Professor of Clinical Pharmacology
Associate Scientist, Comprehensive Cancer Center
Associate Scientist, Center for AIDS Research
BS in Biology, University of Minnesota-Duluth; BS in Pharmacy, College of Pharmacy, Univeristy of Minnesota; Doctor of Pharmacy (Pharm.D.), College of Pharmacy, University of Minnesota; Post-Doctoral Research Fellowship; Infectious Diseases, Pharmacokinetics/Pharmacodynamics; College of Pharmacy, University of Minnesota
Honors and Awards:
American Society for Microbiology Fellow Travel Grant Award to attend the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA; American Society for Microbiology Fellow Travel Grant Award to attend the 2nd National Conference on Human Retroviruses and Related Infections, Washington, DC; Miles Pharmaceuticals Research Fellowship Award in Infectious Disease Therapeutics; Outstanding Young Men of America
A primary goal of my lab is to develop assays for the quantitation of antiviral and antiretroviral drugs from intracellular and human plasma specimens. I also participate in multicenter clinical trials designed to assess the absorption and disposition of antiviral and antiretroviral drugs. The lab then quantitates these compounds from samples collected from patients in these studies and we perform pharmacokinetic and/or pharmacodynamic analyses in an attempt to better understand how these drugs should be used in adult and pediatric patient populations.
Acosta EP, Henry K, Baken L, Page LM, Fletcher CV. Indinavir Concentrations and Antiviral Effect. Pharmacotherapy 19:708-712, 1999.
Fletcher CV, Acosta EP, Henry K, Page LM, Gross CR, Kawle SP, Remmel RP, Erice A, Balfour Jr., HH. Concentration-Controlled Zidovudine Therapy. Clin Pharmacol Ther 64:331-338, 1998.
Balfour Jr HH, Fletcher CV, Erice A, Henry K, Acosta EP, Smith S, Holm M, Boivin G, Shepp D, Crumpacker C, Eaton C, Martin-Munley S.. Effect of foscarnet on quantities of cytomegalovirus and human immunoodeficiency virus in blod of persons with AIDS. Antimicrobial Agents and Chemotherapy 40:2721-2726, 1996.
Acosta EP, Page LM, Fletcher CV. Clinical pharmacokinetics of zidovudine: An update. Clinical Pharmacokinetics 30:251-262, 1996.
Trachte GJ, Hook PJ, Kemp JR, Acosta EP, Zeigler RJ. Thromboxane synthesis and actions in isolated adrenergic nerve (pheochromocytoma-12) cells. Journal of Pharmacology and Experimental Therapeutics 247:43-46, 1988.
To contact Dr. Acosta:
1670 University Boulevard
Volker Hall 258
Birmingham, AL 35294-0019
Phone: (205) 934-2655
Fax: (205) 934-8240