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Division of Pulmonary, Allergy and Critical Care Medicine


Yan Z, Yang W, Parkitny L, Gibson SA, Lee KS, Collins F, Deshane JS, Cheng W, Weinmann AS, Wei H, Qin H, Benveniste EN. Deficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production. JCI Insight. 2019 Apr 2;5. pii: 126520. doi: 10.1172/jci.insight.126520.

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis. Cell Rep. 2018 Nov 13;25(7):1938-1952.e5. doi: 10.1016/j.celrep.2018.10.073.

Hough KP, Deshane J. Exosomes in Allergic Airway Diseases. Curr Allergy Asthma Rep. 2019 Mar 22;;19(5):26. doi: 10.1007/s11882-019-0857-3.

Chinta KC, Rahman MA, Saini V, Glasgow JN, Reddy VP, Lever JM, Nhamoyebonde S, Leslie A, Wells RM, Traylor A, Madansein R, Siegal GP, Antony VB, Deshane J, Wells G, Nargan K, George JF, Ramdial PK, Agarwal A, Steyn AJC. Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis. Cell Rep. 2018 Nov 13;25(7):1938-1952.e5. doi: 10.1016/j.celrep.2018.10.073.

Hough KP, Wilson LS, Trevor JL, Strenkowski JG, Maina N, Kim YI, Spell ML, Wang Y, Chanda D, Dager JR, Sharma NS, Curtiss M, Antony VB, Dransfield MT, Chaplin DD, Steele C, Barnes S, Duncan SR, Prasain JK, Thannickal VJ, Deshane JS. Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics. Sci Rep. 2018 Jul 9;8(1):10340. doi: 10.1038/s41598-018-28655-9.

Hough KP, Trevor JL, Strenkowski JG, Wang Y, Chacko BK, Tousif S, Chanda D, Steele C, Antony VB, Dokland T, Ouyang X, Zhang J, Duncan SR, Thannickal VJ, Darley-Usmar VM, Deshane JS.Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells. Redox Biol. 2018 Jun 25;18:54-64. doi: 10.1016/j.redox.2018.06.009. [Epub ahead of print]

Wang Y, Schafer CC, Hough KP, Tousif S, Duncan SR, Kearney JF, Ponnazhagan S, Hsu HC, Deshane JS. Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5. J Immunol. 2018 May 11. pii: ji1701069. doi: 10.4049/jimmunol.1701069. [Epub ahead of print]

Sharma NS, Wille KM, Athira S, Zhi D, Hough KP, Diaz-Guzman E, Zhang K, Kumar R, Rangarajan S, Eipers P, Wang Y, Srivastava RK, Rodriguez Dager JV, Athar M, Morrow C, Hoopes CW, Chaplin DD, Thannickal VJ, Deshane JS. Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipients. J Heart Lung Transplant. 2017 Jul 15. pii: S1053-2498(17)31898-3. doi: 10.1016/j.healun.2017.07.007. [Epub ahead of print]

Editorial: Mitchell, Alicia B., Glanville, Allan R. The Distal Airway Microbiome After Lung Transplantation: A Driver of Immune Regulation? J Heart Lung Transplant 2017 Nov 11. https://doi.org/10.1016/j.healun.2017.11.017

Hough KP, Chanda D, Duncan SR, Thannickal VJ, Deshane JS. Exosomes in Immunoregulation of Chronic Lung Diseases. Allergy. 2016 Nov 15. doi: 10.111/all.13086. [Epub ahead of print].

Schafer CC, Wang Y, Hough KP, Sawant A, Grant SC, Thannickal VJ, Zmijewski J, Ponnazhagan S, Deshane JS. Indoleamine 2,3-dioxygenase Regulates Anti-Tumor Immunity in Lung Cancer by Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment. Oncotarget. 2016 Sep 26. doi: 10.18632/oncotarget.12249 [Epub ahead of print.]

