University of Alabama at Birmingham (UAB)
     School of Medicine
          Department of Pediatrics
               Department of Pediatrics, Divisions (in alphabetical order)

Children's of Alabama (COA)
     Child Health Research Unit (CHRU)
     COA Pharmacy
     Laboratory Space
          Department of Pediatrics Molecular Diagnostic Laboratory
          Department of Pediatrics Molecular Resistance Laboratory

UAB Hospital
     The Women and Infants Center

     The Institute of Cancer Outcomes and Survivorship
     University-Wide Interdisciplinary Research Centers (UWIRCs)
     UAB Center for Clinical and Translational Science (CCTS)
     UAB Comprehensive Cancer Center (CCC)

If there are other descriptions you would like to see posted or if you have additions/revisions for any of the write-ups, please email Cheryl Perry.

The University of Alabama at Birmingham (UAB)

The University of Alabama at Birmingham (UAB) is a comprehensive urban university with over 19,000 students from across the US and internationally. As a state-affiliated institution, UAB ranks among the top 15 public universities in federal research support, with grants and contracts awarded exceeding $452 million (FY2016). As one of three autonomous institutions within The University of Alabama System, UAB is the only four-year, public university in the state’s largest metropolitan area. It spans more than 86 blocks in the city center with over 250 buildings providing over 11 million feet of assignable space. UAB’s economic impact on Alabama already exceeds $5 billion (FY2013) and by 2020, it is projected to grow to $6.6 billion, generate 72,449 jobs and create $431.4 million in state and local tax revenue. As of the fall of 2016, the UAB workforce employed 21,245 people, had a faculty of 2,543 (42 percent of whom are female), and had a student enrollment of 19,535 at the undergraduate through doctoral levels. UAB is comprised of 10 academic colleges and schools in the health sciences and academic areas. The UAB Academic Health Center includes the Schools of Medicine, Dentistry, Nursing, Optometry, Public Health, Health Professions, the Graduate School, and the Lister Hill Library of the Health Sciences. The University’s academic campus consists of the College of Arts and Sciences, the Collat School of Business, the Schools of Education and Engineering, the Graduate School, and the Mervyn Sterne Library.

School of Medicine

As the largest School within UAB, one of the South's premier research universities, the School of Medicine is dedicated to the education of physicians and scientists in all of the disciplines of medicine and biomedical investigation. Led by Selwyn M. Vickers, MD, Dean and Senior Vice President, the school provides medical education and internship opportunities for students throughout the world. Its comprehensive approach to teaching future physicians covers all facets of medicine, including medical education, research, and patient care -- delivered in one of the most technologically advanced medical facilities in the country. The School of Medicine has nationally recognized clinical programs in many areas including, but not limited to, Oncology, Neurology, Psychiatry, and Immunology/Rheumatology. UAB is also a national leader in organ transplantation. Many of UAB’s most productive extramurally-funded research centers, including the Comprehensive Cancer Center, Comprehensive Diabetes Center, Center for AIDS Research, Minority Health and Health Disparities Research Center, and others are based in the School and report to the Dean. The School is also a national leader in research, and has been ranked in the top 30 of NIH funded Schools of Medicine for more than 20 years.  In FY2016, it had more than $241 million in active grants and contracts, with over $186 million from the NIH.  Currently, the UAB School of Medicine includes nearly 800 students and more than 900 residents and 1,400 full-time faculty in 26 academic departments.

Department of Pediatrics 

The UAB Department of Pediatrics at Children's of Alabama is comprised of 19 Subspecialty Divisions each with an educational, research and clinical focus.The faculty of the UAB Department of Pediatrics at Children's of Alabama provides a diverse and extensive spectrum of medical expertise and health care services, from primary care to subspecialty services. Over the past five years the department has experienced significant growth in the number of full-time medical pediatric faculty. Currently there are over 241 faculty in general pediatrics and subspecialty divisions.

The faculty of the Department of Pediatrics records more than 272,000 outpatient visits, including approximately 73,100 patients seen through the pediatric emergency medicine division. More than 15,500 subspecialty patients and general pediatric inpatient admissions were managed by the pediatric faculty. In addition, the Neonatology division provides coverage for the UAB Medical Center as well as four private, not-for-profit community hospitals. Total inpatient days are in excess of 92,200.

The Department of Pediatrics has a major commitment to research and consistently ranks in the top 20 among all departments of pediatrics in the country in NIH funding. Through research, we are contributing to a better understanding of the causes of many life-threatening diseases as well as advancing many new forms of treatment.

