2019 Publications

October 2019

Oelsner EC, Balte PP, Bhatt SP, Cassano PA, Couper D, Folsom AR, Freedman ND, Jacobs DR Jr, Kalhan R, Mathew AR, Kronmal RA, Loehr LR, London SJ, Newman AB, O'Connor GT, Schwartz JE, Smith LJ, White WB, Yende S.Lancet Respir Med. 2019 Oct 9. pii: S2213-2600(19)30276-0. doi: 10.1016/S2213-2600(19)30276-0. [Epub ahead of print]Lung function decline in former smokers and low-intensity current smokers: a secondary data analysis of the NHLBI Pooled Cohorts Study.

Kulkarni T, Yuan K, Tran-Nguyen TK, Kim YI, de Andrade JA, Luckhardt T, Valentine VG, Kass DJ, Duncan SR.PLoS One. 2019 Oct 4;14(10):e0221905. doi: 10.1371/journal.pone.0221905. eCollection 2019.Decrements of body mass index are associated with poor outcomes of idiopathic pulmonary fibrosis patients.

Hodges AL, Konicki AJ, Talley MH, Bordelon CJ, Holland AC, Galin FS.J Am Assoc Nurse Pract. 2019 Oct 3. doi: 10.1097/JXX.0000000000000327. [Epub ahead of print]Competency-based education in transitioning nurse practitioner students from education into practice.

Janz DR, Casey JD, Semler MW, Russell DW, Dargin J, Vonderhaar DJ, Dischert KM, West JR, Stempek S, Wozniak J, Caputo N, Heideman BE, Zouk AN, Gulati S, Stigler WS, Bentov I, Joffe AM, Rice TW; PrePARE Investigators; Pragmatic Critical Care Research Group.Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial. Lancet Respir Med. 2019 Oct 1. pii: S2213-2600(19)30246-2. doi: 10.1016/S2213-2600(19)30246-2. [Epub ahead of print]

September 2019

Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, Burgel PR, Tullis E, Castaños C, Castellani C, Byrnes CA, Cathcart F, Chotirmall SH, Cosgriff R, Eichler I, Fajac I, Goss CH, Drevinek P, Farrell PM, Gravelle AM, Havermans T, Mayer-Hamblett N, Kashirskaya N, Kerem E, Mathew JL, McKone EF, Naehrlich L, Nasr SZ, Oates GR, O'Neill C, Pypops U, Raraigh KS, Rowe SM, Southern KW, Sivam S, Stephenson AL, Zampoli M, Ratjen F.Lancet Respir Med. 2019 Sep 27. pii: S2213-2600(19)30337-6. doi: 10.1016/S2213-2600(19)30337-6. [Epub ahead of print]The future of cystic fibrosis care: a global perspective.

Rana T, Jiang C, Liu G, Miyata T, Antony V, Thannickal VJ, Liu RM.Am J Respir Cell Mol Biol. 2019 Sep 12. doi: 10.1165/rcmb.2019-0071OC. [Epub ahead of print]PAI-1 Regulation of TGF-β1-induced ATII Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages.

Hartley B, Criner GJ, Dransfield MT, Halpin DMG, Han MK, Jones CE, Kilbride S, Lange P, Lipson DA, Lomas DA12, Martin N, Martinez FJ, Singh D, Wise RA, Lettis S.Eur Respir J. 2019 Sep 5;54(3). pii: 1900634. doi: 10.1183/13993003.00634-2019. Print 2019 Sep. Misinterpretation of time-to-first event curves can lead to inappropriate treatment.

Oates GR, Niranjan SJ, Ott C, Scarinci IC, Schumann C, Parekh T, Dransfield MT.J Cardiopulm Rehabil Prev. 2019 Sep;39(5):344-349. doi: 10.1097/HCR.0000000000000436.Adherence to Pulmonary Rehabilitation in COPD: A QUALITATIVE EXPLORATION OF PATIENT PERSPECTIVES ON BARRIERS AND FACILITATORS.

Gu L, Larson Casey JL, Andrabi SA, Lee JH, Meza-Perez S, Randall TD, Carter AB.Redox Biol. 2019 Sep;26:101307. doi: 10.1016/j.redox.2019.101307. Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis.

August 2019

Bhatt SP. Ann Am Thorac Soc. 2019 Aug;16(8):975-977. doi: 10.1513/AnnalsATS.201903-231ED.Imaging Small Airway Disease: Probabilities and Possibilities.

Maselli DJ, Bhatt SP, Anzueto A, Bowler RP, DeMeo DL, Diaz AA, Dransfield MT, Fawzy A, Foreman MG, Hanania NA, Hersh CP, Kim V, Kinney GL, Putcha N, Wan ES, Wells JM, Westney GE, Young KA, Silverman EK, Han MK, Make BJ. Chest. 2019 Aug;156(2):228-238. doi: 10.1016/j.chest.2019.04.135. Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study.

He C, Larson-Casey JL, Davis D, Hanumanthu VS, Longhini ALF, Thannickal VJ, Gu L, Carter AB. JCI Insight. 2019 Aug 22;4(16). pii: 126551. doi: 10.1172/jci.insight.126551.NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis.

Mkorombindo T, Dransfield MT. Respirology. 2019 Aug 21. doi: 10.1111/resp.13683. [Epub ahead of print]COPD exacerbations and MACE: More than a chance encounter?

McCormick JP, Weeks CG, Rivers NJ, Owen JD, Kelly DR, Rowe SM, Solomon GM, Woodworth BA, Cho DY. Int Forum Allergy Rhinol. 2019 Aug 20. doi: 10.1002/alr.22414. [Epub ahead of print]Prevalence of chronic rhinosinusitis in bronchiectasis patients suspected of ciliary dyskinesia.

Bhatt SP, Dransfield MT.Am J Respir Crit Care Med. 2019 Aug 6. doi: 10.1164/rccm.201907-1486LE. [Epub ahead of print]Reply to: Video Telehealth and Pulmonary Rehabilitation: Need for a Better Understanding.

Mkorombindo T, Dransfield M. Lancet Respir Med. 2019 Aug;7(8):647-648. doi: 10.1016/S2213-2600(19)30179-1. Epub 2019 May 20.Eosinophil-guided treatment of COPD exacerbations: unfinished business.

July 2019

Xing D, Wells JM, Giordano SS, Feng W, Gaggar A, Yan J, Hage FG, Li L, Chen YF, Oparil S. J Appl Physiol (1985). 2019 Aug 1;127(2):444-456. doi: 10.1152/japplphysiol.00587.2018. Induced pluripotent stem cell-derived endothelial cells attenuate lipopolysaccharide-induced acute lung injury.

Washko GR, Colangelo LA, Estépar RSJ, Ash SY, Bhatt SP, Okajima Y, Liu K, Jacobs, Iribarren C, Thyagarajan BT, Lewis CE, Kumar R, Han MK, Dransfield MT, Carnethon, Kalhan R.Am J Med. 2019 Jul 29. pii: S0002-9343(19)30600-X. doi: 10.1016/j.amjmed.2019.06.049. [Epub ahead of print]Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study.

Bhatt SP, Dransfield MT.Am J Respir Crit Care Med. 2019 Jul 25. doi: 10.1164/rccm.201907-1287LE. [Epub ahead of print]Reply to: Not all Home-Based Exercise Programs are Home-Based Pulmonary Rehabilitation Programs.

Lyu X, Hu M, Peng J, Zhang X, Sanders YY.Ther Adv Chronic Dis. 2019 Jul 18;10:2040622319862697. doi: 10.1177/2040622319862697. eCollection 2019.HDAC inhibitors as antifibrotic drugs in cardiac and pulmonary fibrosis.

Rusanov V, Fridman V, Wille K, Kramer MR.Transplant Proc. 2019 Jul - Aug;51(6):2029-2034. doi: 10.1016/j.transproceed.2019.04.036. Lung Transplantation for Cystic Fibrosis and Non-cystic Fibrosis Bronchiectasis: A Single-Center Experience.

Johns JD, Rowe SM.BMC Gastroenterol. 2019 Jul 11;19(1):123. doi: 10.1186/s12876-019-1044-7.The effect of CFTR modulators on a cystic fibrosis patient presenting with recurrent pancreatitis in the absence of respiratory symptoms: a case report.

June 2019 Patel NM, Kulkarni T, Dilling D, Scholand MB; Interstitial and Diffuse Lung Disease Network Steering Committee.Chest. 2019 Jun 29. pii: S0012-3692(19)31240-1. doi: 10.1016/j.chest.2019.05.028. [Epub ahead of print]Preoperative Evaluation of Patients With Interstitial Lung Disease.

Bhatt SP, Balte PP, Schwartz JE, Cassano PA, Couper D, Jacobs DR Jr, Kalhan R, O'Connor GT, Yende S, Sanders JL, Umans JG, Dransfield MT, Chaves PH, White WB, Oelsner EC.JAMA. 2019 Jun 25;321(24):2438-2447. doi: 10.1001/jama.2019.7233.Discriminative Accuracy of FEV1:FVC Thresholds for COPD-Related Hospitalization and Mortality.

Rangarajan S, Thannickal VJ.Am J Respir Crit Care Med. 2019 Jun 17. doi: 10.1164/rccm.201906-1101ED. [Epub ahead of print] Remember Me? The Bone Marrow in Pulmonary Fibrosis.

Barnes J, Krick S.Ann Am Thorac Soc. 2019 Jun;16(6):674-675. doi: 10.1513/AnnalsATS.201901-095ED.How to Detect Tobacco-related Vasculopathy: Are We There Yet?

Bernard K, Thannickal VJ.Methods Mol Biol. 07 Jun 2019;1982:487-496. doi: 10.1007/978-1-4939-9424-3_29. NADPH Oxidases and Aging Models of Lung Fibrosis.

May 2019

McDonald MN, Wouters EFM, Rutten E, Casaburi R, Rennard SI, Lomas DA, Bamman M, Celli B, Agusti A, Tal-Singer R, Hersh CP, Dransfield M, Silverman EK.Respir Res. 2019 May 22;20(1):100. doi: 10.1186/s12931-019-1073-3.It's more than low BMI: prevalence of cachexia and associated mortality in COPD.

Chanda D, Thannickal VJ.Am J Respir Cell Mol Biol. 2019 May 15. doi: 10.1165/rcmb.2019-0153ED. [Epub ahead of print]Modeling Fibrosis in 3D Organoids Reveals New Epithelial Restraints on Fibroblasts.

Parekh TM, Wu C, McClure LA, Howard VJ, Cushman M, Malek AM, Harrington KF, Cherrington AL, Dransfield MT, Bhatia S. BMJ Open. 2019 May 10;9(5):e027175. doi: 10.1136/bmjopen-2018-027175.Determinants of cigarette smoking status in a national cohort of black and white adult ever smokers in the USA: a cross-sectional analysis of the REGARDS study.

Gulati S, Wells JM, Urdaneta GP, Balestrini K, Vital I, Tovar K, Barnes JW, Bhatt SP, Campos M, Krick S.Int J Mol Sci. 2019 May 9;20(9). pii: E2292. doi: 10.3390/ijms20092292.Fibroblast Growth Factor 23 is Associated with a Frequent Exacerbator Phenotype in COPD: A Cross-Sectional Pilot Study.

Towards eradication of chronic obstructive pulmonary disease: a Lancet Commission. Lancet. 2019 May 4;393(10183):1786-1788. doi: 10.1016/S0140-6736(19)30950-X.

April 2019

Surolia R, Li FJ, Wang Z, Li H, Dsouza K, Thomas V, Mirov S, Perez-Sala D, Athar M, Thannickal V, Antony V.Vimentin intermediate filament assembly regulates fibroblast invasion in fibrogenic lung injury. JCI Insight. 2019;4(7):e123253. https://doi.org/10.1172/jci.insight.123253.

Yuan T, Volckaert T, Hopkins S, Klinkhammer K, Yuan J, Thannickal VJ, De Langhe SP. FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury. Stem Cell Reports. 2019 Apr 16. pii: S2213-6711(19)30125-0. doi: 10.1016/j.stemcr.2019.04.003. [Epub ahead of print]

Sgalla G, Kulkarni T, Antin-Ozerkis D, Thannickal VJ, Richeldi L. Update in Pulmonary Fibrosis 2018. Am J Respir Crit Care Med. 2019 Apr 24. https://doi.org/10.1164/rccm.201903-0542UP

Bhatt SP, Patel SB, Anderson EM, Baugh D, Givens T, Schumann C, Sanders JG, Windham ST, Cutter GR, Dransfield MT. Video Telehealth Pulmonary Rehabilitation Intervention In COPD Reduces 30-day Readmissions.Am J Respir Crit Care Med. 2019 Apr 12. doi: 10.1164/rccm.201902-0314LE. [Epub ahead of print]

Yan Z, Yang W, Parkitny L, Gibson SA, Lee KS, Collins F, Deshane JS, Cheng W, Weinmann AS, Wei H, Qin H, Benveniste EN. Deficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production. JCI Insight. 2019 Apr 2;5. pii: 126520. doi: 10.1172/jci.insight.126520.

