Raman, Chander, PhD

ChanderRamanProfessor of Medicine


Shelby Building, Room 305
1825 University Boulevard

Telephone:(205) 934-2472
Email: craman@uab.edu



BSc (Zoology), Madras University, India
MSc (Microbiology), Idaho State University
PhD (Microbiology-Immunology), Southern Illinois University
Postdoctoral Studies, Loyola University in Chicago, Stritch School of Medicine, with Dr. Katherine Knight


Research Description

The overall research focus of the laboratory is the elucidation of mechanisms that regulate generation and maintenance of immune tolerance in T and B lymphocytes. Autoimmunity and predisposition to development of leukemias are the often of the outcomes of alterations in generation and/or maintenance of tolerance. The development of inability of T and B lymphocytes to respond to self antigens while maintaining the ability to respond to self antigens is an active process in which the signals initiated by the engagement of the T cell antigen receptor (TCR) or B cell antigen receptor (BCR) are regulated by a complex of other lymphocyte surface molecules. Signaling cascades initiated by these lymphocyte surface molecules range form those that directly alter the quality and quantity of antigen receptor signals to those that promote cell survival or initiate programmed cell death or apoptosis. Our experimental approaches include in vitro structure function studies to define protein-protein interactions to the use of animal models of disease that naturally occur or are genetically created. Currently our focus is on the cell surface receptors CD5, DR6 and the family of receptors that bind to lignads Blys and April. Each of these receptors play a key role in regulating lymphocyte function and homeostasis and alterations in their signaling activities leads to diverse pathologies. The ultimate goal of our studies is to identify key targets for the development of therapeutic strategies for the treatment of leukemias and autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.



Click here for a more complete list of publications. Below are a few selected papers

Naves R, Singh SP, Cashman KS, Rowse AL, Axtell RC, Steinman L, Mountz JD, Steele C, De Sarno P, Raman C. 2013. The Interdependent, Overlapping, and Differential Roles of Type I and II IFNs in the Pathogenesis of Experimental Autoimmune Encephalomyelitis. J Immunol. 191(6):2967-77. PMID:23960239

Harms AS, Cao S, Rowse AL, Thome AD, Li X, Mangieri LR, Cron RQ, Shacka JJ, Raman C, Standaert DG. 2013. MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration. J Neurosci. 33(23):9592-600. PMID:23739956

Roa NS, Ordoñez-Rueda D, Chávez-Rios JR, Raman C, García-Zepeda EA, Lozano F, Soldevila G. 2013. The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes. Biochem Biophys Res Commun. 432(1):52-9. PMID:23376399

Rowse AL, Naves R, Cashman KS, McGuire DJ, Mbana T, Raman C, De Sarno P. 2012. Lithium controls central nervous system autoimmunity through modulation of IFN-γ signaling. PLoS One. 7(12):e52658. PMID:23285134 Free PMC Article

Aleman-Muench GR, Mendoza V, Stenvers K, Garcia-Zepeda EA, Lopez-Casillas F, Raman C, Soldevila G. 2012. Betaglycan (TβRIII) is expressed in the thymus and regulates T cell development by protecting thymocytes from apoptosis. PLoS One. 2012;7(8):e44217. PMID:22952931 Free PMC Article

Sestero CM, McGuire DJ, De Sarno P, Brantley EC, Soldevila G, Axtell RC, Raman C. 2012. CD5-dependent CK2 activation pathway regulates threshold for T cell anergy. J Immunol. 189(6):2918-30. PMID:22904299 Free PMC Article

Axtell RC, Raman C. 2012. Janus-like effects of type I interferon in autoimmune diseases. Immunol Rev. 248(1):23-35. PMID:22725952 Free PMC Article

Qin H, Yeh WI, De Sarno P, Holdbrooks AT, Liu Y, Muldowney MT, Reynolds SL, Yanagisawa LL, Fox TH 3rd, Park K, Harrington LE, Raman C, Benveniste EN. 2012. Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. Proc Natl Acad Sci U S A. 109(13):5004-9. PMID:22411837 Free PMC Article

Axtell RC, Raman C, Steinman L. 2013. Type I interferons: beneficial in Th1 and detrimental in Th17 autoimmunity. Clin Rev Allergy Immunol. 44(2):114-20. PMID:22231516