Department of Pediatrics, Divisions (in alphabetical order) 

Division of Allergy and Immunology
Board-certified pediatric allergist/immunologists in the division specialize in the treatment of patients with IgE mediated diseases including asthma, allergic rhinitis, atopic dermatitis, food allergy, urticaria, angioedema, and stinging insect and drug allergy.  In collaboration with physicians from the Division of Gastroenterology and Nutrition, allergists in the division assist in the evaluation of patients with eosinophilic gastrointestinal diseases such as Eosinophilic Esophagitis (EoE).  Division clinical immunologists diagnose and treat children with primary immune deficiencies including Severe Combined Immune Deficiency (SCID), primary antibody deficiencies, phagocyte deficiencies and complement deficiencies.  Research interest include studies of T and B cell differentiation, mechanisms underlying immune deficiency syndromes, and immunologic abnormalities leading to autoimmunity.  Division faculty are engaged in research in the pathophysiology of asthma and allergic disease as well as primary immune deficiency and autoimmunity.

Division of Critical Care
The division provides services to patients with life-threatening diseases in the new 22 bed Pediatric Intensive Care Unit at Children’s of Alabama.  Located within the Department of Pediatrics, the Division includes 9 faculty members, and 6 sub-specialty trainees.  It is a mixed medical-surgical, pediatric and adolescent unit with emphasis on cardiopulmonary, neurological and surgical problems including; respiratory failure, pneumonia, croup, asthma, near drowning, acute renal failure, child abuse, complex and refractory seizure disorders, meningitis, Guillain-Barre Syndrome, ingestions, diabetes, neurosurgery, trauma, facial reconstructions and scoliosis.

Division of Emergency Medicine
As Alabama’s main tertiary care center for the care of children and as the state’s only designated Level 1 pediatric trauma center, the division has the privilege and responsibility of caring for the most critically ill children in Alabama.  To best care for them, our pediatric emergency medicine physicians are surrounded by an excellent team of nurse practitioners, registered nurses, and ancillary staff members.  Physicians also have 24 hour access to pediatric medical and surgical subspecialists as well as 24/7 in-house PICU and CVICU coverage. 

The Benjamin Russell Children’s Hospital opened in August of 2012, expanding the Children’s of Alabama campus with a stunning 12 story facility dedicated to inpatient, emergency, and surgical services.  The new Emergency Department has 53 rooms including 4 major resuscitation rooms and a 4 bed unit specialized for the care of psychiatric patients.  The radiology department, including MRI and CT, is connected to the ED offering rapid access to multiple imaging modalities.

Division of Endocrinology
The Division of Pediatric Endocrinology covers a wide range of hormone-related disorders in children using a team approach.  About half of its patients are referred for Type 1 and Type 2 diabetes.  Other areas diagnosed, followed, and treated by UAB pediatric endocrinologists include, but are not limited to, adrenal gland disorders, bone and calcium disorders, growth disorders, pituitary gland disorders, hypoglycemia, puberty disorders, thyroid disease, and genetic disorders.

Division services include a broad range of clinical, research, and training programs.  Faculty and fellow research projects include the entire spectrum of pediatric endocrinology conditions, both basic science and clinically-oriented projects, totally over $600,000.  Training includes the Joseph S. Bruno Pediatric Endocrinology training program, a 3-year comprehensive experience that incorporates clinical care, research activities, and evidence-based learning.  The program is ACGME accredited and accepts one fellow per year.

Division of Gastroenterology, Hepatology, and Nutrition
The division provides comprehensive multidisciplinary evaluation and management of all pediatric gastrointestinal, liver and nutritional problems with a focus on multidisciplinary patient-centered care (including close interaction with the departments of Pediatric Surgery, Radiology, Pathology, Anesthesiology and Nutrition).  State of the art GI laboratory and endoscopy facilities perform a number of diagnostic and therapeutic procedures which include: upper and lower endoscopy with biopsies, polypectomies, variceal sclerotherapy and banding, foreign body removal from upper GI tract, dilations, percutaneous liver biopsies, PH probe, hydrogen breath testing and anorectal motility testing.  Special interests of division members include GER, abdominal pain, motility disorders, liver disease, lipid disorders, functional GI disorders, childhood obesity, and inflammatory bowel disease.  The division also provides both inpatient and outpatient consultative services. 

Division of General Pediatrics and Adolescent Medicine
The division is home to more than 75 specially trained physicians and staff.  All physicians are board certified in Pediatrics and many are additionally certified in the sub-specialty areas of Adolescent Medicine and Developmental-Behavioral pediatrics.  Division personnel excel in teaching, research, and clinical care responsibilities.  Faculty supervise care provided by residents and students in a variety of clinics ranging from primary care to specialty services through UAB and Children's of Alabama.  Additionally, several faculty see patients at the UAB Sparks Center for evaluation of developmental and behavioral issues.  Research funding in the division currently totals over $1.6 million.