March 2019

Hough KP, Deshane JS. Exosomes in Allergic Airway Diseases. Curr Allergy Asthma Rep. 2019 Mar 22;19(5):26. doi: 10.1007/s11882-019-0857-3.

Iyer AS, Holm KE, Bhatt SP, Kim V, Kinney GL, Wamboldt FS, Jacobs MR, Regan EA, Armstrong HF, Lowe KE, Martinez CH, Dransfield MT, Foreman MG, Shinozaki G, Hanania NA, Wise RA, Make BJ, Hoth KF; COPDGene Investigators.Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - A cross sectional analysis of the COPDGene cohort. J Psychosom Res. 2019 Mar;118:18-26. doi: 10.1016/j.jpsychores.2019.01.002. Epub 2019 Jan 7.

February 2019

Vestbo J, Dransfield M, Anderson JA, Brook RD, Calverley PMA, Celli BR, Cowans NJ, Crim C, Martinez F, Newby DE, Yates J, Lange P. Impact of pre-enrolment medication use on clinical outcomes in SUMMIT. ERJ Open Res. 2019 Feb 25;5(1). pii: 00203-2018. doi: 10.1183/23120541.00203-2018. eCollection 2019 Feb.

Press VG, Au DH, Bourbeau J, Dransfield MT, Gershon AS, Krishnan JA, Mularski RA, Sciurba FC, Sullivan J, Feemster LC. Reducing Chronic Obstructive Pulmonary Disease Hospital Readmissions. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2019 Feb;16(2):161-170. doi: 10.1513/AnnalsATS.201811-755WS.

Ejike CO, Dransfield MT, Hansel NN, Putcha N, Raju S, Martinez CH, Han MK. Chronic Obstructive Pulmonary Disease in America's Black Population. Am J Respir Crit Care Med. 2019 Feb 21. doi: 10.1164/rccm.201810-1909PP. [Epub ahead of print]

Casey JD, Janz DR, Russell DW, Vonderhaar DJ, Joffe AM, Dischert KM, Brown RM, Zouk AN, Gulati S, Heideman BE, Lester MG, Toporek AH, Bentov I, Self WH, Rice TW, Semler MW; PreVent Investigators and the Pragmatic Critical Care Research Group.Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults. N Engl J Med. 2019 Feb 18. doi: 10.1056/NEJMoa1812405. [Epub ahead of print]

Wells AU, Brown KK, Flaherty KR, Kolb M, Thannickal VJ; IPF Consensus Working Group;Idiopathic interstitial pneumonia or idiopathic interstitial pneumonitis: what's in a name? Eur Respir J. 2019 Feb 14;53(2). pii: 1801939. doi: 10.1183/13993003.01939-2018. Print 2019 Feb.

Washko GR, Nardelli P, Ash SY, Vegas Sanchez-Ferrero G, Rahaghi FN, Come CE, Dransfield MT, Kalhan R, Han MK, Bhatt S, Wells JM, Aaron CP, Diaz AA, Ross JC, Cuttica MJ, Labaki WW, Querejeta Roca G, Shah AM, Young K, Kinney GL, Hokanson JE, Agusti A, San José Estépar R; COPDGene Investigators.Arterial Vascular Pruning, Right Ventricular Size and Clinical Outcomes in COPD. Am J Respir Crit Care Med. 2019 Feb 13. doi: 10.1164/rccm.201811-2063OC. [Epub ahead of print]

January 2019

Criner RN, Labaki WW, Regan EA, Bon JM, Soler X, Bhatt SP, Murray S, Hokanson JE, Silverman EK, Crapo JD, Curtis JL, Martinez FJ, Make BJ, Han MK, Martinez CH; COPDGene® Investigators. Mortality and Exacerbations by Global Initiative for Chronic Obstructive Lung Disease Groups ABCD: 2011 Versus 2017 in the COPDGene® Cohort. Chronic Obstr Pulm Dis. 2019 Jan 10;6(1):64-73. doi: 10.15326/jcopdf.6.1.2018.0130.

Bhatt, SP. It’s Time to Rehabilitate Pulmonary Rehabilitation. Annals of the American Thoracic Society. Vol. 16, No. 1 | Jan 01, 2019 https://doi.org/10.1513/AnnalsATS.201809-641ED PubMed: 30592449

Genschmer KR, Russell DW, Lal C, Szul T, Bratcher PE, Noerager BD, Roda MA, Xu X, Rezonzew G, Viera L, Dobosh BS, Margaroli C, Abdalla TH, King RW, McNicholas CM, Wells JM, Dransfield MT, Tirouvanziam R, Gaggar A, Blalock JE. Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung. Cell. Volume 176, ISSUE 1, P113-126.e15, 2019 Jan 10.

Kurundkar D, Kurundkar AR, Bone NB, Becker EJ, Jr., Liu W, Chacko B, Darley-Usmar V, Zmijewski JW, Thannickal VJ. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. JCI Insight. 2019 Jan 10.

2018 Publications

March 2019

Anand S.Iyer, Kristen E.Holm, Surya P.Bhatt, Victor Kim, Gregory L.Kinney, Frederick S.Wamboldt, Michael R.Jacobs, Elizabeth A.Regan, Hilary F.Armstrong, Katherine E.Lowe, Carlos H.Martinez, Mark T.Dransfield, Marilyn G.Foreman, Gen Shinozaki, Nicola A.Hanania, Robert A.Wise, Barry J.Make, Karin F.Hoth. Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - A cross sectional analysis of the COPDGene cohort. Journal of Psychosomatic Research Volume 118, Pages 18-26

February 2019

Jonathan D. Casey, M.D., David R. Janz, M.D., Derek W. Russell, M.D., Derek J. Vonderhaar, M.D., Aaron M. Joffe, D.O., Kevin M. Dischert, M.D., Ryan M. Brown, M.D., Aline N. Zouk, M.D., Swati Gulati, M.B., B.S., Brent E. Heideman, M.D., Michael G. Lester, M.D., Alexandra H. Toporek, M.D., Itay Bentov, M.D., Ph.D., Wesley H. Self, M.D., Todd W. Rice, M.D., and Matthew W. Semler, M.D. for the PreVent Investigators and the Pragmatic Critical Care Research Group. Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults. February 18, 2019. DOI: 10.1056/NEJMoa1812405. https://www.nejm.org/doi/full/10.1056/NEJMoa1812405?query=featured_home

January 2019

J Michael Wells, Douglas A Arenberg, Igor Barjaktarevic, Surya P Bhatt, Russell P Bowler, Stephanie A Christenson, David J Couper, Mark T Dransfield, MeiLan K Han, Eric A. Hoffman, Robert J Kaner, Victor Kim, Eric Kleerup, Fernando J. Martinez, Wendy C Moore, Sarah L O'Beirne, Robert Paine III, Nirupama Putcha; Sanjeev M Raman, R. Graham Barr, Stephen I Rennard, Prescott G Woodruff, and Jeffrey L Curtis. Safety and Tolerability of Comprehensive Research Bronchoscopy in COPD: Results from the SPIROMICS Bronchoscopy Sub-Study. https://doi.org/10.1513/AnnalsATS.201807-441OC. PubMed: 30653926. Received: July 01, 2018. Accepted: January 16, 2019. Published Online: January 17, 2019.

Bhatt, SP. It’s Time to Rehabilitate Pulmonary Rehabilitation. Annals of the American Thoracic Society. Vol. 16, No. 1 | Jan 01, 2019 https://doi.org/10.1513/AnnalsATS.201809-641ED PubMed: 30592449

Genschmer KR, Russell DW, Lal C, Szul T, Bratcher PE, Noerager BD, Roda MA, Xu X, Rezonzew G, Viera L, Dobosh BS, Margaroli C, Abdalla TH, King RW, McNicholas CM, Wells JM, Dransfield MT, Tirouvanziam R, Gaggar A, Blalock JE. Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung. Cell. Volume 176, ISSUE 1, P113-126.e15, 2019 Jan 10.

Kurundkar D, Kurundkar AR, Bone NB, Becker EJ, Jr., Liu W, Chacko B, Darley-Usmar V, Zmijewski JW, Thannickal VJ. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. JCI Insight. 2019 Jan 10.

November 2018

J. Michael Wells, Margaret M. Parker, Robert A. Oster, Russ P. Bowler, Mark T. Dransfield, Surya P. Bhatt, Michael H. Cho, Victor Kim, Jeffrey L. Curtis, Fernando J. Martinez, Robert Paine III, Wanda O’Neal, Wassim W. Labaki, Robert J. Kaner, Igor Barjaktarevic, MeiLan K. Han, Edwin K. Silverman, James D. Crapo, R. Graham Barr, Prescott Woodruff, Peter J. Castaldi, Amit Gaggar, and the SPIROMICS and COPDGene Investigators. Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene. JCI Insight.

October 2018

Davies JC, Moskowitz SM, Brown C, Horsley A, Mall MA, McKone EF, Plant BJ, Prais D, Ramsey BW, Taylor-Cousar JL, Tullis E, Uluer A, McKee CM, Robertson S, Shilling RA, Simard C, Van Goor F, Waltz D, Xuan F, Young T, Rowe SM; VX16-659-101 Study Group. VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles.

September 2018

Sandeep Bodduluri, Abhilash S. Kizhakke Puliyakote, Sarah E. Gerard, Joseph M. Reinhardt, Eric A. Hoffman, John D. Newell Jr., Hrudaya P. Nath, MeiLan K. Han, George R. Washko, Raúl San José Estépar, Mark T. Dransfield, Surya P. Bhatt, and COPDGene Investigators. Airway fractal dimension predicts respiratory morbidity and mortality in COPD. The Journal of Clinical Investigation. September 26, 2018.

Matthew AR, Bhatt SP, Colangelo LA, Allen NB, Jacobs DR Jr, Auer R, Dransfield MT, Hitsman B, Washko GR, Kalhan R.Life-course Smoking Trajectories and Risk of Emphysema in Middle Age: The CARDIA Lung Study. Am J Respir Crit Care Med. 2018 Sep 14. doi: 10.1164/rccm.201808-1568LE. [Epub ahead of print]

Bodduluri S, Kizhakke Puliyakote AS, Gerard SE, Reinhardt JM, Hoffman EA, Newell JD Jr, Nath HP, Han MK, Washko GR, San José Estépar R, Dransfield MT, Bhatt SP. Airway Fractal Dimension Predicts Respiratory Morbidity and Mortality in COPD.J Clin Invest. 2018 Sep 17. pii: 120693. doi: 10.1172/JCI120693. [Epub ahead of print]

July 2018

Gulati S, Zouk AN, Kalehoff JP, Wren CS, Davison PN, Kirkpatrick DP, Bhatt SP, Dransfield MT, Wells JM. The use of a standardized order set reduces systemic corticosteroid dose and length of stay for individuals hospitalized with acute exacerbations of COPD: a cohort study. 27 July 2018 Volume 2018:13 Pages 2271—2278

Hough KP, Wilson LS, Trevor JL, Strenkowski JG, Maina N, Kim YI, Spell ML, Wang Y, Chanda D, Dager JR, Sharma NS, Curtiss M, Antony VB, Dransfield MT, Chaplin DD, Steele C, Barnes S, Duncan SR, Prasain JK, Thannickal VJ, Deshane JS.Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics. Sci Rep. 2018 Jul 9;8(1):10340. doi: 10.1038/s41598-018-28655-9.

June 2018

Hough KP, Trevor JL, Strenkowski JG, Wang Y, Chacko BK, Tousif S, Chanda D, Steele C, Antony VB, Dokland T, Ouyang X, Zhang J, Duncan SR, Thannickal VJ, Darley-Usmar VM, Deshane JS.Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells. Redox Biol. 2018 Jun 25;18:54-64. doi: 10.1016/j.redox.2018.06.009. [Epub ahead of print]

Bhatt SP, Kazerooni EA, Newell JD Jr, Hokanson JE, Budoff MJ, Dass CA, Martinez CH, Bodduluri S, Jacobson FL, Yen A, Dransfield MT, Fuhrman C, Nath H; COPDGene Investigators. Visual estimate of coronary artery calcium predicts cardiovascular disease in COPD. Chest. 2018 Jun 8. pii: S0012-3692(18)30888-2. doi: 10.1016/j.chest.2018.05.037. [Epub ahead of print]

Larson-Casey JL, Gu L, Jackson PL, Briles DE, Hale JY, Blalock JE, Wells JM, Deshane JS, Wang Y, Davis D, Antony VB, Massicano AVF, Lapi SE, Carter AB. Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke-induced Pneumonia. Am J Respir Crit Care Med. 2018 Jun 13. doi: 10.1164/rccm.201712-2388OC. [Epub ahead of print]

Iyer AS, Benzo RP, Bakitas MA. Easing the Tension Between Palliative Care and Intensive Care in Chronic Obstructive Pulmonary Disease. J Palliat Care. 2018 Jul;33(3):123-124. doi: 10.1177/0825859718782505.

