer," in the Journal of Experimental Medicine: https://www.ncbi.nlm.nih.gov/pubmed/3225151.

Varambally1.jpgSooryanarayana Varambally, Ph.D..             003UAB_Pathology2018.jpgUpender Manne, M.S., Ph.D.

Rajaskeran Namakkal Soorappan, Ph.D., Associate Professor, published the following two papers on reductive stress, in two journals:

"Reductive Stress Impairs Myogenic Differentiation," in Redox Biology: https://www.sciencedirect.com/science/article/pii/S221323172030183X?via%3Dihub

"Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction," published February 2020 in Antioxid Redox Symbol, with Victor Darley-Usmar, Ph.D., Professor, MCP. https://www.ncbi.nlm.nih.gov/pubmed/32064894

Of the research leading to the publications, Dr. Namakkal-Soorappan said the following: "These important discoveries explain the impact of chronic reductive-redox conditions in cardiac pathology and skeletal muscle regeneration. In particular, the ARS paper highlights the impact of reductive stress on inducing a unique pathological cardiac remodeling called “heart failure with increased ejection fraction (HFiEF)” as opposed to well-known HFpEF (preserved ejection fraction) pathology. This is the FIRST model to report HFiEF. therefore, we believe that future/ongoing studies in humans might explain whether too much of antioxidants can lead to HFiEF in cardiac patients.

Screen Shot 2020 04 02 at 4.28.22 PMRajasekaran Namakkal-Soorappan, Ph.D..    RS13593 Darley Usmar 4 scrVictor Darley-Usmar, Ph.D.