Division of Hematology-Oncology
The division is a component of the UAB Department of Pediatrics and the UAB Comprehensive Cancer Center and is located within Children’s of Alabama.  Its programs are housed in the Alabama Center for Childhood Cancer and Blood Disorders, which treats 90 percent of all pediatric cancer and other blood disorders patients diagnosed in Alabama and offers specific treatment and research programs for pediatric oncology, hematology, neuro-oncology, blood and marrow transplantation, developmental therapeutics and psychosocial care.  Division goals include state-of-the-art personalized clinical care, education and training, and the clinical translation of basic research focused on childhood cancer and blood disorders.  The division currently has over $3 million in research funding. 

Division of Infectious Diseases
The division provides outpatient and inpatient care for infants, children, and adolescents with illness of known or suspected infectious etiology.  Clinical care activities may include both infectious diseases that are difficult to diagnose and those requiring hospitalization such as bloodstream infections, meningitis, serious pneumonias, and viral diseases.  The division is internationally known for its studies of congenital and perinatal viral infections.  For 50 years, it has defined the natural history, pathogenesis, diagnosis, treatment, and prevention of congenital cytomegalovirus (CMV) infections and neonatal herpes simplex virus (HSV) disease.  It also houses the Collaborative Antiviral Study Group (CASG), which has defined the treatment of neonatal HSV and congenital CMV, including longer-term suppressive therapy with oral acyclovir following neonatal HSV disease and most recently longer-term oral valganciclovir therapy in infants with symptomatic congenital CMV disease.  Promising new antiviral drugs are being evaluated in animal models and Next Generation Sequencing is being used to identify viral subpopulations with diminished susceptibility to antiviral drugs commonly used to treat life-threatening diseases.  The division currently includes 8 physician scientists and 6 PhDs.  Collectively, these investigators are responsible for over $16 million in research funding.

Division of Neonatology
The Division currently has fifteen faculty members.  Research interests are in the following areas: respiratory distress syndrome, neonatal infections and immunology, persistent pulmonary hypertension, lung development, lung assist devices, lung injury, ventilation techniques in newborns, gastrointestinal development, necrotizing enterocolitis, neonatal apnea, cardiovascular problems, and complications arising from prematurity.  Division faculty members are active in many research endeavors, including the 17-center Neonatal Research Network and the Global Network for Women's and Children's Health Research, which are funded by the NIH.  Currently the division holds over $2.3 million in research funding.  The Regional Newborn Intensive Care Unit (RNICU) at University Hospital is the oldest and largest newborn ICU in the state.  Because of strong clinical research ties, many cutting edge therapies are available in the RNICU before they are introduced elsewhere.  The RNICU at UAB is a 120 bed Level III nursery and the primary referral nursery for maternal-fetal patients, critically ill neonates, and sick infants with congenital heart disease.  The division accepts referrals of neonates with any illness including genetic, cardiac, and surgical problems from the state, the nation, and from overseas.  The Newborn ICU at Children’s of Alabama is available for babies with surgical problems or complex, multi system congenital disorders.  

Division of Nephrology
The nephrology team, which includes specialized nurses, a nutritionist, social workers, family counselors and faculty, evaluate and treat children with kidney disease from infancy to adolescence.  They care for those with urinary tract infections, hypertension, hematuria, proteinuria, glomerulonephritis, and nephrotic syndrome, vasculitis, and systemic lupus erythematosis and chronic kidney disease, including those who require chronic dialysis or transplantation. 

The renal care center is one of the largest comprehensive pediatric dialysis units in the United States offering acute and chronic dialysis therapies.  The specialized staff offers peritoneal dialysis, hemodialysis, continuous renal replacement therapies, kidney biopsies, and plasmapheresis for infants, children and adolescents. In order to maximize health and quality of life, the renal care center is one of three pediatric programs who train qualifying pediatric patients to perform hemodialysis at home using NXSTAGE Portable Dialysis Machine.

In conjunction with the Division of Transplantation Surgery at UAB, the Division of Nephrology is one of the largest pediatric kidney transplant programs in the country.  Multi-center studies determine the optimal immunosuppression therapy to maximize long-term outcomes for children with kidney transplantation.

The research and clinical interest of the division are broad.  Its personnel participate in multi-center studies on drug discovery/pharmacokinetics, assessment, progression and treatment of chronic kidney disease in children.  The division has a long history of successful participation in NIH, investigator initiated, and industry sponsored clinical trials.  Over the past 5 years, it has participated in 10 industry-sponsored, 8 investigator initiated and 10 NIH-sponsored trials, and enrolled over 520 patients.  Current research totals over $700,000.  More importantly, there are systems in place to maximize recruitment and retention in all studies.  All personnel are certified in Human Subjects Protection and maintain International Air Transportation Association (IATA) certification.  The division also has an exemplary track record in maintaining compliance with study requirements throughout trials.