Ash SY, Harmouche R, Ross JC, Diaz AA, Rahaghi FN, Sanchez-Ferrero GV, Putman RK, Hunninghake GM, Onieva JO, Martinez FJ, Choi AM, Bowler RP, Lynch DA, Hatabu H, Bhatt SP, Dransfield MT, Wells JM, Rosas IO, San Jose Estepar R, Washko GR; COPDGene Investigators. Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort. Radiology. 2018 Jun 5:172688. doi: 10.1148/radiol.2018172688. [Epub ahead of print]

May 2018

Criner GJ, Sue R, Wright S, Dransfield M, Rivas-Perez H, Wiese T, Sciurba FC, Shah PL, Wahidi MM, de Oliveira HG, Morrissey B, Cardoso PFG, Hays S, Majid A, Pastis N Jr, Kopas L, Vollenweider M, McFadden PM, Machuzak M, Hsia DW, Sung A, Jarad N, Kornaszewska M, Hazelrigg S, Krishna G, Armstrong B, Shargill NS, Slebos DJ; LIBERATE Study Group. A Multicenter RCT of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE). Am J Respir Crit Care Med. 2018 May 22. doi: 10.1164/rccm.201803-0590OC. [Epub ahead of print]

Wells AU, Brown KK, Flaherty KR, Kolb M, Thannickal VJ; IPF Consensus Working Group. What's in a name? That which we call IPF, by any other name would act the same. Eur Respir J. 2018 May 17;51(5). pii: 1800692. doi: 10.1183/13993003.00692-2018. Print 2018 May.

Shi R, Cao Z, Li H, Graw J, Zhang G, Thannickal VJ, Cheng G.Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria. PLoS Pathog. 2018 May 18;14(5):e1007026. doi: 10.1371/journal.ppat.1007026. [Epub ahead of print]

Huilgol P, Bhatt SP, Biligowda N, Wright NC, Wells JM. Association of e-cigarette use with oral health: a population-based cross-sectional questionnaire study. J Public Health (Oxf). 2018 May 18. doi: 10.1093/pubmed/fdy082. [Epub ahead of print]

Dodi AE, Ajayi IO, Chang C, Beard M, Ashley SL, Huang SK, Thannickal VJ, Tschumperlin DJ, Sisson TH, Horowitz JC. Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli. Respir Res. 2018 May 10;19(1):91. doi: 10.1186/s12931-018-0801-4.

Wang Y, Schafer CC, Hough KP, Tousif S, Duncan SR, Kearney JF, Ponnazhagan S, Hsu HC, Deshane JS. Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5. J Immunol. 2018 May 11. pii: ji1701069. doi: 10.4049/jimmunol.1701069. [Epub ahead of print]

Krick S, Grabner A, Baumlin N, Yanucil C, Helton S, Grosche A, Sailland J, Geraghty P, Viera L, Russell DW, Wells JM, Xu X, Gaggar A, Barnes J, King GD, Campos M, Faul C, Salathe M. Fibroblast Growth Factor 23 and Klotho Contribute to Airway Inflammation. Eur Respir J. 2018 May 10. pii: 1800236. doi: 10.1183/13993003.00236-2018. [Epub ahead of print]

April 2018

Guimbellot J, Solomon GM, Baines A, Heltshe SL, VanDalfsen J, Joseloff E, Sagel SD, Rowe SM, GOALe(2) Investigators.Effectiveness of ivacaftor in cystic fibrosis patients with non-G551D gating mutations.J Cyst Fibros. 2018 Apr 20. pii: S1569-1993(18)30090-0. doi: 10.1016/j.jcf.2018.04.004. [Epub ahead of print]

Cui H, Banerjee S, Guo S, Xie N, Liu G. IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages. J Immunol. 2018 May 1;200(9):3218-3230. doi: 10.4049/jimmunol.1701571. Epub 2018 Mar 21.

Zhou Z, Qu J, He L, Peng H, Chen P, Zhou Y. α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction. Stem Cell Res Ther. 2018 May 2;9(1):122. doi: 10.1186/s13287-018-0868-3.

Zhou Y. Most Good, Least Harm: Isoform-Specific Targeting of ROCK in Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 Apr;58(4):421-422. doi: 10.1165/rcmb.2017-0426ED.

Bernard K. Collagen Biosynthesis in Pulmonary Fibrosis: Unraveling the Metabolic Web. Am J Respir Cell Mol Biol. 2018 May;58(5):545-546. doi: 10.1165/rcmb.2017-0350ED.

Thannickal VJ, Antony VB. Is personalized medicine a realistic goal in idiopathic pulmonary fibrosis? Expert Rev Respir Med. 2018 Apr 19:1-3. doi: 10.1080/17476348.2018.1464913. [Epub ahead of print]

Lipson DA, Barnhart F, Brealey N, Brooks J, Criner GJ, Day NC, Dransfield MT, Halpin DMG, Han MK, Jones CE, Kilbride S, Lange P, Lomas DA, Martinez FJ, Singh D, Tabberer M, Wise RA, Pascoe SJ; IMPACT Investigators.Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD. N Engl J Med. 2018 Apr 18. doi: 10.1056/NEJMoa1713901. [Epub ahead of print]

Bhatt SP. Am J Respir Crit Care Med. 2018 Apr 13. doi: 10.1164/rccm.201802-0257LE. [Epub ahead of print]Early COPD Or Early Detection of Mild Disease?

Putcha N, Paul GG, Azar A, Wise RA, O'Neal WK, Dransfield MT, Woodruff PG, Curtis JL, Comellas AP, Drummond MB, Lambert AA, Paulin LM, Fawzy A, Kanner RE, Paine R 3rd, Han MK, Martinez FJ, Bowler RP, Barr RG, Hansel NN; SPIROMICS investigators. PLoS One. 2018 Apr 12;13(4):e0194924. doi: 10.1371/journal.pone.0194924. eCollection 2018. Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS.

Reyfman PA, Washko GR, Dransfield MT, Spira A, Han MK, Kalhan R. Am J Respir Crit Care Med. 2018 Apr 6. doi: 10.1164/rccm.201801-0120PP. [Epub ahead of print] Defining Impaired Respiratory Health: A Paradigm Shift for Pulmonary Medicine.

March 2018

Peabody JE, Shei RJ, Bermingham BM, Phillips SE, Turner B, Rowe SM, Solomon GM. Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1. doi: 10.1152/ajplung.00556.2017. [Epub ahead of print] Seeing Cilia: Imaging Modalities for Ciliary Motion and Clinical Connections.

February 2018

Guimbellot JS, Acosta EP, Rowe SM. Sensitivity of ivacaftor to drug-drug interactions with rifampin, a cytochrome P450 3A4 inducer. Pediatr Pulmonol. 2018 Feb 28. doi: 10.1002/ppul.23971. [Epub ahead of print]

Payne GA, Wells JM.Deciphering COPD and associated cardiovascular impairment. Lancet Respir Med. 2018 Feb 21. pii: S2213-2600(18)30047-X. doi: 10.1016/S2213-2600(18)30047-X. [Epub ahead of print]

Garcia BA, Carden JL, Goodwin DL, Smith TA, Gaggar A, Leon K, Antony VB, Rowe SM, Solomon GM. Implementation of a successful eradication protocol for Burkholderia Cepacia complex in cystic fibrosis patients. BMC Pulm Med. 2018 Feb 14;18(1):35. doi: 10.1186/s12890-018-0594-8.

Kunisaki KM, Dransfield MT, Anderson JA, Brook RD, Calverley PMA, Celli BR, Crim C, Hartley BF, Martinez FJ, Newby DE, Pragman AA, Vestbo J, Yates JC, Niewoehner DE; SUMMIT Investigators. Exacerbations of Chronic Obstructive Pulmonary Disease and Cardiac Events: A Cohort Analysis.Am J Respir Crit Care Med. 2018 Feb 14. doi: 10.1164/rccm.201711-2239OC. [Epub ahead of print]

Dransfield MT, McAllister DA, Anderson JA, Brook RD, Calverley PMA, Celli BR, Crim C, Gallot N, Martinez FJ, Scanlon PD, Yates J, Vestbo J, Newby DE; SUMMIT Investigators.Beta-blocker Therapy and Clinical Outcomes in Patients with Moderate COPD and Heightened Cardiovascular Risk: An Observational Sub-study of SUMMIT. Ann Am Thorac Soc. 2018 Feb 6. doi: 10.1513/AnnalsATS.201708-626OC. [Epub ahead of print]

Iyer, AS, Dransfield, MT. The "Obesity Paradox" in Chronic Obstructive Pulmonary Disease: Can It Be Resolved? Ann Am Thorac Soc. 2018 Feb;15(2):158-159. doi: 10.1513/AnnalsATS.201711-901ED.

Bhatt, SP. Diagnosis of Chronic Obstructive Pulmonary Disease: Breathing New Life Into an Old Debate. Ann Am Thorac Soc. 2018 Feb;15(2):163-165. doi: 10.1513/AnnalsATS.201709-733ED.

Askari K, Sneij W, Krick S, Alvarez RA. Reply: We Did This, and the Patient Improved: True, True, and Unrelated? Ann Am Thorac Soc. 2018 Feb;15(2):269. doi: 10.1513/AnnalsATS.201711-865LE.

January 2018

Kalhan R, Dransfield MT, Colangelo LA, Cuttica MJ, Jacobs DR Jr, Thyagarajan B, San Jose Estepar R, Harmouche R, Onieva Onieva J, Ash SY, Okajima Y, Iribarren C, Sidney S, Lewis CE, Mannino DM, Liu K, Smith LJ, Washko GR.Respiratory Symptoms in Young Adults and Future Lung Disease: The CARDIA Lung Study. Am J Respir Crit Care Med. 2018 Jan 25. doi: 10.1164/rccm.201710-2108OC. [Epub ahead of print]

Bhatt SP, Anderson JA, Brook RD, Calverley PMA, Celli BR, Cowans NJ, Crim C, Martinez FJ, Newby DE, Vestbo J, Yates JC, Dransfield MT. Cigarette smoking and response to inhaled corticosteroids in COPD. Eur Respir J. 2018 Jan 18;51(1). pii: 1701393. doi: 10.1183/13993003.01393-2017. Print 2018 Jan.

Bhatt SP, Kim YI, Harrington KF, Hokanson JE, Lutz SM, Cho MH, DeMeo DL, Wells JM, Make BJ, Rennard SI, Washko GR, Foreman MG, Tashkin DP, Wise RA, Dransfield MT, Bailey WC; COPDGene Investigators.Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years. Thorax. 2018 Jan 11. pii: thoraxjnl-2017-210722. doi: 10.1136/thoraxjnl-2017-210722. [Epub ahead of print]

Birket SE, Davis JM, Fernandez CM, Tuggle KL, Oden AM, Chu KK, Tearney GJ, Fanucchi MV, Sorscher EJ, Rowe SM.Development of an airway mucus defect in the cystic fibrosis rat. JCI Insight. 2018 Jan 11;3(1). pii: 97199. doi: 10.1172/jci.insight.97199. [Epub ahead of print]

Copeland CR, Nath H, Terry NLJ, Wilson CG, Kim YI, Lynch DA, Bodduluri S, Wells JM, Dransfield MT, Díaz AA, Washko GR, Foreman MG, Bhatt SP; Genetic Epidemiology of COPD (COPDGene) Investigators. Paratracheal Paraseptal Emphysema and Expiratory Central Airway Collapse in Smokers.Ann Am Thorac Soc. 2018 Jan 3. doi: 10.1513/AnnalsATS.201709-713OC. [Epub ahead of print]

2017 Publications

December 2017

Raju SV, Rowe SM. Not Simply the Lesser of Two Evils. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 20. doi: 10.1152/ajplung.00534.2017. [Epub ahead of print]

Martirossian A, Shah S, Carrete L, Valle J, Valentine V. Durability of Sirolimus for Lymphangioleiomyomatosis. Am J Med Sci. 2017 Dec;354(6):603-607. doi: 10.1016/j.amjms.2016.11.028. Epub 2016 Dec 5.

