Obesity and metabolic diseases are rising public health problems. Particularly, it is estimated that approximate 31-37% of adults are obese, and it is anticipated that approximately 65% population would be overweight or obese by 2030. Increasing evidence has demonstrated that obesity and metabolic diseases, including pre-diabetes, diabetes and dyslipidemia, are associated with mental illness such as depression and schizophrenia, and sleep and circadian dysfunction.

All of them are common human diseases with high mortality and morbidity. Stress and chronic inflammation are believed to be contributing to possible common pathophysiological mechanisms between obesity, metabolic diseases, mental illness and sleep disorders. However, it is not well defined of how to screen individuals with high risk for these disorders as well as how to prevent and treat people at the early stage for a better outcome. An important aspect for the researchers would be the understanding of the common origins of obesity, metabolic diseases, mental illness and sleep disorders, and the awareness of this quite common comorbidity, in order to improve the outcomes of these diseases.