July 19, 2012
Media Contact: Sharon Likos
BIRMINGHAM, Ala. - Frederick Goldman, M.D. has been awarded a research grant from the Diamond Blackfan Anemia Foundation in support of his research to find a cure for Diamond Blackfan anemia (DBA), a rare, childhood bone marrow failure syndrome characterized by the inability to make red blood cells. The grant provides $116,000 over two years and to help Dr. Goldman continue his cutting edge research on DBA.
The title of Dr. Goldman's research proposal is "Toward a cure for DBA: Creation of patient-specific, gene-corrected hematopoietic stem cells using induced pluripotent stem cell technology." This is a collaborative project with Dr. Tim Townes of the UAB Department of Biochemistry. Dr Goldman plans to correct the genetic defect in skin cells obtained from patients with DBA, then convert the skin cells into hematopoietic stem cells that are once again capable of making red blood cells. The ultimate goal of these preclinical studies is to make this a therapeutic option, and possible cure, for patients who currently are being treated with monthly blood transfusions.
Dr. Goldman is Professor and Director of the Lowder Blood and Marrow Transplant Program at the Alabama Center for Childhood Cancer and Blood Disorders. He joined the faculty of the UAB Division of Pediatric Hematology-Oncology in 2009. The Lowder Blood and Marrow Transplant Program is the only dedicated Pediatric Blood and Marrow transplant center in Alabama.
The Alabama Center for Childhood Cancer and Blood Disorders is a partnership between Children's of Alabama and the UAB Division of Pediatric Hematology-Oncology. More than a dozen highly-specialized pediatric hematologists, oncologists and blood and marrow transplant physicians at Children's provide care to infants through young adults up to age 25. A multidisciplinary team approach provides family-centered treatment and support through a variety of innovative services from the day of diagnosis through treatment, cure and long-term follow-up.