Parekh, TM, Bhatt, SP, Westfall, AO, Wells JM, Kirkpatrick, DN, Iyer, AS, Mugavero M, Willig, JH, Dransfield, MT; Implications of DRG Classification in a Bundled Payment Initiative for COPD, The American Journal of Accountable Care, December 2017

Heltshe SL, Rowe SM, Skalland M, Baines A, Jain M; GOAL Investigators of the Cystic Fibrosis Foundation Therapeutics Development Network.Ivacaftor-treated CF Patients Derive Long-term Benefit Despite No Short-term Clinical Improvement. Am J Respir Crit Care Med. 2017 Dec 19. doi: 10.1164/rccm.201710-2046LE. [Epub ahead of print]

McNeil JB, Shaver CM, Kerchberger VE, Russell DW, Grove BS, Warren MA, Wickersham NE, Ware LB, McDonald WH, Bastarache JA. Novel Method for Non-Invasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 Dec 18. doi: 10.1164/rccm.201707-1474OC. [Epub ahead of print]

McDonald MN, Diaz AA, Rutten E, Lutz SM, Harmouche R, San Jose Estepar R, Kinney G, Hokanson JE, Gower BA, Wouters EFM, Rennard SI1, Hersh CP, Casaburi R, Dransfield MT, Silverman EK, Washko GR. Chest Computed Tomography-Derived Low Fat-Free Mass Index and Mortality in COPD. Eur Respir J. 2017 Dec 14;50(6). pii: 1701134. doi: 10.1183/13993003.01134-2017. Print 2017 Dec.

Bernard K, Logsdon NJ, Benavides GA, Sanders Y, Zhang J, Darley-Usmar VM, Thannickal VJ. Glutaminolysis is required for TGF-β1-induced myofibroblast differentiation and activation. J Biol Chem. 2017 Dec 8. pii: jbc.RA117.000444. doi: 10.1074/jbc.RA117.000444. [Epub ahead of print]

Lutful Kabir F, Ambalavanan N, Liu G, Li P, Solomon GM, Lal CV, Mazur M, Halloran B, Szul T, Gerthoffer WT, Rowe SM, Harris WT.microRNA-145 Antagonism Reverses TGF-β Inhibition of F508del CFTR Correction in Airway Epithelia. Am J Respir Crit Care Med. 2017 Dec 12. doi: 10.1164/rccm.201704-0732OC. [Epub ahead of print]

Semler MW, Janz DR, Casey JD, Russell DW, Rice TW. Response. Chest. 2017 Dec;152(6):1351. doi: 10.1016/j.chest.2017.09.032.

Lancaster LH, de Andrade JA, Zibrak JD, Padilla ML, Albera C, Nathan SD, Wijsenbeek MS, Stauffer JL, Kirchgaessler KU, Costabel U. Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosis. Eur Respir Rev. 2017 Dec 6;26(146). pii: 170057. doi: 10.1183/16000617.0057-2017. Print 2017 Dec 31.

Cho DY, Hoffman KJ, Gill GS, Lim DJ, Skinner D, Mackey C, Rowe SM, Woodworth BA.Protective and antifungal properties of Nanodisk-Amphotericin B over commercially available Amphotericin B. World J Otorhinolaryngol Head Neck Surg. 2017 Mar 7;3(1):2-8. doi: 10.1016/j.wjorl.2017.01.002. eCollection 2017 Mar.

Butts B, Goeddel LA, George DJ, Steele C, Davies JE, Wei CC, Varagic J, George JF, Ferrario CM, Melby SJ, Dell'Italia LJ.Increased Inflammation in Pericardial Fluid Persists 48 Hours After Cardiac Surgery. Circulation. 2017 Dec 5;136(23):2284-2286. doi: 10.1161/CIRCULATIONAHA.117.029589.

Liu G, Thannickal VJ. The Lung Likes the Little Fella miR-29. Am J Respir Cell Mol Biol. 2017 Dec;57(6):637-638. doi: 10.1165/rcmb.2017-0266ED.

November 2017

Stalvey MS, Havasi V, Tuggle KL, Wang D, Birket S, Rowe SM, Sorscher EJ. Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat. PLoS One. 2017 Nov 30;12(11):e0188497. doi: 10.1371/journal.pone.0188497. eCollection 2017.

Rangarajan S, Bernard K, Thannickal VJ. Mitochondrial Dysfunction in Pulmonary Fibrosis. Ann Am Thorac Soc. 2017 Nov;14(Supplement_5):S383-S388. doi: 10.1513/AnnalsATS.201705-370AW.

Solomon GM, Fu L, Rowe SM, Collawn JF. The therapeutic potential of CFTR modulators for COPD and other airway diseases. Curr Opin Pharmacol. 2017 Nov 10;34:132-139. doi: 10.1016/j.coph.2017.09.013. [Epub ahead of print]

Rowe SM, Daines C, Ringshausen FC, Kerem E, Wilson J, Tullis E, Nair N, Simard C, Han L, Ingenito EP, McKee C, Lekstrom-Himes J, Davies JC.Tezacaftor-Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis. N Engl J Med. 2017 Nov 3. doi: 10.1056/NEJMoa1709847. [Epub ahead of print]

October 2017

Krick S, Baumlin N, Aller SP, Aguiar C, Grabner A, Sailland J, Mendes E, Schmid A, Qi L, David NV, Geraghty P, King G, Birket SE, Rowe SM, Faul C, Salathe M.Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia. Sci Rep. 2017 Oct 30;7(1):14388. doi: 10.1038/s41598-017-14811-0.

Kaza N, Raju SV, Cadillac JM, Trombley JA, Rasmussen L, Tang L, Dohm E, Harrod KS, Rowe SM.Use of ferrets for electrophysiologic monitoring of ion transport. PLoS One. 2017 Oct 27;12(10):e0186984. doi: 10.1371/journal.pone.0186984. eCollection 2017.

Reed RM, Cabral H, Dransfield M, Eberlein M, Merlo C, Mulligan MJ, Netzer G, Sanchez PG, Scharf SM, Sin DD, Celli BR.Survival of Lung Transplant Candidates with COPD: BODE Reconsidered. Chest. 2017 Oct 17. pii: S0012-3692(17)32900-8. doi: 10.1016/j.chest.2017.10.008. [Epub ahead of print]

Abston E, Comellas A, Reed RM, Kim V, Wise RA, Brower R, Fortis S, Beichel R, Bhatt S, Zabner J, Newell J, Hoffman EA, Eberlein M. Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25-75/FVC) in COPD. BMJ Open Respir Res. 2017 Oct 13;4(1):e000231. doi: 10.1136/bmjresp-2017-000231. eCollection 2017.

Oates GR, Hamby BW, Stepanikova I, Knight SJ, Bhatt SP, Hitchcock J, Schumann C, Dransfield MT.Social Determinants of Adherence to Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease. COPD. 2017 Oct 11:1-8. doi: 10.1080/15412555.2017.1379070. [Epub ahead of print]

Volckaert T, Yuan T, Chao CM, Bell H, Sitaula A, Szimmtenings L, El Agha E, Chanda D, Majka S, Bellusci S, Thannickal VJ, Fässler R, De Langhe SP. Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells. Dev Cell. 2017 Oct 9;43(1):48-59.e5. doi: 10.1016/j.devcel.2017.09.003.

McDonald ML. Multiomics Approach to Asthma: Navigating the Network. Am J Respir Cell Mol Biol. 2017 Oct;57(4):381-382. doi: 10.1165/rcmb.2017-0220ED.

September 2017

Raju SV, Rasmussen L, Sloane PA, Tang LP, Libby EF, Rowe SM. Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice. Respir Res. 2017 Sep 18;18(1):173. doi: 10.1186/s12931-017-0656-0.

Guimbellot J, Sharma J, Rowe SM.Toward inclusive therapy with CFTR modulators: Progress and challenges. Pediatr Pulmonol. 2017 Sep 7. doi: 10.1002/ppul.23773. [Epub ahead of print]

Askari K, Sneij W, Krick S, Alvarez RA.Going with the Flow: Saddle Pulmonary Embolism Complicated by Severe Hypoxemia without Shock. Ann Am Thorac Soc. 2017 Sep;14(9):1479-1484. doi: 10.1513/AnnalsATS.201702-145CC

Tipirneni KE, Grayson JW, Zhang S, Cho DY, Skinner DF, Lim DJ, Mackey C, Tearney GJ, Rowe SM, Woodworth BA.Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography. Int Forum Allergy Rhinol. 2017 Sep;7(9):920-925. doi: 10.1002/alr.21975.

Sailland J, Grosche A, Baumlin N, Dennis JS, Schmid A, Krick S, Salathe M. Role of Smad3 and p38 Signaling in Cigarette Smoke-induced CFTR and BK dysfunction in Primary Human Bronchial Airway Epithelial Cells. Sci Rep. 2017 Sep 5;7(1):10506. doi: 10.1038/s41598-017-11038-x.

August 2017

Shenoy AT, Brissac T, Gilley RP, Kumar N, Wang Y, Gonzalez-Juarbe N, Hinkle WS, Daugherty SC, Shetty AC, Ott S, Tallon LJ, Deshane J, Tettelin H, Orihuela CJ. Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing. PLoS Pathog. 2017 Aug 25;13(8):e1006582. doi: 10.1371/journal.ppat.1006582. eCollection 2017 Aug

Bodduluri S, Reinhardt JM, Hoffman EA, Newell JD Jr, Bhatt SP. Recent Advances in CT Imaging in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2017 Aug 16. doi: 10.1513/AnnalsATS.201705-377FR. [Epub ahead of print]

Garth JM, Reeder KM, Godwin MS, Mackel JJ, Dunaway CW, Blackburn JP, Steele C. IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection. J Immunol. 2017 Aug 7. pii: ji1602186. doi: 10.4049/jimmunol.1602186. [Epub ahead of print]

Li FJ, Surolia R, Li H, Wang Z, Kulkarni T, Liu G, de Andrade JA, Kass DJ, Thannickal VJ, Duncan SR, Antony VB. Autoimmunity to Vimentin Is Associated with Outcomes of Patients with Idiopathic Pulmonary Fibrosis. J Immunol. 2017 Jul 28. pii: ji1700473. doi: 10.4049/jimmunol.1700473. [Epub ahead of print]

Sharma NS, Wille KM, Athira S, Zhi D, Hough KP, Diaz-Guzman E, Zhang K, Kumar R, Rangarajan S, Eipers P, Wang Y, Srivastava RK, Rodriguez Dager JV, Athar M, Morrow C, Hoopes CW, Chaplin DD, Thannickal VJ, Deshane JS. Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipients. J Heart Lung Transplant. 2017 Jul 15. pii: S1053-2498(17)31898-3. doi: 10.1016/j.healun.2017.07.007. [Epub ahead of print]

Luckhardt T, Thannickal VJ. Measures of Frailty in Chronic Lung Diseases. Ann Am Thorac Soc. 2017 Aug;14(8):1266-1267. doi: 10.1513/AnnalsATS.201706-420ED.

July 2017

Jiang C, Liu G, Luckhardt T, Antony V, Zhou Y, Carter AB, Thannickal VJ, Liu RM. Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease. Aging Cell. 2017 Jul 19. doi: 10.1111/acel.12643. [Epub ahead of print]

Bodduluri S, Reinhardt JM, Hoffman EA, Newell JD Jr, Nath H, Dransfield MT, Bhatt SP; COPDGene Investigators. Signs of Gas Trapping in Normal Lung Density Regions in Smokers. Am J Respir Crit Care Med. 2017 Jul 14. doi: 10.1164/rccm.201705-0855OC. [Epub ahead of print]

June 2017

Zouk AN, Wells JM. In Rotterdam, size really does matter: implications of pulmonary artery enlargement on mortality. Eur Respir J. 2017 Jun 15;49(6). pii: 1700750. doi: 10.1183/13993003.00750-2017. Print 2017 Jun. No abstract available. PMID: 28619963

Khauli S, Abston E, Sajjad H, Bolukbas S, Lopez JMA, Saad R Jr, Bhatt SP, Eberlein M.Incomplete fissures are associated with increased alveolar ventilation via spiracles in severe emphysema. Interact Cardiovasc Thorac Surg. 2017 Jul 6. doi: 10.1093/icvts/ivx220. [Epub ahead of print]

May 2017

Barnes JW, Dweik RA. Pulmonary Hypertension and Precision Medicine through the "Omics" Looking Glass. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1558-1560. doi: 10.1164/rccm.201704-0750ED.

Grabner A, Mazzaferro S, Cianciolo G, Krick S, Capelli I, Rotondi S, Ronco C, La Manna G, Faul C. Fibroblast Growth Factor 23: Mineral Metabolism and Beyond. Contrib Nephrol. 2017;190:83-95. doi: 10.1159/000468952. Epub 2017 May 23.

Cuttica MJ, Bhatt SP, Rosenberg SR, Beussink L, Shah SJ, Smith LJ, Dransfield MT, Kalhan R.Pulmonary artery to aorta ratio is associated with cardiac structure and functional changes in mild-to-moderate COPD. Int J Chron Obstruct Pulmon Dis. 2017 May 12;12:1439-1446. doi: 10.2147/COPD.S131413. eCollection 2017.

