Gaffo, Angelo L., MD, MSPH

GaffoAssociate Professor of Medicine
Associate Director, Rheumatology Fellowship Training Program



Shelby Bldg., room 306

Telephone:(205) 975-6409



MD: Universidad Peruana Cayetano Heredia, 1991-1999, Lima, Peru 
Residency: Internal Medicine, University of Alabama at Birmingham, 2002-2005

Rheumatology, University of Alabama at Birmingham, 2005-2007
Quality Improvement, National VA Quality Scholars Program at the Birmingham VA Medical Center, 2007-2009

Postgraduate: MSPH in Epidemiology, University of Alabama at Birmingham School of Public Health, 2006-2008)


Clinical Interests

  • General Rheumatology Practice with emphasis in connective tissue diseases and metabolic crystal disorders.
  • Quality improvement in musculoskeletal disease.
  • Care of patients with vasculitis


Research interests

  • Epidemiology of hyperuricemia and gout, with focus on their association with ethnic, dietary, and cardiovascular factors
  • Quality of care in arthritis and rheumatic diseases
  • Clinical and therapeutic aspects of vasculitis care



Click here for a more complete list of publications. Below are selected papers

Gaffo AL, Edwards NL, Saag KG. 2009. Gout. Hyperuricemia and Cardiovascular Disease: How strong is the evidence for a causal link? Arthritis Research and Therapy Journal 11(4): 240. PMID: 19725932

Gaffo AL, Roseman JM, Jacobs DR Jr, Lewis CE, Shikany JM, Mikuls TR, Jolly PE, Saag KG. 2010. Serum urate and its relationship with alcoholic beverage intake in men and women: findings from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. Ann Rheum Dis. 69(11): 1965-70 PMID: 20525839

Gaffo AL, Saag KG. 2010. Febuxostat: the evidence for its use in the treatment of hyperuricemia and gout. Core Evid. 2010 4:25-36. PMID: 20694062

Gaffo AL. 2010. Diagnostic approach to ANCA-associated vasculitides. Rheum Dis Clin North Am. 36(3):491-506. PMID: 20688246

Gaffo AL, Schumacher HR, Saag KG, Taylor WJ, Dinnella J, Outman R, Chen L, Dalbeth N, Sivera F, Vázquez-Mellado J, Chou CT, Zeng X, Perez-Ruiz F, Kowalski SC, Goldenstein-Schainberg C, Chen L, Bardin T, Singh JA. 2012. Developing a provisional definition of flare in patients with established gout. Arthritis Rheum. 64(5):1508-17. PMID:22083456

Gaffo AL, Saag KG. 2012. Drug treatment of hyperuricemia to prevent cardiovascular outcomes: are we there yet? Am J Cardiovasc Drugs. 12(1):1-6. PMID:22204636

Gaffo AL, Jacobs DR Jr, Lewis CE, Mikuls TR, Saag KG. 2012. Association between being African-American, serum urate levels and the risk of developing hyperuricemia: findings from the Coronary Artery Risk Development in Young Adults cohort. Arthritis Res Ther. 14(1):R4. PMID:22225548

Gaffo AL, Jacobs DR Jr, Sijtsma F, Lewis CE, Mikuls TR, Saag KG. 2012. Serum urate association with hypertension in young adults: analysis from the Coronary Artery Risk Development in Young Adults cohort. Ann Rheum Dis. 2012 Sep 14. [Epub ahead of print]PMID:22984170

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O'Seaghdha CM, Haller T, Yang Q, Tanaka T, Johnson AD, Kutalik Z, Smith AV, Shi J, Struchalin M, Middelberg RP, Brown MJ, Gaffo AL, et al,. 2013. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 45(2):145-54. PMID:23263486

Gaffo AL.2013. Thrombosis in vasculitis. Best Pract Res Clin Rheumatol. 27(1):57-67. PMID: 23507057

Wang H, Jacobs DR Jr, Gaffo AL, Gross MD, Goff DC Jr, Carr JJ. 2013. Longitudinal association between serum urate and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults (CARDIA) study. J Intern Med. 274(6):594-609. PMID: 23952533 PMCID: PMC3825786

Sattui SE, Singh JA, Gaffo AL. 2014. Comorbidities in patients with crystal diseases and hyperuricemia. Rheum Dis Clin North Am. 40(2):251-78. PMID: 24703346 PMCID: PMC4159668


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