Anna G. Sorace, Ph.D.

PI: Anna Sorace
Sponsor: NIH/National Cancer Institute
Title: Personalizing immunotherapy in HER2+ breast cancer through quantitative imaging
Project Period: 3/1/2020 – 2/29/2024 (4) year award
Funding: $1,633,018

Project Narrative:
We propose to integrate advanced—but clinically relevant—imaging with mathematical modeling to personalize, guide, and improve the overall efficacy of anti-HER2 targeted therapy with immunotherapy in murine models of HER2+ breast cancer. Our goal is to provide an approach to exploit the biological and vascular alterations in response to anti-cancer therapies to identify optimal combinations, thereby improving treatment efficacy (while minimizing toxicity) and increasing tumor kill; this has high likelihood to improve patient outcome.