Berry RB, Brooks R, Gamaldo C, Harding SM, Lloyd RM, Quan SF, Troester MT, Vaughn BV. AASM Scoring Manual Updates for 2017 (Version 2.4). http://www.aasmnet.org/jcsm/ViewAbstract.aspx?pid=31007 J Clin Sleep Med. 2017 May 15;13(5):665-666. doi: 10.5664/jcsm.6576.

Budinger GS, Kohanski RA, Gan W, Kobor MS, Amaral LA, Armanios M, Kelsey K7, Pardo A, Tuder R, Macian F, Chandel N, Vaughan D, Rojas M, Mora AL, Kovacs E, Duncan SR, Finkel T, Choi A, Eickelberg O, Chen D, Agusti A, Selman M, Balch WE, Busse P, Lin A, Morimoto R, Sznajder JI, Thannickal VJ.The Intersection Of Aging Biology and The Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop. J Gerontol A Biol Sci Med Sci. 2017 May 12. doi: 10.1093/gerona/glx090. [Epub ahead of print]

Zhang X, Hu M, Lyu X, Li C, Thannickal VJ, Sanders YY. DNA Methylation Regulated Gene Expression in Organ Fibrosis. Biochim Biophys Acta. 2017 May 10. pii: S0925-4439(17)30147-3. doi: 10.1016/j.bbadis.2017.05.010. [Epub ahead of print]

Bhatt SP, Bodduluri S, Hoffman EA, Newell JD Jr, Sieren JC, Dransfield MT, Reinhardt JM. CT Measure of Lung At-risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 May 8. doi: 10.1164/rccm.201701-0050OC. [Epub ahead of print]

Semler MW, Janz DR, Russell DW, Casey JD, Lentz RJ, Zouk AN, deBoisblanc BP, Santanilla JI, Khan YA, Joffe AM, Stigler WS, Rice TW; Check-UP Investigators; Pragmatic Critical Care Research Group. A Multicenter, Randomized Trial of Ramped Position versus Sniffing Position during Endotracheal Intubation of Critically Ill Adults. Chest. 2017 May 6. pii: S0012-3692(17)30881-4. doi: 10.1016/j.chest.2017.03.061. [Epub ahead of print]

Chupp GL, Bradford ES, Albers FC, Bratton DJ, Wang-Jairaj J, Nelsen LM, Trevor JL, Magnan A, Ten Brinke A. Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomized, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial.Lancet Respir Med. 2017 May;5(5):390-400. doi: 10.1016/S2213-2600(17)30125-X. Epub 2017 Apr 5.

Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES; ATS Assembly on Respiratory Cell and Molecular Biology. An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 May;56(5):667-679. doi: 10.1165/rcmb.2017-0096ST.

April 2017

Solomon GM, Liu B, Sermet-Gaudelus I, Fajac I, Wilschanski M, Vermeulen F, Rowe SM.A multiple reader scoring system for Nasal Potential Difference parameters. J Cyst Fibros. 2017 Apr 29. pii: S1569-1993(17)30141-8. doi: 10.1016/j.jcf.2017.04.011. [Epub ahead of print]

Li FJ, Surolia R, Li H, Wang Z, Liu G, Liu RM, Mirov SB, Athar M, Thannickal VJ, Antony VB. Low Dose Cadmium Exposure Induces Peribronchiolar Fibrosis through Site Specific Phosphorylation of Vimentin.Am J Physiol Lung Cell Mol Physiol. 2017 Apr 27:ajplung.00087.2017. doi: 10.1152/ajplung.00087.2017. [Epub ahead of print]

Bhatt SP, Vegas-Sánchez-Ferrero G, Rahaghi FN, MacLean ES, Gonzalez-Serrano G, Come CE, Kinney GL, Hokanson JE, Budoff MJ, Cuttica MJ, Wells JM, San José Estépar R, Washko GR. Cardiac Morphometry on Computed Tomography and Exacerbation Reduction with β-blocker Therapy in COPD.Am J Respir Crit Care Med. 2017 Apr 25. doi: 10.1164/rccm.201702-0399LE. [Epub ahead of print]

King CS, Valentine V, Cattamanchi A, Franco-Palacios D, Shlobin OA, Brown AW, Singh R, Bogar L, Nathan SD. Early postoperative management after lung transplantation: Results of an international survey. Clin Transplant. 2017 Apr 20. doi: 10.1111/ctr.12985. [Epub ahead of print]

Gallardo Estrella L, Pompe E, Kuhnigk JM, Lynch DA, Bhatt SP, van Ginneken B, van Rikxoort EM. Computed tomography quantification of tracheal abnormalities in COPD and their influence on airflow limitation. Med Phys. 2017 Apr 17. doi: 10.1002/mp.12274. [Epub ahead of print]

Chupp GL, Bradford ES, Albers FC, Bratton DJ, Wang-Jairaj J, Nelsen LM, Trevor JL, Magnan A, Ten Brinke A. Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomized, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial. Lancet Respir Med. 2017 Apr 5. pii: S2213-2600(17)30125-X. doi: 10.1016/S2213-2600(17)30125-X. [Epub ahead of print]

March 2017

Reed RM, Dransfield MT, Eberlein M, Miller M, Netzer G, Pavlovich M, Pollin TI, Scharf SM, Shuldiner AR, Sin D, Mitchell BD. Gender differences in first and secondhand smoke exposure, spirometric lung function and cardiometabolic health in the old order Amish: A novel population without female smoking. PLoS One. 2017 Mar 31;12(3):e0174354. doi: 10.1371/journal.pone.0174354. eCollection 2017.

Ding Q, Subramanian I, Luckhardt TR, Che P, Waghray M, Zhao X, Bone N, Kurundkar AR4, Hecker L5, Hu M, Zhou Y, Horowitz JC, Vittal R, Thannickal VJ. Focal Adhesion Kinase Signaling Determines the Fate of Lung Epithelial Cells in Response to TGF-β. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 30:ajplung.00121.2016. doi: 10.1152/ajplung.00121.2016. [Epub ahead of print]

Gu L, Larson-Casey JL, Carter AB. Macrophages utilize the mitochondrial calcium uniporter for profibrotic polarization. FASEB J. 2017 Mar 28. pii: fj.201601371R. doi: 10.1096/fj.201601371R. [Epub ahead of print]

Longhurst H, Cicardi M, Craig T, Bork K, Grattan C, Baker J, Li HH, Reshef A, Bonner J, Bernstein JA, Anderson J, Lumry WR, Farkas H, Katelaris CH, Sussman GL, Jacobs J, Riedl M, Manning ME, Hebert J, Keith PK, Kivity S, Neri S, Levy DS, Baeza ML, Nathan R, Schwartz LB, Caballero T, Yang W, Crisan I, Hernandez MD, Hussain I, Tarzi M, Ritchie B, Králíčková P, Guilarte M, Rehman SM, Banerji A, Gower RG, Bensen-Kennedy D, Edelman J, Feuersenger H, Lawo JP, Machnig T, Pawaskar D, Pragst I, Zuraw BL; COMPACT Investigators. Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor. N Engl J Med. 2017 Mar 23;376(12):1131-1140. doi: 10.1056/NEJMoa1613627.

Gelfond D, Heltshe S, Ma C, Rowe SM, Frederick C, Uluer A, Sicilian L, Konstan M, Tullis E, Roach RN, Griffin K, Joseloff E, Borowitz D. Impact of CFTR Modulation on Intestinal pH, Motility, and Clinical Outcomes in Patients With Cystic Fibrosis and the G551D Mutation.Clin Transl Gastroenterol. 2017 Mar 16;8(3):e81. doi: 10.1038/ctg.2017.10.

Solomon GM, Francis R, Chu KK, Birket SE, Gabriel G, Trombley JE, Lemke KL, Klena N, Turner B, Tearney GJ, Lo CW, Rowe SM.Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography.JCI Insight. 2017 Mar 9;2(5):e91702. doi: 10.1172/jci.insight.91702.

Benck LR, Currica MJ, Colangelo LA, Sidney S, Dransfield MT, Mannino DM, Jacobs DR, Jr, Lewis CE, Zhu N, Washko GR, Liu K, Camethon MR, Kalhan R, Association Between Cardiorespiratory Fitness and Lung Health from Young Adulthood to Middle Age. Am J Respir Crit Care Med. 2017, Mar. 1. doi: 10.1164/rccm.2016-2089OC.

February 2017

Martinez Ch, Freeman CM, Nelson JD, Murray S, Wang X, Budoff MJ, Dransfield MT, Hokansan JE, Kaserooni EA, Kinney GL, Regan EA, Wells JM, Martinez FJ, Han MK, Curtis JL, COPDGene Investigators. GDF-15 Plasma Levels in Chronic Obstructive Pulmonary Disease are Associated with Subclinical Coronary Artery Disease. Respir Res. 2017 Feb 28;18(1):42. doi 10.1186/s12931-017-052 1-1.

Garth JM, Steele C. Innate Lung Defense During Invasive Aspergillosis: New Mechanisms. J Innate Immun. 2017 Feb 21. doi: 10.1159/000455125. [Epub ahead of print]

Rahaghi FN, Vegas-Sanchez-Ferrero G, Minhas JK, Come CE, De La Bruere I, Wells JM, Conzales G, Bhatt SP, Fenster BE, Diaz AA, Kohli P, Ross JC, Lynch DA, Dransfield MT, Bowler RP, Ledesma-Carbayo MJ, San Jose Estepar R, Washko GR, COPDGene Investigators. Ventricular Geometry From Non-Contrast Non-ECG-Gated CT Scans: An Imaging Marker of Cardiopulmonary Disease In Smokers. Acad Radiol. 2017 Feb 15. pii: S1076-6332(17)30008-9. doi: 10.1016/j.acra.2016.12.007

Heresi GA, Malin SK, Barnes JW, Tian L, Kirwan JP, Dweik RA. Abnormal Glucose Metabolism and High-Energy Expenditure in Idiopathic Pulmonary Arterial Hypertension. Ann Am Thorac Soc. 2017 Feb;14(2):190-199. doi: 10.1513/AnnalsATS.201608-605OC.

Rowe SM, McColley SA, Rietschel E, Li X, Bell SC, Konstan MW, Marigowda G, Waltz D, Boyle MP; VX09-809-102 Study Group. Lumacaftor/Ivacaftor Treatment of Patients with Cystic Fibrosis Heterozygous for F508del-CFTR. Ann Am Thorac Soc. 2017 Feb;14(2):213-219. doi: 10.1513/AnnalsATS.201609-689OC.

Bhatt SP, Han MK. Functional Small Airways Disease and FEV1 Decline in COPD: Authors' Response. Am J Respir Crit Care Med. 2017 Feb 7. doi: 10.1164/rccm.201701-0127LE. [Epub ahead of print]

Stalvey MS, Pace J, Niknian M, Higgins MN, Tarn V, Davis J, Heltshe SL, Rowe SM. Growth in Prepubertal Children With Cystic Fibrosis Treated With Ivacaftor. Pediatrics. 2017 Feb;139(2). pii: e20162522. doi: 10.1542/peds.2016-2522.

Russell DW, Janz DR, Emerson WL, May AK, Bernard GR, Zhao Z, Koyama T, Ware LB.Early exposure to hyperoxia and mortality in critically ill patients with severe traumatic injuries. BMC Pulm Med. 2017 Feb 3;17(1):29. doi: 10.1186/s12890-017-0370-1.

January 2017

Surolia R, Li FJ, Wang Z, Li H, Liu G, Zhou Y, Luckhardt T, Bae S, Liu RM, Rangarajan S, de Andrade J, Thannickal VJ, Antony VB. 3D Pulmospheres Serve As A Personalized and Predictive Multicellular Model for Assessment of Antifibrotic Drugs. JCI Insight. 2017 Jan 26;2)2):e91377. doi: 10. 1172/jci.insight.91377

Bhatt SP, Dransfield M, Cockcroft JR, Wang-Jairaj J, Midwinter DA, Rubin DB, Scott-Wilson CA, Crim C. A randomized trial of once-daily fluticasone furoate/vilanterol or vilanterol versus placebo to determine effects on arterial stiffness in COPD. Int J Chron Obstruct Pulmon Dis. 2017 Jan 19;12:351-365. doi: 10.2147/COPD.S117373. eCollection 2017.

Bernard K, Logsdon NJ, Miguel V, Benavides GA, Zhang J, Carter AB, Darley-Usmar VM, Thannickal VJ. NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-Derived 2-like 2 (Nrf2)-dependent Pathway. J Biol Chem. 2017 Jan 3. pii: jcb. M116.752261. doi: 10.1074/jbc.M116.752261 [Epub ahead of print].

Bodduluri S, Bhatt S, Hoffman EA, Newell JD, Jr. Martinez CH, Dransfield MT, Han MK, Reinhardt JM, COPDGene Investigators. Biomechanical CT Metrics Are Associated with Patient Outcomes in COPD. Thorax. 2017 Jan 2. pii:thoraxjnl-2016-209544 [Epub ahead of print].

