The Division of Pediatric Endocrinology and Diabetes offers an energetic research environment.  Faculty and fellow research projects include the entire spectrum of pediatric endocrinology conditions, both basic science and clinically-oriented projects. 

Research coordinator:
Tammi Skelton RN
Section of Pediatric Endocrinology and Diabetes
Phone: 205-996-9569

Clinical/research programs:

  • The Comprehensive Diabetes Center (TCDC):A Comprehensive Diabetes Center was established in 2007. The Centers research interests include T- and B-cell immunology, pancreatic β cell biology and developmental biology. Centers research is directed at understanding the fundamental issues related to the development of type 1 diabetes. The goal the TCDC is to identify novel mechanisms or strategies to prevent or cure this disease.
  • Endocrine Newborn Screening Center:
    The endocrine division collaborates with the Alabama State Screening program to optimize immediate and long-range follow up care of newborns with congenital hypothyroidism and adrenal hyperplasia. Longitudinal data analysis of clinical outcomes is a key component.

Particular areas of research include:

  • Pathogenesis of Type 1 and Type 2 diabetes
  • Optimizing current and long term health and well being in patients with diabetes
  • The regulation of cortisol production by fat and liver tissue and its impact in obesity and diabetes. These investigations probe the crucial cortisol production enzyme 11 Beta hydroxysteroid dehydrogenase.
  • Fast track continuous subcutaneous insulin infusion (CSII) in young children with newly diagnosed type 1 diabetes mellitus (T1DM)
  • Implantable Antenna Sensors for Continuous Glucose Monitoring
  • Autonomy Support Psychoeducation for Parents and Middle Adolescent with Type 1 Diabetes
  • Diagnosing the Heterozygous State of Congenital Adrenal Hyperplasia Using Gas Chromatography/Mass Spectrometry Analysis of Random Urine Samples
  • Effect of incretin therapies on weight and glycemic control in children and adolescents with Type 2 Diabetes Mellitus
  • Effect of vitamin D on insulin secretion and sensitivity
  • The regulation of FGF23 by growth hormone and the latter's effect on phosphate homeostasis
  • The regulation of FGF 23 in endocrinological disorders
  • Evaluation of etiology of difficult hypertriglyceridemia
  • Lipid disorders in diabetes and obesity
  • Relationship between idiopathic bone age advancement with adrenal androgen production
  • The role of aromatase inhibitors in males with idiopathic bone age advancement
  • Current clinical therapies in cystic fibrosis related diabetes
  • Insulin sensitivity and the GH/IGF-1 axis in young children with cystic fibrosis
  • Trial Net:
    o We are an active participant in Trial Net (a study screening relatives of children with type 1 diabetes to determine if any family member is at risk for developing diabetes).
  • Growth Hormone registries:
    o The Endocrinology Division participates in post marketing surveillance and the national registries of multiple growth hormone products.
  • Exenatide in Adolescents:
    o Clinical trial examining the safety and efficacy of Exenatide in Adolescents with Type 2 Diabetes

Currently the Section has several active research projects approved by the University of Alabama Institutional Review Board. The Division avidly pursues publication of original scientific work well-respected peer-reviewed journals.