Selected CD154 regulation & SLE publications


NF-ATc1 levels are increased in murine and human lupus T cells: comment on the article by Kyttaris et al. Mehta J. Cron RQ. Arthritis Rheum. 2012 Apr;64(4):1294; author reply 1294. PMID: 22034015.

Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis.
Mehta J, Genin A, Brunner M, Scalzi LV, Mishra N, Beukelman T, Cron RQ. Arthritis Rheum. 2010 Aug;62(8):2499-509.PMID: 20506525.

A T-cell-specific CD154 transcriptional enhancer located just upstream of the promoter. Brunner M, Zhang M, Genin A, Ho IC, Cron RQ. Genes Immun. 2008 Oct;9(7):640-9. Epub 2008 Aug 21.PMID: 18719603.

Neither cell-surface nor soluble CD154 levels are associated with coronary artery disease in systemic lupus erythematosus. von Feldt JM, Latif S, Genin A, Cron RQ. J Rheumatol. 2008 Feb;35(2):359-60. No abstract available. PMID: 18260168.

Homocysteine levels and disease duration independently correlate with coronary artery calcification in patients with systemic lupus erythematosus. Von Feldt JM, Scalzi LV, Cucchiara AJ, Morthala S, Kealey C, Flagg SD, Genin A, Van Dyke AL, Nackos E, Chander A, Gehrie E, Cron RQ, Whitehead AS. Arthritis Rheum. 2006 Jul;54(7):2220-7.PMID: 16802358.

Early growth response-1 is required for CD154 transcription. Cron RQ, Bandyopadhyay R, Genin A, Brunner M, Kersh GJ, Yin J, Finkel TH, Crow MK. J Immunol. 2006 Jan 15;176(2):811-8.PMID: 16393964.

Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cell activation. Jullien P, Cron RQ, Dabbagh K, Cleary A, Chen L, Tran P, Stepick-Biek P, Lewis DB. Int Immunol. 2003 Dec;15(12):1461-72.PMID: 14645155.

CD154 transcriptional regulation in primary human CD4 T cells. Cron RQ. Immunol Res. 2003;27(2-3):185-202. Review. PMID: 12857968.

Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression. Hamilton BJ, Genin A, Cron RQ, Rigby WF. Mol Cell Biol. 2003 Jan;23(2):510-25. Erratum in: Mol Cell Biol. 2003 Sep;23(17):6338. PMID: 12509450.

A T cell-specific enhancer of the human CD40 ligand gene. Schubert LA, Cron RQ, Cleary AM, Brunner M, Song A, Lu LS, Jullien P, Krensky AM, Lewis DB. J Biol Chem. 2002 Mar 1;277(9):7386-95. Epub 2001 Dec 19.PMID: 11751888.

The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation. Schubert LA, King G, Cron RQ, Lewis DB, Aruffo A, Hollenbaugh D. J Biol Chem. 1995 Dec 15;270(50):29624-7.PMID: 8530342.