Srivastava RK, Li C, Wang Y, Weng Z, Elmets CA, Harrod KS, Deshane JS, Athar M. Activating transcription factor 4 underlies the pathogenesis of arsenic-mediated impairment of macrophage innate immune functions.Toxicol Appl Pharmacol.2016 Jul 23. pii: S0041-008X(16)30199-5. doi: 10.1016/j.taap.2016.07.015. PubMedPMID: 27461142

Larson-Casey JL,Deshane JS, Ryan AL, Thannickal VJ and A B Carter. Macrophage Akt1-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis. Immunity. 2016 Feb 22. pii: S1074-7613(16)00002-9. doi: 10.1016/j.immuni.2016.01.001. [Epub ahead of print]. PubMedPMID: 26921108

Liu RM, Eldridge S, Watanabe N, Deshane J, Kuo HC, Jiang C, Wang Y, Liu G, Schwiebert L, Miyata T, Thannickal VJ. Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L328-36. doi: 10.1152/ajplung.00217.2015. Epub 2015 Dec 23. PubMed PMID: 26702150

Cha HR, Lee JH, Hensel JA, Sawant AB, Davis BH, Lee CM, Deshane JS, Ponnazhagan S. Prostate cancer-derived cathelicidin-related antimicrobial peptide facilitates macrophage differentiation and polarization of immature myeloid progenitors to protumorigenic macrophages. Prostate. 2016 Feb 9. doi: 10.1002/pros.23155. [Epub ahead of print]. PubMedPMID: 26856684

Walker, M.M., Novak, L., King, J., Hale, J.Y., Ochs, M.M., Myers, L.E., Briles, D.E., and J. Deshane. PcpA promotes higher levels of infection and modulates recruitment of myeloid-derived suppressor cells during pneumococcal pneumonia. J Immunol. 2016 Mar 1;196(5):2239-48. doi: 10.4049/jimmunol.1402518. Epub 2016 Feb 1. PubMedPMID: 26829988 PMCID: PMC4761482 [Available on 2017-03-01]

Liu Z, Bone N, Jiang S, Park DW, Tadie JM, Deshane J, Rodriguez CA, Pittet JF, Abraham E, Zmijewski JW. AMP-activated protein kinase and Glycogen Synthase Kinase 3β modulate the severity of sepsis-induced lung injury. Molecular Medicine. 2015 Mol Med. 2015 Nov 30. doi: 10.2119/molmed.2015.00198. [Epub ahead of print]. PubMed PMID: 26650187 PMCID in progress.

Yu H, Liu Y,McFarland BC, Deshane JS, Hurst DR, Ponnazhagan S, Benveniste EN, Qin H. SOCS3 Deficiency in Myeloid Cells promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells. Cancer Immunol Res. 2015 Feb; pii: canimm.0004.2015. [Epub ahead of print]. PubMed PMID: 25649351 PMCID in progress.

Rohrbach TD, Jarboe JS, Anderson JC, Trummell HQ, Hicks PH, Weaver AN, Yang ES, Oster RA, Deshane JS, Steele C, Siegal GP, Bonner JA, Willey CD. Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity. Int. J. Oncol. 2015 March; 46(3): 1079-1088 doi: 10.3892/ijo.2014.2799. Epub 2014 Dec 17. PubMed PMID: 25524703 PMCID in progress.

Deshane JS, Redden DT, Zeng M, Spell MT, Zmijewski JW, Anderson JT, Deshane RJ, Gaggar A, Siegal GP, Abraham EA, Dransfield MT, DD Chaplin. Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease. J. Allergy and Clinical Immunology. 2015 Feb;135(2):413-424.e15 doi: 10.1016/j.jaci.2014. PubMed PMID: 25420684 PMCID: PMC 4323991 (Available on 2016-02-01).