McDonald MN, Won S, Matteisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EF, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK. Body Mass Index Change In Gastrointestinal Cancer and Chronic Obstructive Pulmonary Disease is Associated with Dedicator of Cytokinesis. Ja Cachexia Sarcopenia Muscle. 2017 Jan 2. doi: 10.1002/jcsm. 12171 [Epub ahead of print]

de Andrade, JA, Luckhardt T. What Is In A Pattern? That Which We Call Idiopathic Pulmonary Fibrosis by Any Other Pattern Would Behave Alike! Am J Respir Crit Care Med. 2017 Jan 1;195(1): 10-12. doi: 10.1164/rccm.201606-1277ED

2016 Publications

December 2016

YK Kim, LaFon D, Nahm MH. Indirect Effects of Pneumococcal Conjugate Vaccines in National Immunization Programs for Children on Adult Pneumococcal Disease. Infect Chemother. 2016 Dec. doi: 10.397/ic.2016.48.4.257.

Bhatt SP, Wells JM, Iyer AS, Kirkpatrick DP, Parekh TM, Leach LT, Anderson EM, Sanders JG, Nichols JK, Blackburn CC, Dransfield MT. Results of a Medicare Bundled Payments for Care Improvement Initiative for COPD Readmissions. Ann Am Thorac Soc. 2016 Dec 22. doi: 10.1513/AnnalsATS.201610-775BC. [Epub ahead of print]

Rowe SM. A Little CFTR Can Change A Lot: Slowing Cystic Fibrosis Progression. Lancet Respir Med. 2016 Dec 20. pii: S2213-2600(16)30465-9 [Epub ahead of print]

Cui H, Ge J, Xie N, Banerjee S, Zhou Y, Liu RM, Thannickal VJ, Liu G. miR-34a Promotes Fibrosis in Aged Lungs by Inducing Alveolar Epithelial Dysfunctions. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 15:ajplung.00335.2016. doi: 10.1152/ajplung.00335.2016. [Epub ahead of print]

Zhao XK, Che P, Cheng ML, Zhang Q, Mu M, Li H, Luo Y, Liang YD, Lou XH, Gao CQ, Jackson PL, Wells JM, Zhou Y, Hu M, Cai G, Thannickal VJ, Steele C, Blalock JE, Han X, Chen CY, Ding Q. Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism. PLoS One. 2016 Dec 2.;11(12):e0167451. doi: 10.1371/journal.pone.0167451. eCollection 2016.

Wells JM, Estepar RS, McDonald MN, Bhatt SP, Diaz AA, Bailey WC, Jacobson FL, Dransfield MT, Washko GR, Make BJ, Casaburi R, van Beek EJ, Hoffman EA, Sciurba FC, Crapo JD, Silverman EK, Hersh CP, COPDGene Investigators. Clinical, Physiologic, and Radiographic Factors Contributing to Development of Hypoxemia in Moderate to Severe COPD: A Cohort Study. BMC Pulm Med. 2016 Dec 1;16(1):169

Rahaghi FN, Wells JM, Come CE, De La Bruere IA, Bhatt SP, Ross JC, Vegas-Sánchez-Ferrero G, Diaz AA, Minhas J, Dransfield MT, San José Estépar R, Washko GR; and the COPDGene Investigators.Arterial and Venous Pulmonary Vascular Morphology and Their Relationship to Findings in Cardiac Magnetic Resonance Imaging in Smokers. J Comput Assist Tomogr. 2016 Nov/Dec;40(6):948-952.

November 2016

Chanda D, Kurundkar A, Rangarajan S, Locy M, Bernard K, Sharma NS, Logsdon NJ, Liu H, Crossman DK, Horowitz JC, De Langhe Thannickal VJ. Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis. Sci Rep. 2016 Nov 21;6:37445. doi: 10.1038/srep37445.

Hough KP, Chanda D, Duncan SR, Thannickal VJ, Deshane JS. Exosomes in Immunoregulation of Chronic Lung Diseases. Allergy. 2016 Nov 15. doi: 10.111/all.13086. [Epub ahead of print].

Mutyam V, Du M, Xue X, Keeling KM, White EL, Bostwick JR, Rasmussen L, Liu B, Mazur M, Hong JS, Falk Libby E, Liang F, Shang H, Mense M, Suto MJ, Bedwell DM, Rowe SM. Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations. Am J Respir Crit Care Med 2016 Nov 1;194(9): 1092-1103.

Surolia R, Karki S, Wang Z, Kulkarni T, Li FJ, Vohra S, Batra H, Nick JA, Duncan SR, Thannickal VJ, Steyn AJ, Agarwal A, Antony VB. Attenuated Heme Oxygenase-1 Responses Predispose the Elderly to Pulmonary Nontuberculosis Mycobacterial Infections. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L928-L940. doi: 10.1152/ajplung.00397.105

Roy B, Friesen WJ, Tomizawa Y, Leszyk JD, Shuo J, Johnson B, Dakka J, Trotta CR, Xue X, Mutyam V, Keeling KM, Mobley JA, Rowe SM, Bedwell DM, Welch EM, Jacobson A. Ataluren Stimulates Ribosomal Selection of Near-Cognate tRNAs to Promote Nonsense Suppression. Proc Natl Acad Sci U.S.A. 2016 Nov 1;113(44):12508-12513

October 2016

Bartoszewski R, Króliczewski J, Piotrowski A, Jasiecka AJ, Bartoszewska S, Vecchio-Pagan B, Fu L, Sobolewska A, Matalon S, Cutting GR, Rowe SM, Collawn JF. Codon bias and the folding dynamics of the cystic fibrosis transmembrane conductance regulator. Cell Mol Biol Lett. 2016 Oct 19;21:23. doi: 10.1186/s11658-016-0025-x. eCollection 2016.

Richard K. Albert, M.D., David H. Au, M.D., Amanda L. Blackford, Sc.M., Richard Casaburi, M.D., Ph.D., J. Allen Cooper, Jr., M.D, Gerard J. Criner, M.D., Philip Diaz, M.D., Anne L. Fuhlbrigge, M.D., Steven E. Gay, M.D., Richard E. Kanner, M.D., Neil MacIntyre, M.D., Fernando J. Martinez, M.D., Ralph J. Panos, M.D., Steven Piantadosi, M.D., Ph.D., Frank Sciurba, M.D., David Shade, J.D., Thomas Stibolt, M.D., James K. Stoller, M.D., Robert Wise, M.D., Roger D. Yusen, M.D., James Tonascia, Ph.D., Alice L. Sternberg, Sc.M., and William Bailey, M.D. A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation. N Engl J Med. 2016 Oct 27;375(17):1617-1627.

Martinez FJ, Vestbo J, Anderson JA, Brook RD, Celli BR, Cowans NJ, Crim C, Dransfield M, Kilbride S, Yates J, Newby DE, Niewoehner D, Calverley PM, SUMMIT Investigators. Effect of Fluticasone Furoate and Vilaneterol on Exacerbations of COPD in Patients with Moderate Airflow Obstruction. Am J Respir Crit Care Med. 2016 Oct 21. [Epub ahead of print]

Schroff P, Hitchcock J, Schumann C, Wells JM, Dransfield MT, Bhatt SP. Pulmonary Rehabilitation Improves Outcomes in Chronic Obstructive Pulmonary Disease Independent of Disease Burden. Ann Am Thorac Soc. 2016 Oct. 14 [Epub ahead of print.]

Chung WJ, Goeckeler-Fried JL, Havasi V, Chiang A, Rowe SM, Plyler ZE, Hong JS, Mazur M, Piazza GA, Keeton AB, White EL, Rasmussen L, Weissman AM, Denny RA, Drodsky JL, Sorscher EJ. Increasing the Endoplasmic Reticulum Poiol of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PLoS One. 2016 Oct 12;11(10):e0163615. doi: 10.1371/journal.pone.0163615. eCollection 2016.

Roy B, Friesen WJ, Tomizawa Y, Leszyk JD, Zhuo J, Johnson B, Dakka J, Trotta CR, Xue X, Mutyam V, Keeling KM, Mobley JA, Rowe SM, Bedwell DM, Welch EM, Jacobson A. Ataluren Stimulates Ribosomal Selection of Near-Cognate tRNAs to Promote Nonsense Suppression. Proceedings of the National Academy of Sciences of the United States of America. Published online before print on October 4, 2016 doi: 10.1073/pnas.1605336113

Mutyam V, Libby EF, Peng N, Hadjiliadis D, Bonk M, Solomon GM, Rowe SM. Therapeutic Benefit Observed with the CFTR Potentiator, Ivacaftor, in a CF Patient Homozygous for the W1282X CFTR Nonsense Mutation. J Cyst Fibros. 2016 Oct 1, pii: S1569-1993(16)30607-5. doi: 10.1016/j.jcf.2016.09.005 [Epub ahead of print.]

September 2016

Schaffer CC, Wang Y, Hough KP, Sawant A, Grant SC, Thannickal VJ, Zmijewski J, Ponnazhagan S, Deshane JS. Indoleamine 2,3-dioxygenase Regulates Anti-Tumor Immunity in Lung Cancer by Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment. Oncotarget. 2016 Sep 26. doi: 10.18632/oncotarget.12249 [Epub ahead of print.]

Raju SV, Kim H, Byzek SA, Tang LP, Tromble JE, Jackson P, Rasmussen L, Wells JM, Libby EF, Dohm E, Winter L, Samuel SL, Zinn KR, Blalock JE, Schoeb TR, Dransfield MT, Rowe SM. A Ferret Model of COPD-Related Bronchitis. JCI Insight. 2016 Sep 22; 1(15):e87536

Cui H, Ge J, Xie N, Banerjee S, Zhou Y, Antony VB, Thannickal VJ, Liu G. miR-34 Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence. Am J Respir Cell Mol Biol. 2016 Sep 16. [Epub ahead of Print]

Bolton CE, Quint JK, Dransfield MT. Cardiovascular Disease in COPD: Time to Quash A Silent Killer. Lancet Respir Med. 2016 Sep;4(9):687-9. doi: 10.1016/S2213-2600(16)30243-0.

Gaggar A. Weathington N. Bioactive Extracellular Matrix Fragments in Lung Health and Disease. J Clin Invest. 2016 Sep 1:126(9):3176-84. doi 10.1272/JCI83147. Epub 2016 Sep 1.

Bhatt SP. Hidden in Plain Sight: Lung Impairment in Ischemic Heart Disease. Am J Respir Crit Care Med. 2016 Sep 1;194(5):528-30. doi: 10.1164/rccm.201607-1521ED.

Raju SV, Lin VY, Liu L, McNicholas CM, Karki S, Sloane PA, Tang L, Jackson PL, Wang W, Wilson L, Macon KJ, Mazur M, Kappes J, DeLucas LJ, Barnes S, Kirk K, Tearney GT, Rowe SM. The CFTR Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating CFTR Inhibition by Cigarette Smoke. Am J Respir Cell Mol Biol. 2016 Sep 1. [Epub ahead of print]

August 2016

Sanders YY, Liu H, Scruggs AM, Duncan SR, Huang SK, Thannickal VJ. Epigenetic Regulation of Caveolin-1 Gene Expression in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2016 Aug 25 [Epub ahead of print]

Dransfield MT, Kunisaki KM, Strand, MJ, Anzueto A, Bhatt SP, Bowler RP, Cringer GJ, Curtis JL, Hanania NA, Nath H, Putcha N, Roark SE, Wan ES, Washko GR, Wells JM, Wendt CH, Make BJ, COPDGene Investigators. Acute Exacerbations and Lung Function Loss in Smokers With and Without COPD. Am J Respir Crit Care Med. 2016 Aug 24 [Epub ahead of print].

Gaggar A. Patel RP. There Is Blood in the Water: Hemolysis, Hemoglobin, and Heme in Acute Lung Injury. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 19: ajplung.00312.2016. doi:10.1152/ajplung.00312.2016

Chen H, Qu J, Huang X, Kurundkar A, Zhu L, Yang N, Venado A, Ding Q, Liu G, Antony VB. Thannickal VJ, Zhou Y. Mechanosensing by the α6-integrin Confers an Invasive Fibroblast Phenotype and Mediates Lung Fibrosis. Nat. Commun. 2016 Aug 18;7:12564. doi: 10.1038/ncomms12564.

Oh GY, Hamm J, Xu X, Genschmer K, Zhong M, Lebensburger J, Margues MB, Kerby JD, Pittet JF, Gaggar A, Patel RP. Absorbance and Redox-Based Approaches for Measuring Free Heme and Free Hemoglobin in Biological Matrices. Redox Biol. 2016 Aug 10;9:167-177. doi: 10.1016/j.redox.2016.08.003. [Epub ahead of print]

July 2016

Lewis WE, Malarkey ED, Tritschler D, Bower R, Pasek RC, Birket SE, Saunier S, Antignac C, Knowles ME, Leigh MW, Zariwala MA, Challa AK, Kesterson RA, Rowe SM, Drummond IA, Parant JM, Hildebrandt F, Porter ME, Yoder BK, Berbari NF. Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. PLos Genet, 2016 Jul 29.

