Zheng-Yu Wang, Ph.D.Assistant Professor

Areas of Interest
xenoimmunology, xenotransplantation, xenotransfusion, immunology

Biography

Dr. Wang’s current research focuses on identifying human antibody-mediated target antigens on pig kidney/liver/skin cells using CRISPR/cas 9 gene editing, including carbohydrate xenoantigens, SLA Class I and Class II, developing a novel strategy for inducing human T-cell tolerance to pig xenotransplantation to humans, and understanding the mechanisms by porcine liver sinusoidal cells to phagocytose human platelets, thereby alleviating the lethal thrombocytopenia observed after pig liver xenotransplantion, as well as characterizing RBC from gene-editing pigs for pig-to-primate xenotransfuion. In summary, his experience and expertise in the field of immunology and xenoimmunology have prepared him for xenotransplantation research.

Selected Publications

Wang ZY, Martens GR, Blankenship RL, Sidner RA, Li P, Estrada JL, Tector M, Tector AJ. Eliminating xenoantigen expression on swine RBC. Transplantation 2016 Jul.

Butler JR, Wang ZY, Martens GR, Ladowski JM, Li P, Tector M, Tector AJ. Modified glycan models of pig-to-humman xenotransplantation do not enhance the human-anti-pig T cell response. Transplant Immunology 2016 35:47-51.

Wang ZY, Li P, Butler JR, Blankenship RL, Downey SM, Montgomery JB, Nagai S, Estrada JL, Tector M, Tector AJ. Immunogenicity of renal microvascular endothelial cells from genetically modified pigs. Transplantation 2016,100(3):533-537.

Wang ZY, Burlak C, Estrada JL, Tector M, Tector AJ. Erythrocytes from GGTA1/CMAH knockout pigs: implications for xenotransfusion and testing in non-human primates. Xenotransplantation 2014; 21(4).376-84

Reyes LM, Estrada JL, Wang ZY, Blosser RJ, Smith RF, Sidner RA, Paris LL, Blankenship RL, Miner AC, Tector M, Tector AJ. Creating Class I MHC Null Pigs Using gRNA and the Cas9 Endonuclease. J Immunol. 2014;193(11):5751-7.

Wang ZY, Burlak C, Klaunig JE, Kamendulis JM. Development of Cytokine-Producing Immortalized Murine Kupffer cell line. Cytokine. 2014;70(2):165-72.

Wang ZY, Paris LL, Chihara PK, Tector AJ, Burlak C. (2012). Immortalized porcine liver sinusoidal endothelial Cells: an in vitro model of xenotransplantation-induced thrombocytopenia. Xenotransplantation, 19(4):249-55.

Burlak C, Wang ZY, Chihara RK, Lutz AJ, Wang Y, Estrada JL, Tector AJ. (2012) Identification of human preformed antibody targets in GTKO pigs. Xenotransplantation 19: 92-101

Wang ZY, Kusam S, Munugalavadla V, Kapur R, Brutkiewicz RR, and Dent AL. (2006). Regulation of Th2 Cytokine Expression in NKT Cells: Unconventional Use of Stat6, GATA-3, and NFAT2. J Immunol. (2): 880-8.

Wang ZY, Sato H, Kusam S, Sehra S, Toney LM and Dent AL. (2005). Regulation of IL-10 gene expression in T help type 2 cells by Jun proteins. J Immunol.174(4):2098-105.

Contact

Campus Address
Tinsley Harrison Tower
Room 710

Phone
205-975-7622

Email
zywang@uabmc.edu