Associate Professor
Research Interests
kidney stone disease, primary hyperoxaluria, enteric hyperoxaluria, oxalate, oxalate degrading bacteria
Biography
Since his arrival at UAB in 2012, John Knight’s efforts have primarily focused on performing cross-disciplinary and multi-institutional basic and translational research on kidney stone disease. His current research is investigating endogenous oxalate synthesis and the impact of gut oxalate degrading bacteria on urinary oxalate excretion. His research utilizes carbon-13 stable isotopes and mass spectrometry-based techniques to unravel metabolic pathways in healthy volunteers and patients with a history of kidney stone disease. Within UAB, he is the Director of the Cardio-Renal Journal Club (GBSC 700), a senior leader in the UAB KURE mentoring program, a member of the UAB Faculty Mentoring Facilitator Task Force, a Research Integrity Officer on the UAB HSOM Committee for Responsible Research Practices, and serves on the Urology Promotions and Tenure Committee. Outside the institution, he is Secretary/Treasurer of the R.O.C.K Society, a group of clinical and basic science experts committed to advancing knowledge in the field of kidney stone disease.
Education and Degrees
Graduate
University of Newcastle-upon-Tyne, UK, Ph.D.
Thesis: “Interaction between free radicals and mucus secretions”
Postdoctoral Training
Wake Forest University Health Sciences
Awards/Honors
2013 Early Career Reviewer (ECR) program at the Center for Scientific Review (CSR), National Institute of Health
2013 AUA Best Poster Winner. AUA Annual Meeting, San Diego, CA, USA. “2075: Hydroxyproline Metabolism to Urinary Oxalate and Glycolate Excretion in Normal Subjects.”
2011 OLYMPUS Best Basic Research Paper - MP05-09: Glyoxal Metabolism: A novel pathway in endogenous oxalate synthesis. Endourology Society.
2005 Poster of Distinction. 7th International Workshop on Primary Hyperoxaluria.
1997 Phil Hearne Award, PhD, University of Newcastle-upon-Tyne, UK
1996 Physiology Award, Department of Physiology, University of Newcastle-upon-Tyne, UK
Institutional Activities
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Graduate Biomedical Science Faculty (GBS):
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Cell Molecular & Developmental Biology, Microbiology, Pathobiology & Molecular Medicine
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Appointment in Nephrology and Training Center
Society Memberships
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The American Physiological Society
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Research on Calculus Kidney Kinetics (R.O.C.K) Society
Publications
Contact Information
Location
816 Kaul Genetics Building
Phone
205-996-2295