Dilektasi AG, Porszasz J, Casaburi R, Stringer WW, Bhatt SP, Pak Y, Rossiter HB, Washko G, Castaldi PJ, San Jose Estepar R, Hansen JE, COPDGene Investigators. A Novel Spirometric Measure Identifies Mild Chronic Obstructive Pulmonary Disease Unidentified by Standard Criteria. Chest. 2016 Jul 21. [Epub ahead of print.]

Srivastava RK, Li C, Wang Y, Weng Z, Elmets CA, Harrod KS, Deshane JS, Athar M. Activating Transcription Factor 4 Underlies the Pathogenesis of Arsenic-Mediated Impairment of Macrophage Innate Immune Functions. Toxicol Appl Pharmacol. 2016 Jun 13.

Pascoe SJ, Lipson DA, Locantore N, Barnacle H, Brealey N, Mohindra R, Dransfield MT, Pavord I, Barnes N. A Phase III Randomized Controlled Trial of Single-Dose Triple Therapy in COPD: The IMPACT Protocol. Eur Respir J. 2016 Jul. 13.

Lipworth B, Wedzicha J, Devereux G, Vestbo J, Dransfield MT. Beta-Blockers in COPD: Time for Reappraisal. Eur Respir J. 2016 Jul 7.

June 2016

Kurundkar A. Thannickal VJ. Redox Mechanisms in Age-Related Lung Fibrosis. Redox Biol. 2016 Jun 25.

Mou H. Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, Harrington J, Lapey A, Channick C, Keyes C, Freund A, Artandi S, Mense M, Rowe S, Engelhart JF, Hsu YC, Rajagopal J. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell, 2016 Jun 15. pii: S1934-5909(16)300096-0. doi: 10.1016/j.stem.201605.012.

Wells JM. Farris RF, Gosdin TA, Dransfield MT, Wood ME, Bell SC, Rowe SM. Pulmonary Artery Enlargement and Cystic Fibrosis Pulmonary Exacerbations: A Cohort Study. Lancet Respir Med. 2016 Jun 9. pii: S2213-2600(16)30105-9. doi: 10.1016/S213-2600(16)30105-9.

Bhatt SP, Connett JE, Voelker H, Lindberg SM, Westfall E, Wells JM, Lazarus SC, Criner GJ, Dransfield MT. β-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (βLOCK COPD): A Randomized Controlled Study Protocol. BMJ Open. 2016 June 7;6(6);e012292. doi: 10.1136/bmjopen-2016-012292.

May 2016

Kulkarni T. de Andrade JA. Zhou Y. Luckhardt TR, Thannickal VJ. Alveolar Epithelial Disintegrity in Pulmonary Fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016 May 27:ajplung.00115.2016. doi: 10.1152/ajplung.00115.2016 [Epub ahead of print]

Han MK, Martinez CH, Au DH, Bourbeau J, Boyd CM, Branson R, Criner GJ, Kalhan R, Kallstron TJ, King A, Krishnan JA, Lareau SC, Lee TA, Lindell K, Mannino DM, Martinez FJ, Meldrum C, Press VG, Thomashow B, Tycon Lm Sullican JL, Walsh J, Wilson KC, Wright J, Yawn B, Zueger PM, Bhatt SP, Dransfield MT. Meeting the Challenge of COPD Care Delivery in the USA: A Multi Provider Perspective. Lancet Respir Med. 2016 May 12. pii: S2213-2600(16)00094-1. doi: 10.1016/S2213-2600(16)00094-1..

Solomon GM, Hathorn H, Liu B, Raju SV, Reeves G, Acosta EP, Dransfield MT, Rowe SM. Pilot Evaluation of Ivacaftor for Chronic Bronchitis. Lancet Respir. Med. pii: S2213-2600(16)30047-9. doi: 10.1016/S2213-2600(16)30047-9.

Kim V, Zhao H, Boriek AM, Anzueto A, Soler X, Bhatt SP, Rennard SI, Wise R, Comellas A, Ramsdell JW, Kinney GL, Han MK, Martinez CH, Yen A, Black-Shinn J, Porszasz J Criner GJ, Hanania NA, Sharafkhaneh A, Crapo JD, Make BJ, Silverman EK, Curtis JL, COPDGene Investigators. Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2016 May 9.

Yang Y. Shi R. Cao Z. Cheng G. VP01 Mediates Oxidation of LDL and Formation of Foam Cells. Oncotarget. 2016 May 5. doi: 10.18632/oncotarget.9193.

Sciurba FC, Criner GJ, Strange C, Shah PL, Michaud G, Connolly TA, Deslee G, Delage A, Marquette CH, Krishna G, Kalhan R, Ferguson JS, Jantz M, Maldonado F, McKenna R, Majid A, Rai N, Gay S, Dransfield MT, Angel L, Maxfield R, Herth FJ, Wahidi MM, Mehta A, Slebos DJ, RENEW Research Group. Effect of Endobrochial Coils vs Usual Care on Exercise Tolerance in Patients with Severe Emphysema: The RENEW Randomized Clinical Trial. JAMA. 2016 May.

April 2016

Mutyam V, Du M, Xue X, Keeling KM, White EL, Bostwick JR, Rasmussen L, Liu B, Mazur M, Hong JS, Falk Libby E, Liang F, Shang H, Mense M, Suto MJ, Bedwell DM, Rowe SM. Discovery of Clinically Approved Agents That Promote Suppression of CFTR Nonsense Mutations. Am J Respir Crit Care Med. 2016 Apr 22.

Solomon GM, Raju SV, Dransfield MT, Rowe SM. Therapeutic Approaches to Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis. Ann Am Thorac Soc. 2016 Apr;13 Suppl 2:S169-76.

Iyer AS, Dransfield MT. Serum Eosinophils as a COPD Biomarker: Ready for Prime Time? Lancet Respir Med. 2016 Apr 7.

March 2016

Quon BS. Rowe SM. New and Emerging Targeted Therapies for Cystic Fibrosis. BMJ. 2016 Mar 30;325:i859.

Hecker L. Thannickal VJ. Getting to the Core of Fibrosis: Targeting Redox Imbalance in Aging. Ann Transl Med. 2016 Mar;4(5):93.

Birket SE, Chu KK, Houser GH, Liu L, Fernandez Cm, Solomon GM, Lin V, Shastry S, Mazur M, Sloane P, Hanes J, Grizzle WE, Sorscher EJ, Teamey GJ, Rowe SM. Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 11:ajplung.00395.2015.

Raghu G, Scholand MB, de Andrade J, Lancaster L, Mageto Y, Goldin, Brown KK, Flaherty KR, Wencel M, Wanger J, Neff T, Valone F, Stauffer J, Porter S. FG-3019 Anti-Connective Tissue Growth Factor Monoclonal Antibody: Results of an Open-Label Clinical Trial in IPF. Eur Respir D. 2016 Mar. 10.

Walker MM, Novak L, Widener R, Grubbs JA, King J, Hale JY, Ochs MM, Myers LE, Briles DE, Deshane J. PcpA Promotes Higher Levels of Infection and Modulates Recruitment of Myeloid-Derived Suppressor Cells during Pneumococcal Pneumonia. J Immunol. 2016 Mar 1;196(5):2239-48. doi: 10.4049/jimmunol.1402518.

Rangarajan S, Locy ML, Luckhardt TR, Thannickal VJ. Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where To Now? Drugs. 2016 Mar;76(3):291-300. doi: 10.1007/s40265-015-0523-6.

February 2016

Brown AT, Hitchcock J, Schumann C, Wells JM, Dransfield MT, Bhatt SP. Determinants of Successful Completion of Pulmonary Rehabilitation in COPD. Int J Chron Obstruct Pulmon Dis. 2016 Feb 25.

Larson-Casey JL, Deshane JS, Ryan AJ, Thannickal VJ, Carter AB. Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Immunity. 2016 Feb 22. pii: S1074-7613(16)00002-9. doi: 10.1016/j.immuni.2016.01.001.

Kurundkar AR, Kurundkar D, Rangarajan S, Locy ML, Zhou Y, Liu RM, Zmijewski J, Thannickal VJ. The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury. FASEB J. 2016 Feb 16. pii: fj.201500173. [Epub ahead of print]

Liu RM, Eldridge S, Watanabe N, Deshane J, Kuo HC, Jiang C, Wang Y, Liu G, Schwiebert L, Miyata T, Thannickal VJ. Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L328-36. doi: 10.1152/ajplung.00217.2015. Epub 2015 Dec 23.

Bhatt SP. Increased Costs of the Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome. One Syndrome for the Price of Two? Ann Am Thorac Soc. 2016 Feb;13(2):158-9. doi: 10.1513/AnnalsATS.201512-795ED. No abstract available.

Busch R, Han MK, Bowler RP, Dransfield MT, Wells JM, Regan EA, Hersh CPRisk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. ; COPDGene Investigators. BMC Pulm Med. 2016 Feb 10;16(1):28. doi: 10.1186/s12890-016-0191-7.

Bhatt SP, Terry NL, Nath H, Zach JA, Tschirren J, Bolding MS, Stinson DS, Wilson CG, Curran-Everett D, Lynch DA, Putcha N, Soler X, Wise RA, Washko GR, Hoffman EA, Foreman MG, Dransfield MT;Association Between Expiratory Central Airway Collapse and Respiratory Outcomes Among Smokers. Genetic Epidemiology of COPD (COPDGene) Investigators.JAMA. 2016 Feb 2;315(5):498-505. doi: 10.1001/jama.2015.19431.

January 2016

Sharma NS, Peters T, Kulkarni T, Hoopes CW, Bellot SC, Wille KM, Diaz-Guzman E. Flexible Bronchoscopy Is Safe and Effective in Adult Subjects Supported With Extracorporeal Membrane Oxygenation. Respir Care. 2016 Jan 26. pii: respcare.04456. [Epub ahead of print]

Bhatt SP, Soler X, Wang X, Murray S, Anzueto AR, Beaty TH, Boriek AM, Casaburi R, Criner GJ, Diaz AA, Dransfield MT, Curran-Everett D, Galbán CJ, Hoffman EA, Hogg JC, Kazerooni EA, Kim V, Kinney GL, Lagstein A, Lynch DA, Make BJ, Martinez FJ, Ramsdell JW, Reddy R, Ross BD, Rossiter HB, Steiner RM, Strand MJ, van Beek EJ, Wan ES, Washko GR, Wells JM, Wendt CH, Wise RA, Silverman EK, Crapo JD, Bowler RP, Han MK; COPDGene Investigators. Association Between Functional Small Airways Disease and FEV1 Decline in COPD. Am J Respir Crit Care Med. 2016 Jan 25. [Epub ahead of print]

Bratcher PE, Rowe SM, Reeves G, Roberts T, Szul T, Harris WT, Tirouvanziam R, Gaggar A. Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor. J Cyst Fibros. 2016 Jan;15(1):67-73. doi: 10.1016/j.jcf.2015.02.010. Epub 2015 Mar 11.

Kulkarni T, O'Reilly P, Antony VB, Gaggar A, Thannickal VJ.Matrix Remodeling in Pulmonary Fibrosis and Emphysema. Am J Respir Cell Mol Biol. 2016 Jan 7. [Epub ahead of print]

Bhatt SP, Wells JM, Kinney GL, Washko GR Jr, Budoff M, Kim YI, Bailey WC, Nath H, Hokanson JE, Silverman EK, Crapo J, Dransfield MT; COPDGene Investigators. β-Blockers are associated with a reduction in COPD exacerbations. Thorax. 2016 Jan;71(1):8-14. doi: 10.1136/thoraxjnl-2015-207251.

2015 Publications

December 2015

Liu RM, Desai LP. Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis. Redox Biol. 2015 Dec;6:565-77. doi: 10.1016/j.redox.2015.09.009.

He C, Larson-Casey JL, Gu L, Ryan AJ, Murthy S, Carter AB.Cu,Zn-SOD-mediated Redox Regulation of Jmjd3 Modulates Macrophage Polarization and Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2015 Dec 23. [Epub ahead of print]

Raju SV, Solomon GM, Dransfield MT, Rowe SM. Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis and Other Diseases of Mucus Clearance. Clin Chest Med. 2016 Mar;37(1):147-58. doi: 10.1016/j.ccm.2015.11.003. Epub 2015 Dec 24.

He C, Carter AB. The Metabolic Prospective and Redox Regulation of Macrophage Polarization. J Clin Cell Immunol. 2015 Dec;6(6)

Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, , Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK; ECLIPSE Investigators. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. COPDGene Investigators. BMC Genet. 2015 Dec 3;16:138. doi: 10.1186/s12863-015-0299-4.

