Arun Paul uab radiation oncologyAssistant Professor

Areas of Interest:
Radiation Oncology Research

Physical address
Hazelrig Salter Radiation Oncology Center
1700 6th Avenue South
Birmingham, AL 35233

Administrative Contact
Alexxi Howell
205.996.4634
howellan@uab.edu

Education and Postdoctoral Training

Bachelor of Science at Lake Forest College, 2005
M.D., Ph.D, Rosalind Franklin University of Medicine and Science, 2005-2012  
Internal Medicine Preliminary Year, Saint Francis Hospital, 2012-2013
Radiation Oncology Residency, Detroit Medical Center/Wayne State University, School of Medicine, 2013-2017

Research Interests

"I began my research training studying the role of telomeric sequences in chromosomal separations during anaphase. I designed a unique PCR assay that can detect telomeric fusions by circumventing the challenges of secondary structure formations during the separation of GC-rich sequences. The fundamental biological theme of my doctoral work entailed delineating the host mechanisms pirated by Kaposi’s sarcoma associated herpes virus (KSHV) and how that leads to KS pathogenesis. I combined the fields of basic virology, tumor microenvironment, and molecular biology for my thesis work and discovered the induction of COX-2/PGE2/EP receptor pro-inflammatory axis, associated signaling through Ca2+, Src, PI3K, PKC, and NFB, and consequent transcriptional manipulation by KSHV. I then demonstrated the anti-proliferative effects of COX-2 inhibitors on KSHV and EBV associated lymphomas and the synergistic anti-cancer effects when combined with specific antagonists for EP receptors. The translational significance of my work was in identifying EP receptors as novel targets for treating KSHV associated malignancies in conjunction with FDA approved COX-2 inhibitors.I began my research training studying the role of telomeric sequences in chromosomal separations during anaphase. I designed a unique PCR assay that can detect telomeric fusions by circumventing the challenges of secondary structure formations during the separation of GC-rich sequences. The fundamental biological theme of my doctoral work entailed delineating the host mechanisms pirated by Kaposi’s sarcoma associated herpes virus (KSHV) and how that leads to KS pathogenesis. I combined the fields of basic virology, tumor microenvironment, and molecular biology for my thesis work and discovered the induction of COX-2/PGE2/EP receptor pro-inflammatory axis, associated signaling through Ca2+, Src, PI3K, PKC, and NFB, and consequent transcriptional manipulation by KSHV. I then demonstrated the anti-proliferative effects of COX-2 inhibitors on KSHV and EBV associated lymphomas and the synergistic anti-cancer effects when combined with specific antagonists for EP receptors. The translational significance of my work was in identifying EP receptors as novel targets for treating KSHV associated malignancies in conjunction with FDA approved COX-2 inhibitors."

My current research is focused on understanding the:
a) Role of chronic retro-viral infections in the evolution of oncogenic mutations.
b) Mechanisms underlying the pathogenesis of non-AIDS defining malignancies.

Awards and Honors

2016 2nd Prize for Best Talk: Michigan Radiological Society’s Annual Radiation Oncology Resident Meeting. Plymouth, MI.
2012 Invited Author: “Featured New Investigator series review article” in Translation Research journal by “The Central Society for Clinical Research”.
2012 John J. Sheinin Research Award, Rosalind Franklin University of Medicine and Science scholarship award for outstanding achievement in research performed as a medical student, North Chicago, IL
2011 Central Society for Clinical Research Trainee Travel Award, Chicago, IL
2010 Rosalind Franklin University of Medicine and Science Dean’s Award for the Best Doctoral (Ph.D) thesis, North Chicago, IL
2009 Sigma Xi Grant In Aid Award/Fellowship,
2009. Sigma Xi Grant-in-aid grant G2009101428.
2009 Honorable Mention Award in Medicine and Public Health Category by American Association of the Advancement of Science (AAAS) Student Poster Competition, Chicago, IL.
2009 M.D., Ph.D. Award for Best Poster. Rosalind Franklin University of Medicine and Science, North Chicago, IL
2009 California Cancer Federation Scholarship Award, Rosalind Franklin University of Medicine and Science, North Chicago, IL
2005 Fredericka L. Stahl Memorial Award for Excellence in Science-Biology, Lake Forest College, IL
2005 Undergraduate Poster Competition Winner, Annual Society for Neuroscience Chicago Chapter Scientific Meeting, Chicago, IL
2005 Nancy Chang Lee Academic Scholarship, Lake Forest College, IL
2003-2005 John H. & Margaret Veeck Krehbiel Presidential Scholarship, Lake Forest College, IL
2003-2004 Richter Apprentice Scholar, Dean’s List, Lake Forest College, IL
2001-2005 Deerpath Natural and Mathematical Sciences Scholarship, Lake Forest College, IL
2001-2005 Annual Lake Forest College Grant, Lake Forest College, IL

Publications