Reynolds, Richard J., IV, PhD

RichardReynoldsAssistant Professor



1530 3rd Avenue S
Shelby Building, room 178F
Birmingham, AL 35294-2182

Telephone:(205) 975-9300




Rhodes College, 1996
M.Sc.: Texas State University, 2000
Ph.D.: University Of Maryland, College Park, 2008
Postdoctoral Fellow: University Of Alabama at Birmingham, 2010


Research Interests

In the broadest sense my research seeks to elucidate the number, location, and the distribution of effects of genes, and the forces that govern these distributions, on traits of organisms in populations.  To address these questions, I have used a variety of statistical genetic approaches including traditional variance components models of pedigreed populations, quantitative trait locus (QTL) studies and large panels of single nucleotide polymorphisms genotyped in human beings.  My particular interest is inference of genetic effects on the complex disease, rheumatoid arthritis (RA), and using these genetic signals to predict in independent samples whether individuals have varying severity of disease or respond differently to RA therapies.  As a complex disease, environmental effects such as smoking have large effect on RA, and I also have an interest determining if genetic effects on disease might be context-dependent on the environment.   Furthermore, genetic effects may also be contextual on genotypes at other loci, and I aim to estimate these gene by gene interaction effects.  These analyses sometimes require sophisticated statistical approaches with large computational burden.  Thus, in addition to statistical methods application I also develop methods when circumstances require it.  The ultimate goal of the research is to make use of the rich genetic tools and resources and the kind willingness of people to participate in research in order to improve the understanding and treatment of complex diseases such as RA.



Click here for a more complete list of publications. A few selected papers are below.

Aslibekyan S, Sha J, Redden DT, Moreland LW, O'Dell JR, Curtis JR, Mikuls TR, Reynolds RJ, Danila MI, Bridges SL Jr. 2013. Gene-body mass index interactions are associated with methotrexate toxicity in rheumatoid arthritis. Ann Rheum Dis. 73(4):  PMID:24291656

Danila MI, Reynolds RJ, Tiwari HK, Bridges SL Jr. 2013. Ethnic-specific genetic analyses in rheumatoid arthritis: Incremental gains but valuable contributions to the big picture. Arthritis Rheum. 65(12): 2014-2016] PMID:23918636

Aslibekyan S, Brown EE, Reynolds RJ, Redden DT, Morgan S, Baggott JE, Sha J, Moreland LW, O'Dell JR, Curtis JR, Mikuls TR, Bridges SL Jr, Arnett DK. 2013. Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: results from the treatment of early aggressive rheumatoid arthritis trial. Pharmacogenomics J. 14(1): 48-53. PMID:23545897

Reynolds RJ, Cui X, Vaughan LK, Redden DT, Causey Z, Perkins E, Shah T, Hughes LB; CLEAR Investigators, Damle A, Kern M, Gregersen PK, Johnson MR, Bridges SL Jr. 2013. Gene expression patterns in peripheral blood cells associated with radiographic severity in African Americans with early rheumatoid arthritis. Rheumatol Int. 33(1):129-37. PMID:22238028

Perkins EA, Landis D, Causey ZL, Edberg Y, Reynolds RJ, Hughes LB, Gregersen PK, Kimberly RP, Edberg JC, Bridges SL Jr; Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis Investigators. 2012. Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans. Arthritis Rheum. 64(5):1355-8. PMID:22127930 

Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL Jr. 2010. Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans. Arthritis Rheum. 62(12):3547-53. PMID: 21120996

Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD Jr, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL Jr. 2010. Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans. Arthritis Rheum. 62(12):3547-3553. PMID: 21120996

Mikuls TR, Sayles H, Yu F, Levan T, Gould KA, Thiele GM, Conn DL, Jonas BL, Callahan LF, Smith E, Brasington R, Moreland LW, Reynolds RJ, Bridges SL Jr. 2010. Associations of cigarette smoking with rheumatoid arthritis in African Americans. Arthritis Rheum. 62(12):3560-8.  PMID: 20722010

Li, J, R.J. Reynolds, D. Pomp, D.B. Allison, N. Yi. Mapping Interacting QTL for Count Phenotypes Using Hierarchical Poisson and Binomial Models: an Application to Reproductive Traits in Mice. Genetics Research. 2010. 92(1):13-23. PMID: 20199696

Reynolds, R.J., D. Childers, and N. Pajewski. 2010. The distribution and hypothesis testing of eigenvalues from the canonical analysis of the gamma matrix of quadratic and correlational selection gradients. Evolution. 64(4): 1076-1086. PMCID: PMC2857515

Reynolds, R.J., J. Kelley, L. Hughes, N. Yi, and S.L. Bridges. 2010. Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African American population. Genes and Immunity 11:94-97 PMID: 19741715

Reynolds, R.J., M.R. Dudash, C.B. Fenster. 2009. Multi-year study of multivariate linear and nonlinear phenotypic selection on floral traits of hummingbird-pollinated Silene virginica. Evolution 64:358-369 PMID: 19663992

Reynolds, R.J., M.J. Westbrook, A.S. Rohde, J.M. Cridland, C.B. Fenster, and M.R. Dudash. 2009. Pollinator specialization and pollination syndromes of three related North American Silene. Ecology 90: 2077-2087 PMID: 19739370

Reynolds, R.J. and C.B. Fenster. 2008. Point and interval estimation of pollinator importance: A study using pollination data of Silene caroliniana Oecologia 156: 325-332 PMID: 18283498

Kephart, S., R.J. Reynolds, M.T. Rutter, C.B. Fenster, and M.R. Dudash. 2006. Pollination and seed predation by moths on Silene and allied Caryophyllaceae: Evaluating a model system to study the evolution of mutualisms. New Phytologist 169: 637-651 PMID: 16441748



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