Noerager BD, Xu X, Davis VA, Jones CW, Okafor S, Whitehead A, Blalock JE, Jackson PL.. A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation. Inflammation. 2015 Dec;38(6):2279-87. doi: 10.1007/s10753-015-0213-2.

Baumann AW, Kohler C, Kim YI, Cheong J, Hendricks P, Bailey WC, Harrington KF. Differences in Electronic Cigarette Awareness, Use History, and Advertisement Exposure Between Black and White Hospitalized Cigarette Smokers. J Cancer Educ. 2015 Dec;30(4):648-54. doi: 10.1007/s13187-014-0767-y.

November 2015

Cui H, Banerjee S, Xie N, Ge J, Liu RM, Matalon S, Thannickal VJ, Liu G. miR-27a-3p is a Negative Regulator of Lung Fibrosis by Targeting Myofibroblast Differentiation. Am J Respir Cell Mol Biol. 2015 Nov 24. [Epub ahead of print]

Pennathur S, Vivekanandan-Giri A, Locy ML, Kulkarni T, Zhi D, Zeng L, Byun J, de Andrade JA, Thannickal VJ. Oxidative Modifications of Protein Tyrosyl Residues are Increased in Plasma of Human Subjects with Interstitial Lung Disease. Am J Respir Crit Care Med. 2015 Nov 17. [Epub ahead of print] Xie N, Liu G. ncRNA-regulated immune response and its role in inflammatory lung diseases. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1076-87. doi: 10.1152/ajplung.00286.2015. Review. October 2015

Wells JM, Jackson PL, Viera L, Bhatt SP, Gautney J, Handley G, King RW, Xu X, Gaggar A, Bailey WC, Dransfield MT, Blalock JE. A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015 Oct 15;192(8):934-42. doi: 10.1164/rccm.201503-0543OC.

September 2015

Venado A, Wille K, Belott SC, Diaz-Guzman E. Unexplained hemolysis in patients undergoing ECMO: beware of hypertriglyceridemia. Perfusion. 2015 Sep;30(6):465-8. doi: 10.1177/0267659114557693.

Hendricks PS, Cases MG, Thorne CB, Cheong J, , Kohler CL, Bailey WC. Hospitalized smokers' expectancies for electronic cigarettes versus tobacco cigarettes. Addict Behav. 2015 Feb;41:106-11. doi: 10.1016/j.addbeh.2014.09.031. Epub 2014 Sep 28.

Teerapuncharoen K, Sharma NS, Barker AB, Wille KM, Diaz-Guzman E. Successful Treatment of Severe Carbon Monoxide Poisoning and Refractory Shock Using Extracorporeal Membrane Oxygenation. Respir Care. 2015 Sep;60(9):e155-60. doi: 10.4187/respcare.03990.

Akhter H, Ballinger C, Liu N, van Groen T, Postlethwait EM, Liu RM. Cyclic Ozone Exposure Induces Gender-Dependent Neuropathology and Memory Decline in an Animal Model of Alzheimer's Disease.

August 2015

Murthy S, Larson-Casey JL, Ryan AJ, He C, Kobzik L, Carter AB. Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure. FASEB J. 2015 Aug;29(8):3527-36. doi: 10.1096/fj.15-271304.

Surolia R, Karki S, Kim H, Yu Z, Kulkarni T, Mirov SB, Carter AB, Rowe SM, Matalon S, Thannickal VJ, Agarwal A, Antony VB. Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L280-92. doi: 10.1152/ajplung.00097.2015.

Wheatley CM, Baker SE, Morgan MA, Martinez MG, Liu B, Rowe SM, Morgan WJ, Wong EC, Karpen SR, Snyder EM. Moderate intensity exercise mediates comparable increases in exhaled chloride as albuterol in individuals with cystic fibrosis. Respir Med. 2015 Aug;109(8):1001-11. doi: 10.1016/j.rmed.2015.05.018.

July 2015

Kong MY, Whitley RJ, Peng N, Oster R, Schoeb TR, Sullender W, Ambalavanan N, Clancy JP, Gaggar A, Blalock JE. Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo. Viruses. 2015 Jul 30;7(8):4230-53. doi: 10.3390/v7082817.

May 2015

Eddens T, Elsegeiny W, Nelson MP, Horne W, Campfield BT, Steele C, Kolls JK. Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection. J Immunol. 2015 Jul 1;195(1):185-93. doi: 10.4049/jimmunol.1403162. Epub 2015 May 20.

Tan Z, Xie N, Cui H, Moellering DR, Abraham E, Thannickal VJ, Liu G. Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism. J Immunol. 2015 Jun 15;194(12):6082-9. doi: 10.4049/jimmunol.1402469. Epub 2015 May 11. MMP generated matrikines. Wells JM, Gaggar A, Blalock JE. Matrix Biol. 2015 May-Jul;44-46:122-9. doi: 10.1016/j.matbio.2015.01.016.

April 2015

Wells JM, Iyer AS, Rahaghi FN, Bhatt SP, Gupta H, Denney TS, Lloyd SG, Dell'Italia LJ, Nath H, Estepar RS, Washko GR, Dransfield MT.Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary disease. Circ Cardiovasc Imaging. 2015 Apr;8(4). pii: e002546. doi: 10.1161/CIRCIMAGING.114.002546. J Pediatr. 2015 Mar;166(3):531-7.e13. doi: 10.1016/j.jpeds.2014.09.052.

February 2015

Sanders YY, Liu H, Liu G, Thannickal VJ. Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence. Free Radic Biol Med. 2015 Feb;79:197-205. doi: 10.1016/j.freeradbiomed.2014.12.008.

Deshane JS, Redden DT, Zeng M, Spell ML, Zmijewski JW, Anderson JT, Deshane RJ, Gaggar A, Siegal GP, Abraham E, Dransfield MT, Chaplin DD. Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2015 Feb;135(2):413-424.e15. doi: 10.1016/j.jaci.2014.08.040. Erratum in: J Allergy Clin Immunol. 2015 Apr;135(4):1092.

January 2015

Huang WT, Akhter H, Jiang C, MacEwen M, Ding Q, Antony V, Thannickal VJ, Liu RM. Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis. Exp Gerontol. 2015 Jan;61:62-75. doi: 10.1016/j.exger.2014.11.018.

Stein A, Kraus DW, Doeller JE, Bailey SM. Inhalation exposure model of hydrogen sulfide (H₂S)-induced hypometabolism in the male Sprague-Dawley rat. Methods Enzymol. 2015;555:19-35. doi: 10.1016/bs.mie.2014.11.019. Epub 2015 Jan 8.

2014 Publications

December 2014

Honavar J, Doran S, Oh JY, Steele C, Matalon S, Patel RP.Nitrite therapy improves survival postexposure to chlorine gas.Am J Physiol Lung Cell Mol Physiol. 2014 Dec 1;307(11):L888-94. doi: 10.1152/ajplung.00079.2014.

November 2014

Harrington KF, Hull NC, Akindoju O, Kim YI, Hendricks PS, Kohler C, Bailey WC. Electronic cigarette awareness, use history, and expected future use among hospitalized cigarette smokers. Nicotine Tob Res. 2014 Nov;16(11):1512-7. doi: 10.1093/ntr/ntu054.

Park DW, Jiang S, Liu Y, Siegal GP, Inoki K, Abraham E, Zmijewski JW. GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L735-45. doi: 10.1152/ajplung.00165.2014.

Bratcher PE, Gaggar A. Factors influencing the measurement of plasma/serum surfactant protein D levels by ELISA. PLoS One. 2014 Nov 3;9(11):e111466. doi: 10.1371/journal.pone.0111466. eCollection 2014.

Bhatt SP, Wells JM, Kim V, Criner GJ, Hersh CP, Hardin M, Bailey WC, Nath H, Kim YI, Foreman MG, Stinson DS, Wilson CG, Rennard SI, Silverman EK, Make BJ, Dransfield MT; COPDGene Investigators.Radiological correlates and clinical implications of the paradoxical lung function response to β₂ agonists: an observational study.Lancet Respir Med. 2014 Nov;2(11):911-8. doi: 10.1016/S2213-2600(14)70185-7.

October 2014

Hu M, Che P, Han X, Cai GQ, Liu G, Antony V, Luckhardt T, Siegal GP, Zhou Y, Liu RM, Desai LP, O'Reilly PJ, Thannickal VJ, Ding Q. Therapeutic targeting of SRC kinase in myofibroblast differentiation and pulmonary fibrosis. J Pharmacol Exp Ther. 2014 Oct;351(1):87-95. doi: 10.1124/jpet.114.216044

Werner JL, Steele C. Innate receptors and cellular defense against pulmonary infections. J Immunol. 2014 Oct 15;193(8):3842-50. doi: 10.4049/jimmunol.1400978. Review.

Bhatt SP, Wells JM, Dransfield MT.. Cardiovascular disease in COPD: a call for action.Lancet Respir Med. 2014 Oct;2(10):783-5. doi: 10.1016/S2213-2600(14)70197-3. No abstract available.

August 2014

Schwiebert LM, Estell K, Meadows T, Thannickal VJ, Rowe S, Sorscher EJ, Harris WT, Gaggar A, Dransfield M, de Andrade JA. Development and maintenance of a biospecimen repository for clinical samples derived from pulmonary patients. Clin Transl Sci. 2014 Aug;7(4):336-41. doi: 10.1111/cts.12161.

Dransfield MT, Feldman G, Korenblat P, LaForce CF, Locantore N, Pistolesi M, Watkins ML, Crim C, Martinez FJ. Efficacy and safety of once-daily fluticasone furoate/vilanterol (100/25 mcg) versus twice-daily fluticasone propionate/salmeterol (250/50 mcg) in COPD patients.Respir Med. 2014 Aug;108(8):1171-9. doi: 10.1016/j.rmed.2014.05.008.

July 2014

Marques MB, Wille KM, Ren Z, Sheth M, McGiffin DC. Successful pulmonary thromboendarterectomy in a patient with sickle cell disease treated with a single preoperative red blood cell exchange.Transfusion. 2014 Jul;54(7):1901-2. doi: 10.1111/trf.12651. No abstract available.

June 2014

Desai LP, Zhou Y, Estrada AV, Ding Q, Cheng G, Collawn JF, Thannickal VJ. Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein.J Biol Chem. 2014 Jun 27;289(26):18270-8. doi: 10.1074/jbc.M114.562249.

Thannickal VJ, Henke CA, Horowitz JC, Noble PW, Roman J, Sime PJ, Zhou Y, Wells RG, White ES, Tschumperlin DJ. Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute. Am J Pathol. 2014 Jun;184(6):1643-51. doi: 10.1016/j.ajpath.2014.02.003. Review.

May 2014

Abdul Roda M, Sadik M, Gaggar A, Hardison MT, Jablonsky MJ, Braber S, Blalock JE, Redegeld FA, Folkerts G, Jackson PL. Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation. PLoS One. 2014 May 16;9(5):e97594. doi: 10.1371/journal.pone.0097594. eCollection 2014

April 2014

Bai G, Hock TD, Logsdon N, Zhou Y, Thannickal VJ. A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β.Gene. 2014 Apr 25;540(1):62-7. doi: 10.1016/j.gene.2014.02.026.

March 2014

Bhatt SP, Kim YI, Wells JM, Bailey WC, Ramsdell JW, Foreman MG, Jensen RL, Stinson DS, Wilson CG, Lynch DA, Make BJ, Dransfield MT. . FEV(1)/FEV(6) to diagnose airflow obstruction. Comparisons with computed tomography and morbidity indices. Ann Am Thorac Soc. 2014 Mar;11(3):335-41. doi: 10.1513/AnnalsATS.201308-251OC.

February 2014

Courville CA, Tidwell S, Liu B, Accurso FJ, Dransfield MT, Rowe SM. Acquired defects in CFTR-dependent β-adrenergic sweat secretion in chronic obstructive pulmonary disease.Respir Res. 2014 Feb 25;15:25. doi: 10.1186/1465-9921-15-25.

Raju SV, Tate JH, Peacock SK, Fang P, Oster RA, Dransfield MT, Rowe SM. Impact of heterozygote CFTR mutations in COPD patients with chronic bronchitis.Respir Res. 2014 Feb 11;15:18. doi: 10.1186/1465-9921-15-18.

January 2014

Bhatt SP, Cole AG, Wells JM, Nath H, Watts JR, Cockcroft JR, Dransfield MT.Determinants of arterial stiffness in COPD. BMC Pulm Med. 2014 Jan 4;14:1. doi: 10.1186/1471-2466-14-1.

Sharma NS, Wille KM, Hoopes CW, Diaz-Guzman E. Acute demyelinating polyneuropathy after lung transplantation: guillain-barré syndrome or tacrolimus toxicity? Case Rep Transplant. 2014;2014:685010. doi: 10.1155/2014/685010.