research programs

The O'Neal Comprehensive Cancer Center at UAB is internationally recognized as a leader in the field of cancer research. The center's research programs are organized into three main areas: basic science, translational science, and cancer prevention and control.

Program members work collaboratively within and cross programs on a broad-range of cancer-related topics.

Cancer Biology & Immunology

The goals of the Cancer Biology & Immunology (CBI) Program are to identify the basic mechanisms governing cancer cell biology and the immune response in order to develop novel therapeutic approaches.

  • Details

    Aims

    • Define how metabolism impacts tumor biology and immune cell activity.
    • Determine how the microenvironment regulates tumor behavior and progression.
    • Assess how epigenetics and genomic instability influence tumor and immune cell function.

    Leadership

    Dr. Troy Randall, MD (Professor, Immunology/Rheumatology), 2018.

    Troy Randall, Ph.D. Program Co-Leader

    Sunil Sudarshan headshot

    Sunil Sudarshan, M.D. Program Co-Leader

Cancer Control & Population Sciences

The goals of the Cancer Control & Population Sciences (CCPS) Program are to reduce the burden of cancer through hypothesis-driven observational and interventional research that spans the bench-to-bedside-to-community at large and targets all stages of neoplasia, from primary, secondary and tertiary prevention, through to end-of-life care.

  • Details

    Aims

    • Study the impact of body weight status and factors that influence energy balance on cancer risk and outcomes
    • Identify host and environmental factors that affect cancer risk through epidemiologic, genomic and cancer research and develop approaches for risk reduction, early detection and treatment of cancer
    • Determine factors that influence cancer-related outcomes and develop behavioral interventions to reduce cancer risk and progression, and improve quality of life in cancer survivors

    Leadership

    Elizabeth Brown headshot

    Elizabeth Brown, Ph.D, MPH Program Co-Leader

    Laura Q. Rogers headshot

    Laura Q. Rogers, M.D., MPH Program Co-Leader

Experimental Therapeutics

The goals of the Experimental Therapeutics (ET) Program are to develop novel imaging, cancer prevention and therapeutic strategies that provide cancer patients with an opportunity for cure, enhanced survival time, slowed disease progression and improved quality of life.

  • Details

    Aims

    • Develop and implement translational imaging, cancer prevention and therapeutic clinical trials and research within the O’Neal Comprehensive Cancer Center, involving faculty collaboration across oncology disciplines.
    • Discover and utilize biomarkers that can aid in the prevention, diagnosis, and treatment of cancer, determination of prognosis of different cancers, prediction of therapeutic response and selection of specific patient populations most likely to benefit from various treatments.
    • Develop novel imaging technology that can be integrated into pre-clinical and translational clinical studies to enhance analysis of cancer prevention and therapeutic effects.

    Leadership

    Dr. Suzanne Lapi

    Suzanne E. Lapi, Ph.D. Program Co-Leader

    Narendra Wajapeyee headshot

    Narendra Wajapeyee, Ph.D. Program Co-Leader

    Eddy S. Yang headshot

    Eddy S. Yang, M.D., Ph.D. Program Co-Leader

Neuro-Oncology

The mission of the UAB Comprehensive Cancer Center Neuro-Oncology (NO) Program is improve treatment options and therapies for adult and pediatric brain cancer patients through multidisciplinary, translational research.

  • Details

    Aims

    • Examine the cellular and molecular biology of human neuroglial tumors and their resultant cellular behaviors responsible for morbidity and mortality in patients.
    • Incorporate basic science observations of neuroglial tumor biology into translational research that can directly lead to development of new diagnostic, prognostic or therapeutic clinical protocols for primary, recurrent or metastatic brain tumors.
    • Provide the highest level of clinical care for patients with nervous system cancers and conduct innovative, investigator-initiated clinical trials in neuro-oncology.
    • Serve patients in our region and identify and address differences in the behavior of therapeutic responsiveness of primary neuroglial tumors in African American patients.
    • Educate physicians and scientists interested in brain tumor biology and treatment.

    Leadership

    Dr. Anita Hjelmeland

    Anita Hjelmeland, Ph.D. Program Co-Leader

    Burt Nabors headshot

    Burt Nabors, M.D. Program Co-Leader

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