Gibson AW, Li X, Wu J, Baskin JG, Raman C, Edberg JC, Kimberly RP. 2012. Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G. J Leukoc Biol. 91(1):97-103. PMID:22003208 Free PMC Article

Katiyar SK, Raman C. 2011. Green tea: a new option for the prevention or control of osteoarthritis. Arthritis Res Ther. 13(4):121. PMID:21861859 Free PMC Article

Lutz J, Heideman MR, Roth E, van den Berk P, Müller W, Raman C, Wabl M, Jacobs H, Jäck HM 2011. Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production. Proc Natl Acad Sci U S A.108(26):10644-9. PMID:21670279

Tabbekh M, Franciszkiewicz K, Haouas H, Lécluse Y, Benihoud K, Raman C, Mami-Chouaib F. 2011. Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice. J Immunol. 187(1):102-9. PMID:21622855

Axtell RC, Raman C, Steinman L. 2011. Interferon-β exacerbates Th17-mediated inflammatory disease. Trends Immunol. 2011 Apr 29. [Epub ahead of print] PMID: 21530402

Soldevila G, Raman C, Lozano F. 2011. The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease. Curr Opin Immunol. 2011 Apr 7. [Epub ahead of print] PMID: 21482089

Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C. 2010. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nature Med. 16(4):406-12 PMID: 20348925

Gagnon J, Chen XL, Forand-Boulerice M, Leblanc C, Raman C, Ramanathan S, Ilangumaran S. 2010. Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression. Immunol Cell Biol.  88(4):451-60. PMID: 20065997

Wang JH, Li J, Wu Q, Yang P, Pawar RD, Xie S, Timares L, Raman C, Chaplin DD, Lu L, Mountz JD, Hsu HC. 2010. Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity. J Immunol. 184(1):442-51.PMID: 19949066

Ordoñez-Rueda D, Lozano F, Sarukhan A, Raman C, Garcia-Zepeda EA, Soldevila G. 2010. Increased numbers of thymic and peripheral CD4+ CD25+Foxp3+ cells in the absence of CD5 signaling. Eur. J Immunol. 39(8):2233-47.PMID: 19609976

Dasu T, Qualls JE, Tuna H, Raman C, Cohen DA, Bondada S. CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells. Immunol Lett. 2008 Aug 15;119(1-2):103-13. Epub 2008 Jun 23. PMID: 18573278

De Sarno P, Axtell RC, Raman C, Roth KA, Alessi DR, Jope RS. Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2008 Jul 1;181(1):338-45. PMID: 18566399

Axtell RC, Xu L, Barnum SR, Raman C. CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system. J Immunol. 2006 Dec 15;177(12):8542-9. PMID: 17142752.

Szalai AJ, Hu X, Raman C, Barnum SR. Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis. Eur J Immunol. 2005 Dec;35(12):3487-92. PMID: 16278814.

Bullard DC, Hu X, Schoeb TR, Axtell RC, Raman C, Barnum SR. Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 15;175(10):6327-33. PMID: 16272284.

Axtell RC, Webb MS, Barnum SR, Raman C. Cutting edge: critical role for CD5 in experimental autoimmune encephalomyelitis: inhibition of engagement reverses disease in mice. J Immunol. 2004 Sep 1;173(5):2928-32. PMID: 15322150.

Kevil CG, Hicks MJ, He X, Zhang J, Ballantyne CM, Raman C, Schoeb TR, Bullard DC. Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease. Am J Pathol. 2004 Aug;165(2):609-16. PMID: 15277234

John B, Herrin BR, Raman C, Wang YN, Bobbitt KR, Brody BA, Justement LB. The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. J Immunol. 2003 Apr 1;170(7):3534-43. PMID: 12646615.

Raman C. CD5, an important regulator of lymphocyte selection and immune tolerance. Immunol Res. 2002;26(1-3):255-63.  PMID: 12403363.

Lu X, Axtell RC, Collawn JF, Gibson A, Justement LB, Raman C. AP2 adaptor complex-dependent internalization of CD5: differential regulation in T and B cells. J Immunol. 2002 Jun 1;168(11):5612-20. PMID: 12023358.


SOM Epilogue Menu