Wang Y, Jin TH, Farhana A, Freeman J, Estell K, Zmijewski JW, Gaggar A, Thannickal V, Schwiebert L, Steyn AJC, Deshane JS. Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness. Laboratory Investigation. 2014 Dec;94(12):1312-1325. doi:10.1038/labinvest.2014.126. PubMed PMID:25365203 PMCID: PMC 4245361(Available on 2015/6/1).

Trevor JL & Deshane JS. Refractory Asthma: mechanisms, targets and therapy. Allergy 2014 Jul ;69(7):817-27, doi: 10.1111/all.12412. PubMed PMID: 24773466 PMCID: PMC 4279947.

Jiang S, Park DW, Tadie JM, Gregoire M, Deshane J, Pittet JF, Abraham E, Zmijewski JW. Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol. 2014 May 15;192(10):4795-803. doi: 10.4049/jimmunol.1302764. PubMed PMID: 24719460 PMCID: PMC4018664.

Sawant A, Schafer CC, Ponnazhagan S, Deshane J. The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer. Oncoimmunology 2014 Jan 1;3(1):e27401,doi:10.4161/onci.27401 PubMed PMID: 24711958 PMCID: PMC 3976979

Park DW, Jiang S, Tadie JM, Stigler WS, Gao Y, Deshane J, Abraham E, Zmijewski JW. Activation of AMPK enhances neutrophil chemotaxis and bacterial killing. Mol Med. 2013 Nov 8;19:387-98. doi: 10.2119/molmed.2013.00065. PubMed PMID: 24091934.PMCID:PMC3883969.

Srivastava RK, Li C, Chaudhary SC, Ballestas ME, Elmets CA, Robbins DJ, Matalon S, Deshane JS, Afaq F, Bickers DR, Athar M.  Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption.  Toxicol Appl Pharmacol 2013 Nov 1;272:879-87. doi: 10.1016/j.taap.2013.08.004. Epub 2013 Aug 14. PubMed PMID:23954561.

Alberti MO, Deshane JS, Chaplin DD, Pereboeva L, Curiel DT, Roth JC. A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism. Gene Ther. 2013 Jul;20(7):733-41. doi: 10.1038/gt.2012.91. Epub 2012 Nov 22. PubMed PMID: 23171918 PMCID: PMC3764611.

Sawant A, Schafer CC, Jin TH, Zmijewski J, Tse HM, Roth J, Sun Z, Siegal GP, Thannickal VJ, Grant SC, Ponnazhagan S, Deshane J. Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways. Cancer Res 2013 Nov 15;73:6609-20. doi: 10.1158/0008-5472. PubMed PMID: 24085788 PMCID:PMC3854493.

Sawant A, Deshane J, Jules J, Lee CM, Harris BA, Feng X, Ponnazhagan S. Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer. Cancer Res. 2013 Jan 15;73(2):672-82. doi: 10.1158/0008-5472.CAN-12-2202. Epub 2012 Dec 14. PubMed PMID: 23243021; PubMed Central PMCID: PMC3548966.

Tadie JM, Bae HB, Deshane JS, Bell CP, Lazarowski ER, Chaplin DD, Thannickal VJ, Abraham E, Zmijewski JW. Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism. Mol Med. 2012 May 9;18:659-68. doi: 10.2119/molmed.2011.00401. PubMed PMID: 22396017; PubMed Central PMCID: PMC3388138.

Bae HB, Zmijewski JW, Deshane JS, Zhi D, Thompson LC, Peterson CB, Chaplin DD, Abraham E. Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways. Am J Respir Cell Mol Biol. 2012 Jun;46(6):790-6. doi: 10.1165/rcmb.2011-0187OC. Epub 2012 Jan 26. PubMed PMID: 22281987; PubMed Central PMCID: PMC3380283.

Bae HB, Zmijewski JW, Deshane JS, Tadie JM, Chaplin DD, Takashima S, Abraham E. AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils. FASEB J. 2011 Dec;25(12):4358-68. doi: 10.1096/fj.11-190587. Epub 2011 Sep 1. PubMed PMID: 21885655; PubMed Central PMCID: PMC3236633.