Laboratory Space -- The laboratory space dedicated to the Division of Pediatric Nephrology is located in the Dearth Tower of the Benjamin Russell Children's Hospital Campus.   There is ample room for processing of samples, performing diagnostic and research measurements.  There are several -20° and -80° freezers and refrigerators dedicated to the Division of Pediatric Nephrology.  All samples are bar-code labeled and tracked through the Freezerworks software. 

Office Space -- The office space for the Division of Pediatric Nephrology is located on the 5th floor of the Lowder Building of the Benjamin Russell Children’s Hospital Campus.  All research team members  and  researchers  have  a  dedicated  Dell  Personal  Computer  with  the  software and hardware needed to perform necessary duties.

Division of Neurology
The division provides inpatient consultative services at both Children's of Alabama and UAB Hospital.  In addition, the service administers and directs a four bed inpatient Epilepsy Monitoring Unit, with plans for expansion in the future.  Patient diagnoses covers a range of problems including seizure disorders, neurodegenerative diseases, primary muscle diseases, developmental problems and acute encephalopathies.  The division also provides ambulatory services through general pediatric neurology clinics at Children's and sleep clinics.  An expanding research program is investigating basic and clinical problems related to epilepsy, child development, genetics and biochemical diseases.  The division currently has over $2.3 million in grant funding.

Division of Pulmonary and Sleep Medicine
The division is a leader in all facets of academic medicine including care, education, and research.  It includes 12 faculty members and nearly 85 divisional personnel dedicated to advancing our understanding and treatment of pediatric pulmonary disorders.  It is the home of the MCHB-funded Pediatric Pulmonary Center (PPC), the UAB CFFT Therapeutic Development Network Translational Research Center, the UAB Center for CFTR Detection Core within the CFFT-TDN, a CFF accredited CF Care Center, the Child Health Research Unit (CHRU) of UAB's Center for Clinical and Translational Science (CCTS), and the Translational Research in Normal and Disordered Development (TReNDD) Program.  It supports subspecialty fellowship training in both Pediatric Pulmonology and Sleep Medicine, and master's level training in nursing, social work, nutrition, and respiratory therapy.  Divisional grant support currently totals over $600,000.

Division of Rehabilitation Medicine
The division is made up of doctors, nurses, therapists and others who specialize in the prevention, diagnosis, treatment and management of injuries and conditions that affect the brain, spinal cord, nerves, bones and muscles of children and adolescents.  Commonly treated conditions include traumatic brain injury, spinal cord injury, cerebral palsy, spina bifida, muscular dystrophy and brachial plexus injury.  The division utilizes an interdisciplinary approach to address the prevention, diagnosis, treatment and management of congenital and childhood onset physical impairments including related or secondary medical, physical, functional, psychosocial, cognitive and vocational limitations or conditions, with an understanding of the life course of disability.  Its program collaborates with other agencies and organizations to serve children with disabilities and encourages child/family involvement in support groups and educational programs when appropriate.  The division also serves as an advocate for disabled children so that each will be able to achieve the highest level of independent functioning possible. 

Division of Rheumatology
Pediatric Rheumatology diagnoses and treats children with autoimmune disorders, including juvenile arthritis, lupus, myositis, scleroderma, and various vasculitides.  A variety of treatment options are available from intraarticular corticosteroid joint injections to newer biologic agents that target inflammatory cytokines.  There are currently 5 clinical faculty members and 3 Pediatric Rheumatology nurse practitioners with ongoing recruiting efforts to expand the physician-scientist base of the division.  Division research covers basic mechanisms of T lymphocyte function, clinical studies of temporomandibular joint arthritis and macrophage activation syndrome, and several projects aimed at optimizing the treatment of juvenile idiopathic arthritis (JIA).

Children's of Alabama (COA)

Children’s of Alabama, part of the Children’s Health System, provides pediatric care while serving as the primary site for education in pediatrics at UAB. The private, not-for-profit hospital is ranked among the best pediatric medical centers in the nation by US News & World Report. Children’s provided care for youngsters from every county in Alabama, 46 other states and seven foreign countries last year, representing more than 676,000 outpatient visits and more than 15,000 inpatient admissions. With more than 2 million square feet, it is the third largest pediatric medical facility in the U.S. Children’s offers inpatient and outpatient services across its Russell Campus on Birmingham’s historic Southside with additional specialty services provided at Children’s South, Children’s on 3rd and in Huntsville and Montgomery. Primary care is provided at more than a dozen medical offices in communities across central Alabama. Children’s of Alabama is the only medical center in Alabama dedicated solely to the care and treatment of children.

