Associate Professor

Research Interests
kidney stone disease, interstitial cystitis/painful bladder syndrome, immune cells, mitochondria, oxidative stress, inflammation

Website: Mitchell Laboratory

Research Summary

The overall theme of Dr. Mitchell’s research has been to study disorders that affect the kidney and to identify potential ways to improve the health and quality of life of individuals with kidney disease. She has a broad background as well as specific training and expertise in mitochondrial function and oxidative stress. For her dissertation studies, Dr. Mitchell examined the effect of cold storage (ischemia) on mitochondrial function and oxidative stress in renal tubular cells and isolated rat kidneys. She determined that mitochondrial reactive oxygen species play a significant role in cold storage injury and this could be reduced by the mitochondrial targeted antioxidant, mitoquinone. As a postdoctoral fellow, she determined that oxidative stress and disruption in autophagy and mitochondrial quality in a Type 1 diabetes model contributes to pancreatic beta cell injury. In addition, Dr. Mitchell evaluated cellular bioenergetics in immune cells from patients diagnosed with chronic kidney disease to monitor disease progression. Dr. Mitchell’s current research investigates the role of mitochondria and oxidative stress in immune cells from patients with kidney stone disease and interstitial cystitis/painful bladder syndrome. It is Dr. Mitchell’s hope that her research will provide relevant scientific information to help understand, prevent, and/or treat renal diseases and urological disorders.

Education

Graduate
University of Arkansas for Medical Sciences, Little Rock, AR, Ph.D.

Postdoctoral Training
University of Alabama at Birmingham

Awards/Honors

• 2016-2021 K01 Mentored Scientist Development Award

• 2016 and 2013 The American Physiological Society Travel Fellow

• 2015 UAB Faculty Development Grant Program Awardee

• 2011-2013 T32 Trainee—NIDDK and NHLBI

• 2013 First Awardee of the Dale Benos Scholar Award on the UAB “Interdisciplinary Training in Kidney-Related Research” training grant

• 2013 1st Place Oral Presentation―10th Annual UAB Postdoctoral Research Day

• 2012 Society for Free Radical Biology and Medicine Travel Award

• 2010 Society for Free Radical Biology and Medicine Young Investigator Award

Institutional Activities

• UAB Nephrology Research and Training Center Member

• Secondary Appointment, UAB Department of Cell, Developmental, and Integrative Biology

Society Memberships

• The American Physiological Society

• Birmingham Physiology Network

• American Society of Nephrology

Certifications

• UAB Clinical and Translational Science (CTS) Training Program

• UAB Center for Teaching and Learning Effective Teaching Practice

Contact Information

Location
816 Kaul Genetics Building

Email: taneciam@uab.edu