JunLi Updated 2013Instructor of Medicine

Division of Clinical Immunology and Rheumatology

Address:

Shelby Building, Suite 337
1825 University Boulevard
Birmingham, AL 35294-2182

Telephone: (205) 934-8909

Fax: (205) 996-6788

Email: junli@uabmc.edu

 

Education:

M.D. Sun Yat-sen University, School of Medicine, Guangzhou, China 1997
Ph.D. (Physiology): University of Alabama at Birmingham, 2008
Postdoctoral Fellow: Department of Medicine, Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, 2012

 

Research Interests

Macrophages in pathogenesis of rheumatoid arthritis (RA) and development of novel macrophage target therapies in RA; Identification of novel markers (death receptor, et al) of M1 inflammatory macrophages in RA;


figure-1

Roles of fucosylation in regulation of macrophage differentiation, apoptosis, antigen presentation, cytoskeleton rearrangement, and how these are linked to pathogenesis of RA; efficacy and mechanisms of fucosylation inhibitors in the treatment of RA and other autoimmune diseases;

figure-2-2

Studies of inflammatory IRF5+ macrophages and GM-CSF+ CD4 T cell interaction in RA using synovial fluid and PBMC from RA subjects. 


Figure-3-2

 

Publications

Click here for a more complete list of publications. Below are selected papers


Li J,
Hsu HC, Ding Y, Li H, Wu Q, Yang P, Luo B, Rowse AL, Spalding DM, Bridges SL Jr, Mountz JD. 2014. Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritis. Arthritis Rheumatol. 66(9):2368-79. PMC4146698


Li J, Yang PA, Wu Q, Li, H, Ding Y, Hsu H-C, Spalding DM, and Mountz JD. 2013. Death receptor 5-targeted depletion of interleukin 23 producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritis. Arthritis & Rheum 65(10), 2594-2605. (Supplementary Table). PMC3993980


Li J
, Hsu H-C, and Mountz JD.  2012. Managing Macrophage in Rheumatoid Arthritis by Reform or Removal. Curr Rheumatol Rep. 14 (5):445-54. PMID: 22855296


Li J
, Hsu H-C, Yang P, Wu Q, Li H,  Edgington LE, Bogyo M, Kimberly RP, and Mountz JD.  2012. Treatment of Arthritis by Macrophage Depletion and Immunomodulation: Testing an Apoptosis-Mediated Therapy in a Humanized Death Receptor Mouse Model. Arthritis Rheum. 64(4):1098-109.  PMID: 22006294

 

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