In 2012, Children’s opened two new facilities, strengthening its ability to serve pediatric patients statewide. The Benjamin Russell Hospital for Children, a 12-story, 760,000-square-foot, $400 million expansion allowed Children’s to increase its licensed beds from 275 to 350, ranking Children’s in the top 15 pediatric medical centers based on bed count. The hospital also opened the Joseph S. Bruno Pediatric Heart Center, which includes a 20-room cardiovascular intensive care unit, two dedicated surgical suites, three heart and vascular catheterization labs, and four dedicated extracorporeal membrane oxygenation (ECMO) rooms. The floor connects directly via skywalk to the new UAB Women and Infants Center to provide quick and efficient access for the physicians and surgeons to their pediatric patients, as well as for the immediate transport of newborns requiring specialized care for congenital heart ailments. At the cornerstone of the Bruno Heart Center is its innovative pediatric hybrid catheterization suite, the only one of its kind in the state of Alabama. The hybrid cath lab is equipped with $3 million worth of state-of- the-art technology that allows it to be immediately converted to a cardiovascular surgical suite, eliminating the need to bring children out of anesthesia for a second procedure in a different room.

Child Health Research Unit (CHRU)

The Child Health Research Unit (CHRU) was developed to provide a platform to improve our understanding of child health and childhood disease pathogenesis, and to accelerate the development of new treatments for diseases that are manifested in childhood.  Its outpatient research unit is located on the 3rd floor of Dearth Tower, which is part of Children’s of Alabama on the UAB campus. With a recent $400 million expansion, Children’s is one of the largest and busiest centers for child health care and the third largest pediatric hospital in the US. The unit includes six well-equipped exam rooms, a triage room, a specimen processing laboratory with centrifuge and freezer, office and conference space, and workspace with monitors. The unit is separate from the outpatient clinical care areas, which ensures that study subjects are separated from clinical care activities. The CHRU provides UAB child health researchers with the infrastructure to implement and conduct studies. The hours of utilization are flexible and can include after-hour visits.

COA Research Pharmacy

Children's of Alabama Pharmacy department is committed to excellence in the provision of pharmaceutical care including medication delivery, decisions about medication selection, dosages, routes and methods of administration, medication therapy monitoring, and the provision of other medication-related information and counseling to individual patients.  The Investigational department provides services for inpatients and clinic patients.  Its pediatric-trained pharmacists provide investigational drug support and drug information services to the patients and health care professionals within the health system. 

Investigational (Study) Drug Policy: The pharmacy department is responsible for establishing specific procedures regarding the control and usage of medications related to clinical research in order to ensure the safety of research subjects.  These procedures comply with UAB’s Institutional Review Board.  Investigational medications require a complete order by an authorized prescriber.  All investigational drugs dispensed to enrolled study patients seen at COA are stored separately from other drugs in an area of limited access and are dispensed from the Pharmacy Department.  All inpatient and outpatient medications must be clearly labeled as required in the procedural guidelines.  The pharmacy is responsible for reviewing protocols to ensure they are in accordance with hospital policy.  Pharmacists dispense investigational drugs only after receiving written confirmation that a subject has properly signed an IRB-approved informed consent and is a currently enrolled study patient either from the PI or his/her designee.  Investigational drugs are dispensed only upon receipt of an order or prescription authorized by a PI and after checking if the dose is correct per protocol guidelines.  Pharmacists are also responsible for maintaining accurate records, storing drugs according to manufacturer’s specifications, and disposing of unused materials or returning unused materials to the sponsor in accordance with instructions.  Pharmacists also provide the identity codes for blinded investigational drugs, if authorized by the study sponsor and/or protocol if necessity demands.  Upon completion of a study, the study pharmacist will dispose of or return unused materials to the sponsor in accordance with instructions from the protocol, PI, study sponsor, or Drug Enforcement Administration, as appropriate, and will store all pertinent records as deemed appropriate by designated agencies and the drug sponsor and/or sponsor representative.

