Displaying items by tag: research

Single-nucleus RNA-sequencing in a newborn pig model showed increased cell cycle activity and proliferation in cardiomyocytes, which helped remuscularize the left ventricle after experimental heart attack.
The grant is being used to fund a first-of-its-kind clinical trial that will recruit healthy individuals through a “genome-first” approach and perform deep metabolic phenotyping to understand the underlying mechanisms responsible for the regulation of the human body’s metabolism through natriuretic peptide hormones.
X-ray crystallography revealed the structure of the HIV-1 matrix protein at 2.1 angstroms resolution, advancing understanding of key mechanisms of viral assembly.
The study revealed that, among critically ill patients undergoing tracheal intubation, fluid bolus administration did not significantly decrease the incidence of cardiovascular collapse.
Vacuuming, mopping, walking a pet or playing catch may be enough activity to avoid a stroke, according to a national study published in JAMA Network Online.
Surprisingly, several competing models for this clathrin-mediated endocytosis all appear to function in two cell lines tested.
All of the newly diagnosed glioblastoma multiforme patients enrolled in a Phase 1 clinical trial have exceeded both their median and expected progression-free survivals. Two patients, to date, have exceeded their expected overall survival.
To facilitate gene-level queries of data from more than 10,000 cancer patient transcriptome sequences and proteomics data from 2,000 patients, researchers have developed a user-friendly cancer data analysis web platform called UALCAN.
This grant is being used to fund the first-of-its-kind and largest clinical study in the United States to perform deep physiological phenotyping and will exclusively recruit Black adults to study the use of FDA-approved medications and their role in improving cardiometabolic health.
New findings published in the Journal of the American Medical Association show an eGFR equation that excludes race as a coefficient and includes creatine and cystatin C measurements could demonstrate racial differences in the risk of kidney failure requiring dialysis.
The biodegradable nanovehicles accumulated in human breast cancer tumors in mice after systemic injection, and they inhibited oncogene expression and extended survival of the mice.
The $20 million National Science Foundation award will help UAB and eight other Alabama-based universities build research infrastructure. UAB’s share will be about $2 million.
The drug inhibits the kinase Cdk5, found in mature neurons. Cdk5 has long been implicated in neuropsychiatric and neurodegenerative conditions, but previous inhibitors have largely failed to reach the brain through the blood-brain barrier.
This discovery validates siderophore secretion as a drug target in tuberculosis and reveals a new mechanism for putative drugs. Many tuberculosis bacteria are highly resistant to multiple antibiotics.
This novel mode of altering gene silencing boosts the unfolded protein response pathway in the cancer cells, helping those cells survive during rapid growth.
For just the third time in history, a University of Alabama at Birmingham faculty member has been elected to the prestigious National Academy of Sciences.
UAB women’s health experts found that prophylactic anticoagulation guidelines did not reduce risk of venous thromboembolisms but did increase the risk for bleeding complications in the general obstetric population.
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