research programs

The O'Neal Comprehensive Cancer Center at UAB is internationally recognized as a leader in the field of cancer research. The center's research programs are organized into three main areas: basic science, translational science, and cancer prevention and control.

Program members work collaboratively within and cross programs on a broad-range of cancer-related topics.

Cancer Cell Biology

The goals of the Cancer Cell Biology (CCB) Program are to conduct the highest quality basic science research related to the three thematic focus areas of the program, to identify and characterize novel pathways and targets involved in tumorigenesis and metastasis, and to develop inhibitors that interfere with those pathways and targets.


Cancer Control and Population Sciences

The goals of the Cancer Control and Population Sciences Program are to reduce the burden of cancer through hypothesis-driven observational and interventional research that spans the bench-to-bedside-to-community at large and targets all stages of neoplasia, from primary, secondary and tertiary prevention, through to end-of-life care.


Cancer Chemoprevention

The goal of the Chemoprevention Program is to prevent cancer through pharmacological intervention or nutritional guidance. Development of effective chemopreventive agents requires identification of the points in cancer progression at which medical intervention or nutritional could inhibit, reverse and/or delay development of certain cancers.


Experimental Therapeutics

The goals of the Experimental Therapeutics Program is to develop novel therapeutic strategies that provide cancer patients with an opportunity for cure, enhanced survival time, slowed disease progression and improved quality of life. 


Inflammation, Immunology and Immunotherapeutics

The goal of the Inflammation, Immunology, and Immunotherapeutics Program is to grow and accelerate research in basic immunology and interactions of cancer and the immune system by developing novel approaches for the treatment of leukemia/lymphoma and solid tumors, and by understanding and exploiting the basic biology of the immune system’s responses to cancers.



The mission of the UAB Comprehensive Cancer Center Neuro-Oncology Program is improve treatment options and therapies for adult and pediatric brain cancer patients through multidisciplinary, translational research.