Research - News
The drug Vismodegib, tested in a breast cancer model, is an inhibitor of hedgehog signaling, a form of cell communication manipulated by the tumor microenvironment.
Edwin Aroke, Ph.D., will examine factors, including epigenetics, that play a role in chronic lower back pain in order to improve the quality of life for patients.
People respond to weight loss strategies in different ways, but typical studies test only one intervention at a time. UAB’s Drew Sayer is testing multiple strategies in a single study.
UAB researchers found that death due to cardiovascular causes in the Southeastern U.S. is 16 percent higher than in the rest of the country, and an estimated 101,953 additional deaths need to be prevented by 2025 to bridge this gap.

Understanding how reductive stress is controlled may help personalize treatment of heart failure patients, leading to better outcomes.

The histone methyltransferase DOT1L — the potential target — is overexpressed in ovarian cancer, and high levels of expression correlate with reduced progression-free and overall survival.
Six graduate students in the Academic Medical Center of the 21st Century scholarship program will network with medical professionals, train with top research doctors and receive research funding from the UAB School of Medicine. 
UAB is participating in a nationwide study to treat clinically depressed patients with a VNS device — originally created for treatment of seizure disorders.
Uncontrolled hypertension, or high blood pressure, is a major health concern in underserved communities.

MicroCT of infected human lung tissue, along with histology and immunohistochemistry, was used to construct images of TB granulomas, airways and vasculature.

Michele Talley, Ph.D., will address ways to improve mental health access and increase the behavioral health workforce in grant-funded study.
Intranasal vaccination is needle-free and elicits immunity at the site of infection, the respiratory tract.
This research suggests that a path to treat currently untreatable cases of cystic fibrosis is clearly achievable.
Two Collat School of Business marketing professors support the formation of integrative teams of marketing and sales professionals to facilitate cooperation and meaningful communication, and to mitigate workplace conflict.
A small molecule inhibitor has been identified that reduces the growth of uveal melanoma, a rare and deadly cancer of the eye.
Part of the mission of the Civitan International Research Center is to foster the next generation of scientists studying brain development.
Researchers developed a workplace bullying model through qualitative research to help identify critical issues and bring awareness to the seriousness of the issue.
This study is the latest research to investigate the association between cardiovascular disease and diet — which foods have a positive versus negative impact on cardiovascular disease risk.
Seth Hubbard, a UAB undergraduate student studying neuroscience, has received a grant to test the efficacy of carvedilol as a treatment for retinal degeneration, while participating in a summer research fellowship with Fight for Sight.

Investigations by researchers at UAB reveal the existence of a day/night rhythm of heart hormones, and how the disturbance of this rhythm could contribute to a high risk of high blood pressure and poor cardiovascular health in obese individuals.

This novel virulence trait, which increases severity of S. pneumoniae superinfection, involves pneumococcal surface protein A, now identified as an adhesin.

The alliance will focus on boosting participation in clinical research within historically underrepresented patient groups. 

Gregory Friedman, M.D., has received a special grant to test various therapy combinations with a form of the herpes virus to improve anti-tumor immune response in children battling brain cancer.

A comprehensive health-screening program in rural northern KwaZulu-Natal has found a high burden of undiagnosed or poorly controlled non-communicable diseases.

New results suggest the answer is no, implying that the role of tau in the pathogenesis of Lewy body dementias is distinct from Alzheimer’s disease.
A new R01 study aims to address COVID-19 vaccine hesitancy among African American and Black young adults in the Southern United States.

Responsibility for the safety, integrity and scientific validity of the trials fell to 12 experts of the COVID-19 Vaccine Data and Safety Monitoring Board, who now have taken the unusual step of publishing details of their review process.

New findings include a significant increase in risk of death among patients who had recently had chemotherapy.

Patrick Jones, 74, is the first person in the Southeast and the fourth person in the United States to receive the NEXUS aortic arch stent graft, a minimally invasive solution for aortic arch repair.
In his latest book, “Pandemic Bioethics,” philosophy professor Greg Pence, Ph.D., examines allocation of scarce medical resources, immunity passports, vaccines, discrimination and more. It is available as an e-book now and will be in print June 18.
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