Laboratory Space

Department of Pediatrics Molecular Diagnostic Laboratory

The Molecular Diagnostic Laboratory is housed on the 7th floor of the Children’s Hospital Tower, which is connected by a walkway to the Children’s Harbor Building. The laboratory shares some common areas with the Diagnostic Virology Laboratory. The lab is arranged to optimize the performance of molecular assays in that it contains several areas that are dedicated to the preparation of PCR specimens and reagents while other areas are restricted to post-amplification procedures. Specifically, the areas for PCR testing are: (1) 220 sq ft specimen processing room. This room contains 3 nucleic acid extraction robots, Qiagen EZ1 Advanced XL (14 specimens per run), a Biomieux Easy Mag (24 specimens per run), and a Roche MagnaPure extractor (96 specimens per run). This room also has storage for extraction reagents, a refrigerator, freezer and chemical hood. (2) 165 sq. ft. reagent preparation room. This room a 16 cu ft freezer, refrigerator and space for reagents, plastic disposables, PCR positive displacement pipettes and a chemical hood. (3) 90 sq ft target-reagent room which contains a PCR Workstation hood, a 6 cu. ft. refrigerator , freezer and all the disposables necessary for reagent and specimen handling. (4) 2 bays which are approximately 450 sq ft for gel-based PCR amplification and post amplification procedures. This space contains two ABI GeneAmp 2700 96-well PCR System, two ABI GeneAmp 9700 Thermal cyclers. The post-amplification gel detection bay contains 3 agarose gel electrophoresis chambers with power supplies, and all the equipment and reagents necessary to prepare and run gels. One bay in the 6-bay large lab, 1000 sq ft, contains the real time PCR instruments, two ABI 7300 Real Time PCR Systems and an ABI 7500 Real Time PCR System. The 3 ABI Real Time instruments are run by dedicated Dell computers (Windows XP). The laboratory also contains a GeneMark eSensor instrument for highly multiplexed panels and is run by a dedicated Dell computer. Data from all instruments is backed up daily onto an external volume maintained by the Department of Pediatrics IT Department. In addition, there is a freezer storage room (240 sq ft) containing six 24 cu ft ultra-cold freezers (-80˚C). There are six additional 22 cu ft ultra-cold freezers housed in the main laboratory. Also in the large lab, there are 2 refrigerators, 2 water-jacketed CO2 incubators, two IEC intermediate speed centrifuges and two -20 C freezers. The lab also occupies 3 bays (650 sq ft) in another laboratory shared with the Diagnostic Virology Lab. Two bays in this area are for shipping and receipt of specimens. There is a laptop computer with bar code reader, various shipping containers, vials and other disposables which are used to construct specimen collection kits to be used at outlying labs. There are two addition rooms off this lab (60 sq ft), one contains the digital camera, UV illuminator and a Kodak 1D Image Analysis system which runs from a dedicated Dell computer which is also backed up to an external hard drive. The second small room contains fluorescent and light microscopes. Common areas shared with the Diagnostic Virology lab include another 6 bay lab, 1000 sq ft general purpose lab, walk-in refrigerator, walk-in incubator and walk-in freezer, kitchen area with autoclaves. For tissue culture and viral isolation, there are three Class 3 biosafety hoods, centrifuges, disposables, and inverted microscope for reading plates and shell vials. There are three offices in or near the lab occupied by the director, lab supervisor and head technician. All offices have Dell computers (Windows XP), Microsoft Office software, multiple printers and fax machines. These computers are linked to the internet and to the Pediatric server which hosts and backs-up all study specific databases.

Department of Pediatrics Molecular Resistance Laboratory

The Molecular Resistance Laboratory is located within the Children’s Harbor Building on the UAB campus. There are laboratories on two floors of the building and the entrance to both floors requires card keys issued by UAB security, which both monitors and restricts access to the facility. All doors to individual laboratories are locked at all times with numeric locks to limit access. The main laboratory is an eight module laboratory includes three offices with sit down space for eight Research Assistants and two Research Associates. A separate room secure with numeric locks is adjacent to the laboratory for the controlled storage of research materials. Associated administrative/data support offices are also located on the floor adjacent to the laboratory. A separate room secure with numeric locks is adjacent to the laboratory for the controlled storage of research materials. There is a two module BSL3 Suite on the ground floor of the building. A separate office with sit-down space for three Research Associates is located adjacent to the laboratory. Both laboratories are operational and fully equipped with major equipment required for the performance of Task Orders including class II biosafety cabinets, incubators, ultralow freezers, automated liquid handling systems, microplate readers and analytical balances. Standard minor equipment is also present in the laboratory including an three ABI Real Time thermal cyclers, luminometers, microscopes, centrifuges, water baths, and refrigerators. All computers in the laboratory including those that interface with major equipment are supplied and administered by the Department of Pediatrics IT Division. At present, 15 computers are in use for data management, report writing or controlling equipment. All data is stored on secure volumes administered by IT and they are backed up on a daily basis and archived. Core equipment in Children’s Harbor Building include autoclaves, glassware washers, ultracentrifuges, cold rooms, dark rooms, image capturing equipment, scintillation counters, and fluorescent and confocal microscopes. Additional services are available through the Comprehensive Cancer Center and include a core DNA sequencing facility, a proteomics facility, electron microscopy and bioinformatics services.

