Suzanne LapiSuzanne E. Lapi, PhD
Grant Number: 1P01CA221775-01A1
Title: Precision Delivery and Imaging to Enhance Solid Tumor Therapy
Sponsor:  NIH/NCI
5 Year subaward totaling: $3,954,322

Project Narrative: The overall goal of the proposed research seeks to use imaging strategies to overcome current limitations to effective delivery of antibody-drug conjugates and radioimmunotherapies into solid tumors. This includes the first clinical trial to evaluate a PET-based 89Zr-labeled antibody for tumor imaging that is actively pumped across the tumor endothelium to deliver the highest levels to solid tumors. This Project also provides for a clinical trial to treat metastatic solid tumors, also for the first time, using novel caveolae-targeted drug conjugates.