Deshane J, Zmijewski JW, Luther R, Gaggar A, Deshane R, Lai JF, Xu X, Spell M, Estell K, Weaver CT, Abraham E, Schwiebert LM, Chaplin DD. Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness. Mucosal Immunol. 2011 Sep;4(5):503-18. doi: 10.1038/mi.2011.16. Epub 2011 Apr 6. PubMed PMID: 21471960; PubMed Central PMCID: PMC3694614.

Werner JL, Gessner MA, Lilly LM, Nelson MP, Metz AE, Horn D, Dunaway CW, Deshane J, Chaplin DD, Weaver CT, Brown GD, Steele C. Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection. Infect Immun. 2011 Oct;79(10):3966-77. doi: 10.1128/IAI.05493-11. Epub 2011 Aug 1. PubMed PMID: 21807912; PubMed Central PMCID: PMC3187263.

Anderson JT, Zeng M, Li Q, Stapley R, Moore DR 2nd, Chenna B, Fineberg N, Zmijewski J, Eltoum IE, Siegal GP, Gaggar A, Barnes S, Velu SE, Thannickal VJ, Abraham E, Patel RP, Lancaster JR Jr, Chaplin DD, Dransfield MT, Deshane JS. Elevated levels of NO are localized to distal airways in asthma. Free Radic Biol Med. 2011 Jun 1;50(11):1679-88. doi: 10.1016/j.freeradbiomed.2011.03.015. Epub 2011 Mar 16. Erratum in: Free Radic Biol Med. 2013 May;58:45. PubMed PMID: 21419218; PubMed Central PMCID: PMC3124865.

Complete Publications Listing

Book Chapters

J. Deshane and Thannickal, V.J. Fifth Edition Fishman’s Pulmonary Diseases and Disorders, Volume 1, : Chapter 27: Redox Signaling and Oxidative Stress in Lung Diseases, Edited by Jack A. Elias,M.D., Robert M. Kotloff, M.D., Allan I. Pack, Ph.D., Jay A. Fishman, M.D., Robert M. Senior, M.D. Mc Graw Hill Education, 2015.

H. Kim, S. Eliuk, J. Deshane, S. Meleth, T. Sanderson, A. Pinner, G. Robinson, L. Wilson, M. Kirk and S. Barnes. 2D Gel Proteomics. An approach to study Age-Related Differences in Protein Abundance or Isoform Complexity in Biological Samples. Methods in Molecular Biology: Biological Aging: Methods and Protocols, Chapter 24, Edited by : T.O.Tollefsbol @ Humana Press Inc., Totowa, NJ. 2007.

H. Kim, S. Eliuk, J. Deshane, S. Barnes, S. Meleth . Nutriproteomics Approach to Understanding Dementia-Relevant Brain Protein Changes in Response to Grape Seed Extract, a Dietary Antioxidant: Oxidative stress and age-related neurodegeneration. Yuan Luo, Lester Packer, 2005.

J. Deshane, R. Alvarez, G.P. Siegal. Eradication of c-erbB-2 positive ovarian cancer cells mediated by intracellular expression of anti-erbB-2 sFv. In: Bartlett, J.M.S.(Ed.): Methods in Molecular Medicine: Ovarian Cancer: Methods and Protocols, Humana Press, Totowa, N.J. 2000.

M.N. Barnes, M. Wang, J. Deshane, G.P. Siegal, T.J. Vanderkwaak, R.D. Alvarez, and D.T. Curiel. In vivo efficacy of an anti-erbB-2 intracellular single chain antibody in combination with cisplatin in a murine model In: Sharp, F., Blackett, T., Berek, J., and Bast, R. (eds.). Ovarian Cancer 5, isis Medical Media, Oxford, Chapter 25, pp.283-291, 1998.