UAB Hospital

The centerpiece of UAB’s clinical enterprise, UAB Hospital is located in Birmingham’s Medical District.  In the midst of UAB’s major research centers and clinics, the 1,157-licensed-bed medical and surgical facility is among the 20 largest and best equipped in the nation.  Encompassing five city blocks, 13 major buildings and 2.1 million square feet of space, it excels in the areas of emergency care transport, heart and kidney diseases, cancer, spinal cord injuries, diabetes, arthritis, organ transplantation, and cardiac surgery.  It has approximately 72,000 admissions each year, providing patients with a complete range of primary and specialty care services and the most up-to-date treatments and innovations in health care. UAB Hospital performed 22,144 annual inpatient and 15,932 outpatient surgeries, and its emergency room had 83,433 visits.    UAB Hospital is ranked nationally in 9 adult specialties and considered high-performing in 4 other adult specialties.  It has also been designated a Magnet facility three times.  Because it is at the forefront of medical innovation, UAB Hospital draws referrals from community hospitals throughout Alabama, as well as many other states and a number of foreign countries.

The Women and Infants Center

The UAB Women and Infants Center is a world-class health care facility dedicated solely to the care of women and infants. UAB is the only hospital in the state where high-risk maternal and fetal physicians are available in-house 24 hours a day, every day of the year.  It also provides the area's only 24/7 Maternity Evaluation Unit for assessment of any pregnancy questions that might arise at gestational age of 16 weeks or greater.  The 400,000-square-foot-hospital is one of the first in the Southeast with all private neonatal intensive care nursery and continuing care nursery rooms. It also offers private labor, antepartum, postpartum, and gynecology patient rooms. The private room design enhances maternal, family, and infant bonding. Specialized isolation rooms and rooms designed for twins and triplets further enhance the family atmosphere. UAB’s highly-trained and compassionate physicians, nurses and other health professionals utilize advanced services and sophisticated state-of-the-art medical technology dedicated to the care of healthy and high-risk pregnant women, healthy and high-risk newborns, and women receiving care for a variety of gynecological challenges, including gynecological cancers.


The Institute for Cancer Outcomes and Survivorship

Each year, more people with cancer are surviving the disease. Approximately 65% of those diagnosed with cancer are expected to live at least five years after diagnosis and there will be 18 million cancer survivors by the year 2020.

Now that the number of cancer survivors is growing, the next challenge is addressing the long-term impact of cancer and its treatment. At least two thirds of cancer survivors have one or more chronic health conditions and about one third suffer from a life-threatening illness that is a direct consequence of their treatment. These health problems may include fatigue, nerve damage, memory loss, heart and kidney failure, blurred vision, lung disease and second cancers. Survivors are also more likely to suffer from emotional issues such as post-traumatic stress disorder, depression and anxiety.  While there have been tremendous advances in treating and curing cancer, the resulting improvements in survival rates are not enjoyed equally by all. In fact, there are significant differences in survival along racial, ethnic, and socioeconomic lines.  Finally, a diagnosis of cancer imparts a heavy economic burden on the patient and their family. This is in the form of lost wages for patients and their caregivers as well as out of pocket costs for the cancer treatment.

In order to meet the needs of cancer survivors, UAB has founded the Institute for Cancer Outcomes and Survivorship to better understand the long-term effects of cancer treatment on the overall health and well-being of survivors. It also seeks to design interventions and therapies that will help survivors to both survive and thrive.

Services provided by the Institute for Cancer Outcomes and Survivorship include:

Clinical Care: The Institute provides comprehensive, long-term care for cancer survivors, including medical care, psychological counseling, nutritional advice and health care education. Institute personnel work in collaboration with the patient’s primary care physician and oncologist in order to ensure that the unique medical needs of cancer survivors are met.

Specialized Support Services: In order to help survivors successfully return to their lives after cancer treatment, the Institute provides services such as support groups with other cancer survivors, weekend retreats to discuss survivorship issues, vocational counseling to help survivors return to work and physical/occupational therapy. It also provides patient advocacy services to help patients manage work, school, and insurance issues.

Education: Each survivor receives personalized health information based on diagnosis, treatment and current medical conditions, empowering them to take steps to optimize their health. The personalized health information is also provided to the survivor’s primary care physician so that they can address the survivor’s unique needs. Other educational initiatives include a patient resource library, educational seminars for survivors, and educational outreach programs for the community.

Research: A critical component of the Institute’s mission is to understand the underlying cause(s) of the health issues faced by cancer survivors through the conduct of cutting edge research by outstanding researchers within the Institute and in partnership with the cancer survivors. Research results will be used to develop therapies to improve the health and well-being of cancer survivors across all walks of life.

Healthcare Professional Training: The Institute will offer a post-graduate fellowship program in cancer survivorship for clinicians and researchers planning careers in the cancer survivorship field. It will also offer continuing medical education on cancer survivorship issues for healthcare professionals. As a result, it will improve care for cancer survivors across the nation.

University-Wide Interdisciplinary Research Centers (UWIRCs)

University-Wide Interdisciplinary Research Centers provide a framework for research and training. These multidisciplinary centers are open to all investigators with interests consistent with the mission of the given center. The centers assist in coordinating thematically-oriented efforts for extramural grants and contracts, in developing center-associated core facilities and in integrating enrichment programs that are important trainee resources. Centers require sponsorship from at least three UAB schools, substantive interdisciplinary faculty involvement; contribution to the intellectual environment in order to enhance faculty and student recruitment, development, and retention; an extramural financial base to support center and core activities; internal and external review processes to ensure quality and productivity; and leadership in the integration of research and service including community outreach or partnerships. Through a competitive review process, the Deans of sponsoring Schools and the Provost provide modest funds for research cores, pilot and feasibility studies and selective enrichment activities.

UAB Center for Clinical and Translational Science (CCTS)

The mission of the UAB CCTS is to address disparities and diseases disproportionately represented within the Deep South as it speeds the translation of research to improve human health. The CCTS and its Partner Network are committed to increasing research capacity, accelerating research processes, developing and supporting excellence in the research workforce and providing creative, innovative approaches to major health and health care delivery challenges. The CCTS offers access to a number of resources and capacities through its Research Commons and Training Academy, including access to core capacities such as clinical services; sample processing; informatics; UAB biorepositories; biostatistics, epidemiology and research design; comparative effectiveness research; exercise medicine; and human to model systems. It also includes a significant training and career development component. Through the Research Commons, investigators can access research-related services and resources available at UAB and our Partner Network institutions. The Commons provides individualized assistance to all investigators, from trainees to full professors. CCTS personnel direct investigators to appropriate services and resources and help identify related opportunities. They facilitate scientific connections between investigators and research capacities and among investigators to promote scientific interactions. One resource, especially useful to junior faculty and trainees, is the Panels Program. Panels provide consultation in early phase project design, grant proposal development, evaluation and revision of unfunded grant proposals, implementation of research protocols, and interpretation and or dissemination of experimental results.  To assist with institutional awards, the Training Academy provides a webpage with resources for training grant directors, including a library of successful T32 applications and information on training in the Responsible Conduct of Research. For individual career development awards, the CCTS also offers assistance with personal statements and the career development plans – with the option of Panels to strengthen the scientific content. In addition, it provides training in specific content areas – most notably informatics, drug discovery, and biostatistics methodology. Informatics offers lectures and seminars, as well as an annual Summer Seminar Series. The Alabama Drug Discovery Alliance (ADDA), in collaboration with the CCTS, offers an annual Drug Discovery Seminar Series. Biostatistics methodology lectures have been provided, specifically targeting pilot program applicants. These lectures are archived and available through the CCTS website. Other training has also been provided related to biorepositories, data management, biostatistics, etc.

UAB Comprehensive Cancer Center (CCC)

The UAB Comprehensive Cancer Center (CCC) is the cancer program-coordinating hub of the UAB Medical Center. UAB received initial funding for an NCI Cancer Center Planning Grant in 1970 and its first Cancer Center Core Support grant in 1972. The UAB CCC has been continuously funded by the NCI since its initial funding and is one of the original cancer centers funded. In its latest renewal the CCC officially became a consortium with the HudsonAlpha Biomedical Institute located in Hunstville, AL. Currently, the Cancer Center has 277 members representing 8 Schools and 30 Departments at UAB and HudsonAlpha. Combined, its members have annual total extramural funding of ~$125 million in total costs. The Cancer Center Director has stewardship of 146,817 net square feet of research and administrative space within the Wallace Tumor Institute, with 105,000 net square feet used to house the UAB CCC. Wallace Tumor Institute recently completed a $35 million renovation that provides an additional 72,000 square feet of modern state-of-the-art wet laboratory and laboratory support space plus 33,000 square feet of administrative space. This CCC houses six major scientific programs: Immunology, Inflammation and Immuno-therapeutics; Cancer Cell Biology; Experimental Therapeutics; Neuro-Oncology; Cancer Chemo-Prevention; and Cancer Control & Population Science. The UAB CCC provides access to high-end equipment and technical expertise for cancer investigators. The Cancer Center Core Support Grant currently provides funding for the following 12 shared facilities: 1) Biostatistics and Bioinformatics, 2) Clinical Protocol and Data Management, 3) Community Recruitment and Retention, 4) Comprehensive Genomics, 5) High Resolution Imaging, 6) Human Imaging, 7) Mass-Spectrometry/Proteomics, 8) Microbiome 9) Pre-Clinical Imaging, 10) Structural Biology (NMR + X-Ray Crystallography) 11) Tissue Procurement, and 12) Transgenic Animal/Embryonic Stem Cell.